Search: ((WFRF:(Strachan David P.)) pers:(Uitterlinden Andre G.)) >
Common variants at ...
Common variants at 12q15 and 12q24 are associated with infant head circumference
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Taal, H. Rob (author)
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St Pourcain, Beate (author)
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Thiering, Elisabeth (author)
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show more...
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Das, Shikta (author)
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Mook-Kanamori, Dennis O. (author)
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Warrington, Nicole M. (author)
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Kaakinen, Marika (author)
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Kreiner-Moller, Eskil (author)
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Bradfield, Jonathan P. (author)
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Freathy, Rachel M. (author)
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Geller, Frank (author)
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Guxens, Monica (author)
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Cousminer, Diana L. (author)
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Kerkhof, Marjan (author)
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Timpson, Nicholas J. (author)
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Ikram, M. Arfan (author)
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Beilin, Lawrence J. (author)
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Bonnelykke, Klaus (author)
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Buxton, Jessica L. (author)
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Charoen, Pimphen (author)
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Chawes, Bo Lund Krogsgaard (author)
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Eriksson, Johan (author)
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Evans, David M. (author)
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Hofman, Albert (author)
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Kemp, John P. (author)
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Kim, Cecilia E. (author)
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Klopp, Norman (author)
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Lahti, Jari (author)
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Lye, Stephen J. (author)
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McMahon, George (author)
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Mentch, Frank D. (author)
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Mueller-Nurasyid, Martina (author)
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O'Reilly, Paul F. (author)
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Prokopenko, Inga (author)
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Rivadeneira, Fernando (author)
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Steegers, Eric A. P. (author)
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Sunyer, Jordi (author)
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Tiesler, Carla (author)
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Yaghootkar, Hanieh (author)
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Breteler, Monique M. B. (author)
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Debette, Stephanie (author)
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Fornage, Myriam (author)
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Gudnason, Vilmundur (author)
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Launer, Lenore J. (author)
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van der Lugt, Aad (author)
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Mosley, Thomas H., Jr. (author)
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Seshadri, Sudha (author)
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Smith, Albert V. (author)
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Vernooij, Meike W. (author)
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Blakemore, Alexandra I. F. (author)
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Chiavacci, Rosetta M. (author)
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Feenstra, Bjarke (author)
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Fernandez-Banet, Julio (author)
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Grant, Struan F. A. (author)
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Hartikainen, Anna-Liisa (author)
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van der Heijden, Albert J. (author)
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Iniguez, Carmen (author)
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Lathrop, Mark (author)
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McArdle, Wendy L. (author)
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Molgaard, Anne (author)
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Newnham, John P. (author)
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Palmer, Lyle J. (author)
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Palotie, Aarno (author)
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Pouta, Annneli (author)
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Ring, Susan M. (author)
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Sovio, Ulla (author)
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Standl, Marie (author)
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Uitterlinden, Andre G. (author)
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Wichmann, H-Erich (author)
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Vissing, Nadja Hawwa (author)
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DeCarli, Charles (author)
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van Duijn, Cornelia M. (author)
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McCarthy, Mark I. (author)
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Koppelman, Gerard H. (author)
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Estivill, Xavier (author)
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Hattersley, Andrew T. (author)
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Melbye, Mads (author)
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Bisgaard, Hans (author)
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Pennell, Craig E. (author)
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Widen, Elisabeth (author)
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Hakonarson, Hakon (author)
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Smith, George Davey (author)
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Heinrich, Joachim (author)
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Jarvelin, Marjo-Riitta (author)
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Jaddoe, Vincent W. V. (author)
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Adair, Linda S. (author)
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Ang, Wei (author)
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Atalay, Mustafa (author)
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van Beijsterveldt, Toos (author)
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Bergen, Nienke (author)
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Benke, Kelly (author)
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Berry, Diane (author)
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Coin, Lachlan (author)
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Davis, Oliver S. P. (author)
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Elliott, Paul (author)
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Flexeder, Claudia (author)
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Frayling, Tim (author)
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Gaillard, Romy (author)
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Groen-Blokhuis, Maria (author)
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Goh, Liang-Kee (author)
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Haworth, Claire M. A. (author)
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Hadley, Dexter (author)
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Hedebrand, Johannes (author)
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Hinney, Anke (author)
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Hirschhorn, Joel N. (author)
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Holloway, John W. (author)
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Holst, Claus (author)
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Hottenga, Jouke Jan (author)
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Horikoshi, Momoko (author)
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Huikari, Ville (author)
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Hypponen, Elina (author)
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Kilpelainen, Tuomas O. (author)
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Kirin, Mirna (author)
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Kowgier, Matthew (author)
