Common variants at 6q22 and 17q21 are associated with intracranial volume

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Ikram, M. Arfan (author)

Common variants at 6q22 and 17q21 are associated with intracranial volume

Article/chapterEnglish2012

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2012-04-15
Springer Science and Business Media LLC,2012
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LIBRIS-ID:oai:DiVA.org:miun-16878
https://urn.kb.se/resolve?urn=urn:nbn:se:miun:diva-16878URI
https://doi.org/10.1038/ng.2245DOI

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Language:English
Summary in:English

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SwePubSwePub

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

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Erratum published in Nature Genetics 2012 Vol 44 no 6 p732.
During aging, intracranial volume remains unchanged and represents maximally attained brain size, while various interacting biological phenomena lead to brain volume loss. Consequently, intracranial volume and brain volume in late life reflect different genetic influences. Our genome-wide association study (GWAS) in 8,175 community-dwelling elderly persons did not reveal any associations at genome-wide significance (P < 5 x 10(-8)) for brain volume. In contrast, intracranial volume was significantly associated with two loci: rs4273712 (P = 3.4 x 10(-11)), a known height-associated locus on chromosome 6q22, and rs9915547 (P = 1.5 x 10(-12)), localized to the inversion on chromosome 17q21. We replicated the associations of these loci with intracranial volume in a separate sample of 1,752 elderly persons (P = 1.1 x 10(-3) for 6q22 and 1.2 x 10(-3) for 17q21). Furthermore, we also found suggestive associations of the 17q21 locus with head circumference in 10,768 children (mean age of 14.5 months). Our data identify two loci associated with head size, with the inversion at 17q21 also likely to be involved in attaining maximal brain size.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Medicinsk genetik hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Medical Genetics hsv//eng
aged; article; brain size; cephalometry; chromosome 17q; chromosome 17q21; chromosome 6q; chromosome 6q22; female; gene locus; genetic association; genetic variability; human; male; priority journal

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Fornage, Myriam (author)
Smith, Albert V. (author)
Seshadri, Sudha (author)
Schmidt, Reinhold (author)
Debette, Stephanie (author)
Vrooman, Henri A. (author)
Sigurdsson, Sigurdur (author)
Ropele, Stefan (author)
Taal, H. Rob (author)
Mook-Kanamori, Dennis O. (author)
Coker, Laura H. (author)
Longstreth, W. T., Jr. (author)
Niessen, Wiro J. (author)
DeStefano, Anita L. (author)
Beiser, Alexa (author)
Zijdenbos, Alex P. (author)
Struchalin, Maksim (author)
Jack, Clifford R., Jr. (author)
Rivadeneira, Fernando (author)
Uitterlinden, Andre G. (author)
Knopman, David S. (author)
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Pennell, Craig E. (author)
Thiering, Elisabeth (author)
Steegers, Eric A. P. (author)
Hakonarson, Hakon (author)
Heinrich, Joachim (author)
Palmer, Lyle J. (author)
Jarvelin, Marjo-Riitta (author)
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Smith, George Davey (author)
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Au, Rhoda (author)
Hofman, Albert (author)
Gudnason, Haukur (author)
van der Lugt, Aad (author)
Harris, Tamara B. (author)
Meeks, William M. (author)
Vernooij, Meike W. (author)
van Buchem, Mark A. (author)
Catellier, Diane (author)
Jaddoe, Vincent W. V. (author)
Gudnason, Vilmundur (author)
Windham, B. Gwen (author)
Wolf, Philip A. (author)
van Duijn, Cornelia M. (author)
Mosley, Thomas H., Jr. (author)
Schmidt, Helena (author)
Launer, Lenore J. (author)
Breteler, Monique M. B. (author)
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Flexeder, Claudia (author)
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Gaillard, Romy (author)
Groen-Blokhuis, Maria (author)
Goh, Liang-Kee (author)
Haworth, Claire M. A. (author)
Hadley, Dexter (author)
Hedebrand, Johannes (author)
Hinney, Anke (author)
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Hottenga, Jouke Jan (author)
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Huikari, Ville (author)
Hypponen, Elina (author)
Kilpelainen, Tuomas O. (author)
Kirin, Mirna (author)
Kowgier, Matthew (author)
Lakka, Hanna-Maaria (author)
Lange, Leslie A. (author)
Lawlor, Debbie A. (author)
Lehtimaki, Terho (author)
Lewin, Alex (author)
Lindgren, Cecilia (author)
Lindi, Virpi (author)
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Marsh, Julie (author)
Middeldorp, Christel (author)
Millwood, Iona (author)
Murray, Jeffrey C. (author)
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Nohr, Ellen Aagaard (author)
Ntalla, Ioanna (author)
Oken, Emily (author)
Panoutsopoulou, Kalliope (author)
Pararajasingham, Jennifer (author)
Rodriguez, AlinaMittuniversitetet,Institutionen för samhällsvetenskap (-2013)(Swepub:miun)alirod (author)
Salem, Rany M. (author)
Sebert, Sylvain (author)
Siitonen, Niina (author)
Strachan, David P. (author)
Teo, Yik-Ying (author)
Valcarcel, Beatriz (author)
Willemsen, Gonneke (author)
Zeggini, Eleftheria (author)
Boomsma, Dorret I. (author)
Cooper, Cyrus (author)
Gillman, Matthew (author)
Hocher, Berthold (author)
Lakka, Timo A. (author)
Mohlke, Karen L. (author)
Dedoussis, George V. (author)
Ong, Ken K. (author)
Pearson, Ewan R. (author)
Price, Thomas S. (author)
Power, Chris (author)
Raitakari, Olli T. (author)
Saw, Seang-Mei (author)
Scherag, Andre (author)
Simell, Olli (author)
Sorensen, Thorkild I. A. (author)
Wilson, James F. (author)
MittuniversitetetInstitutionen för samhällsvetenskap (-2013) (creator_code:org_t)