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Lakka, Hanna-Maaria (author)
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Lange, Leslie A. (author)
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Lawlor, Debbie A. (author)
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Lehtimaki, Terho (author)
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Lewin, Alex (author)
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Lindgren, Cecilia (author)
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Lindi, Virpi (author)
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Maggi, Reedik (author)
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Marsh, Julie (author)
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Middeldorp, Christel (author)
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Millwood, Iona (author)
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- Murray, Jeffrey C. (author)
- Mittuniversitetet,Institutionen för psykologi och socialt arbete
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Nivard, Michel (author)
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Nohr, Ellen Aagaard (author)
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Ntalla, Ioanna (author)
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Oken, Emily (author)
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Panoutsopoulou, Kalliope (author)
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Pararajasingham, Jennifer (author)
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- Rodriguez, Alina (author)
- Mittuniversitetet,Institutionen för samhällsvetenskap (-2013)
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Salem, Rany M. (author)
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Sebert, Sylvain (author)
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Siitonen, Niina (author)
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Strachan, David P. (author)
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Teo, Yik-Ying (author)
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Valcarcel, Beatriz (author)
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White, Scott (author)
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Willemsen, Gonneke (author)
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Zeggini, Eleftheria (author)
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Boomsma, Dorret I. (author)
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Cooper, Cyrus (author)
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Gillman, Matthew (author)
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Hocher, Berthold (author)
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Lakka, Timo A. (author)
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Mohlke, Karen L. (author)
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Dedoussis, George V. (author)
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Ong, Ken K. (author)
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Pearson, Ewan R. (author)
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Price, Thomas S. (author)
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Power, Chris (author)
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Raitakari, Olli T. (author)
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Saw, Seang-Mei (author)
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Scherag, Andre (author)
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Simell, Olli (author)
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Sorensen, Thorkild I. A. (author)
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Wilson, James F. (author)
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Schmidt, Reinhold (author)
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Vrooman, Henri A. (author)
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Sigurdsson, Sigurdur (author)
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Ropele, Stefan (author)
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Coker, Laura H. (author)
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Longstreth, W. T., Jr. (author)
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Niessen, Wiro J. (author)
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DeStefano, Anita L. (author)
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Beiser, Alexa (author)
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Zijdenbos, Alex P. (author)
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Struchalin, Maksim (author)
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Jack, Clifford R., Jr. (author)
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Nalls, Mike A. (author)
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Au, Rhoda (author)
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Gudnason, Haukur (author)
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Harris, Tamara B. (author)
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Meeks, William M. (author)
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van Buchem, Mark A. (author)
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Catellier, Diane (author)
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Windham, B. Gwen (author)
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Wolf, Philip A. (author)
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Schmidt, Helena (author)
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(creator_code:org_t)
- 2012-04-15
- 2012
- English.
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In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 44:5, s. 532-538
- Related links:
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https://pure.mpg.de/...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- To identify genetic variants associated with head circumference in infancy, we performed a meta-analysis of seven genome-wide association studies (GWAS) (N = 10,768 individuals of European ancestry enrolled in pregnancy and/or birth cohorts) and followed up three lead signals in six replication studies (combined N = 19,089). rs7980687 on chromosome 12q24 (P = 8.1 x 10(-9)) and rs1042725 on chromosome 12q15 (P = 2.8 x 10(-10)) were robustly associated with head circumference in infancy. Although these loci have previously been associated with adult height(1), their effects on infant head circumference were largely independent of height (P = 3.8 x 10(-7) for rs7980687 and P = 1.3 x 10(-7) for rs1042725 after adjustment for infant height). A third signal, rs11655470 on chromosome 17q21, showed suggestive evidence of association with head circumference (P = 3.9 x 10(-6)). SNPs correlated to the 17q21 signal have shown genome-wide association with adult intracranial volume(2), Parkinson's disease and other neurodegenerative diseases(3-5), indicating that a common genetic variant in this region might link early brain growth with neurological disease in later life.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Keyword
- article; body height; brain growth; child; chromosome 12q; chromosome 12q15; chromosome 12q24; degenerative disease; disease association; female; gene locus; genetic association; genetic variability; head circumference; human; infant; infant head circumference; male; meta analysis; Parkinson disease; preschool child; priority journal; single nucleotide polymorphism
Publication and Content Type
- ref (subject category)
- art (subject category)
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Taal, H. Rob
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St Pourcain, Bea ...
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Thiering, Elisab ...
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Das, Shikta
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Mook-Kanamori, D ...
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Warrington, Nico ...
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show more...
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Kaakinen, Marika
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Kreiner-Moller, ...
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Bradfield, Jonat ...
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Freathy, Rachel ...
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Geller, Frank
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Guxens, Monica
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Cousminer, Diana ...
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Kerkhof, Marjan
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Timpson, Nichola ...
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Ikram, M. Arfan
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Beilin, Lawrence ...
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Bonnelykke, Klau ...
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Buxton, Jessica ...
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Charoen, Pimphen
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Chawes, Bo Lund ...
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Eriksson, Johan
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Evans, David M.
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Hofman, Albert
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Kemp, John P.
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Kim, Cecilia E.
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Klopp, Norman
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Lahti, Jari
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Lye, Stephen J.
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McMahon, George
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Mentch, Frank D.
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Mueller-Nurasyid ...
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O'Reilly, Paul F ...
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Prokopenko, Inga
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Rivadeneira, Fer ...
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Steegers, Eric A ...
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Sunyer, Jordi
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Tiesler, Carla
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Yaghootkar, Hani ...
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Breteler, Moniqu ...
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Debette, Stephan ...
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Fornage, Myriam
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Gudnason, Vilmun ...
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Launer, Lenore J ...
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van der Lugt, Aa ...
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Mosley, Thomas H ...
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Seshadri, Sudha
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Smith, Albert V.
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Vernooij, Meike ...
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Blakemore, Alexa ...
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Chiavacci, Roset ...
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Feenstra, Bjarke
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Fernandez-Banet, ...
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Grant, Struan F. ...
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Hartikainen, Ann ...
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van der Heijden, ...
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Iniguez, Carmen
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Lathrop, Mark
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McArdle, Wendy L ...
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Molgaard, Anne
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Newnham, John P.
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Palmer, Lyle J.
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Palotie, Aarno
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Pouta, Annneli
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Ring, Susan M.
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Sovio, Ulla
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Standl, Marie
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Uitterlinden, An ...
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Wichmann, H-Eric ...
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Vissing, Nadja H ...
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DeCarli, Charles
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van Duijn, Corne ...
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McCarthy, Mark I ...
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Koppelman, Gerar ...
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Estivill, Xavier
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Hattersley, Andr ...
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Melbye, Mads
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Bisgaard, Hans
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Pennell, Craig E ...
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Widen, Elisabeth
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Hakonarson, Hako ...
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Smith, George Da ...
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Heinrich, Joachi ...
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Jarvelin, Marjo- ...
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Jaddoe, Vincent ...
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Adair, Linda S.
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Ang, Wei
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Atalay, Mustafa
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van Beijsterveld ...
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Bergen, Nienke
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Benke, Kelly
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Berry, Diane
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Coin, Lachlan
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Davis, Oliver S. ...
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Elliott, Paul
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Flexeder, Claudi ...
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Frayling, Tim
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Gaillard, Romy
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Groen-Blokhuis, ...
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Goh, Liang-Kee
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Haworth, Claire ...
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Hadley, Dexter
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Hedebrand, Johan ...
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Hinney, Anke
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Hirschhorn, Joel ...
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Holloway, John W ...
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Holst, Claus
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Hottenga, Jouke ...
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Horikoshi, Momok ...
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Huikari, Ville
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Hypponen, Elina
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Kilpelainen, Tuo ...
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Kirin, Mirna
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Kowgier, Matthew
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Lakka, Hanna-Maa ...
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Lange, Leslie A.
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Lawlor, Debbie A ...
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Lehtimaki, Terho
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Lewin, Alex
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Lindgren, Cecili ...
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Lindi, Virpi
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Maggi, Reedik
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Marsh, Julie
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Middeldorp, Chri ...
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Millwood, Iona
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Murray, Jeffrey ...
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Nivard, Michel
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Nohr, Ellen Aaga ...
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Ntalla, Ioanna
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Oken, Emily
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Panoutsopoulou, ...
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Pararajasingham, ...
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Rodriguez, Alina
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Salem, Rany M.
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Sebert, Sylvain
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Siitonen, Niina
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Strachan, David ...
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Teo, Yik-Ying
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Valcarcel, Beatr ...
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White, Scott
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Willemsen, Gonne ...
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Zeggini, Elefthe ...
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Boomsma, Dorret ...
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Cooper, Cyrus
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Gillman, Matthew
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Hocher, Berthold
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Lakka, Timo A.
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Mohlke, Karen L.
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Dedoussis, Georg ...
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Ong, Ken K.
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Pearson, Ewan R.
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Price, Thomas S.
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Power, Chris
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Raitakari, Olli ...
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Saw, Seang-Mei
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Scherag, Andre
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Simell, Olli
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Sorensen, Thorki ...
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Wilson, James F.
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Schmidt, Reinhol ...
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Vrooman, Henri A ...
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Sigurdsson, Sigu ...
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Ropele, Stefan
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Coker, Laura H.
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Longstreth, W. T ...
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Niessen, Wiro J.
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DeStefano, Anita ...
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Beiser, Alexa
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Zijdenbos, Alex ...
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Struchalin, Maks ...
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Jack, Clifford R ...
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Nalls, Mike A.
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Au, Rhoda
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Gudnason, Haukur
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Harris, Tamara B ...
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Meeks, William M ...
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van Buchem, Mark ...
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Catellier, Diane
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Windham, B. Gwen
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Wolf, Philip A.
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Schmidt, Helena
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
- Articles in the publication
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Nature Genetics
- By the university
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Mid Sweden University