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In:Nature Genetics: Springer Science and Business Media LLC44:5, s. 539-5441061-40361546-1718

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By the author/editor: Ikram, M. Arfan; Fornage, Myriam; Smith, Albert V.; Seshadri, Sudha; Schmidt, Reinhol ...; Debette, Stephan ...; show more...; Vrooman, Henri A ...; Sigurdsson, Sigu ...; Ropele, Stefan; Taal, H. Rob; Mook-Kanamori, D ...; Coker, Laura H.; Longstreth, W. T ...; Niessen, Wiro J.; DeStefano, Anita ...; Beiser, Alexa; Zijdenbos, Alex ...; Struchalin, Maks ...; Jack, Clifford R ...; Rivadeneira, Fer ...; Uitterlinden, An ...; Knopman, David S ...; Hartikainen, Ann ...; Pennell, Craig E ...; Thiering, Elisab ...; Steegers, Eric A ...; Hakonarson, Hako ...; Heinrich, Joachi ...; Palmer, Lyle J.; Jarvelin, Marjo- ...; McCarthy, Mark I ...; Grant, Struan F. ...; St Pourcain, Bea ...; Timpson, Nichola ...; Smith, George Da ...; Sovio, Ulla; Nalls, Mike A.; Au, Rhoda; Hofman, Albert; Gudnason, Haukur; van der Lugt, Aa ...; Harris, Tamara B ...; Meeks, William M ...; Vernooij, Meike ...; van Buchem, Mark ...; Catellier, Diane; Jaddoe, Vincent ...; Gudnason, Vilmun ...; Windham, B. Gwen; Wolf, Philip A.; van Duijn, Corne ...; Mosley, Thomas H ...; Schmidt, Helena; Launer, Lenore J ...; Breteler, Moniqu ...; DeCarli, Charles; Adair, Linda S.; Ang, Wei; Atalay, Mustafa; vanBeijsterveldt ...; Bergen, Nienke; Benke, Kelly; Berry, Diane; Coin, Lachlan; Davis, Oliver S. ...; Elliott, Paul; Flexeder, Claudi ...; Frayling, Tim; Gaillard, Romy; Groen-Blokhuis, ...; Goh, Liang-Kee; Haworth, Claire ...; Hadley, Dexter; Hedebrand, Johan ...; Hinney, Anke; Hirschhorn, Joel ...; Holloway, John W ...; Holst, Claus; Hottenga, Jouke ...; Horikoshi, Momok ...; Huikari, Ville; Hypponen, Elina; Kilpelainen, Tuo ...; Kirin, Mirna; Kowgier, Matthew; Lakka, Hanna-Maa ...; Lange, Leslie A.; Lawlor, Debbie A ...; Lehtimaki, Terho; Lewin, Alex; Lindgren, Cecili ...; Lindi, Virpi; Maggi, Reedik; Marsh, Julie; Middeldorp, Chri ...; Millwood, Iona; Murray, Jeffrey ...; Nivard, Michel; Nohr, Ellen Aaga ...; Ntalla, Ioanna; Oken, Emily; Panoutsopoulou, ...; Pararajasingham, ...; Rodriguez, Alina; Salem, Rany M.; Sebert, Sylvain; Siitonen, Niina; Strachan, David ...; Teo, Yik-Ying; Valcarcel, Beatr ...; Willemsen, Gonne ...; Zeggini, Elefthe ...; Boomsma, Dorret ...; Cooper, Cyrus; Gillman, Matthew; Hocher, Berthold; Lakka, Timo A.; Mohlke, Karen L.; Dedoussis, Georg ...; Ong, Ken K.; Pearson, Ewan R.; Price, Thomas S.; Power, Chris; Raitakari, Olli ...; Saw, Seang-Mei; Scherag, Andre; Simell, Olli; Sorensen, Thorki ...; Wilson, James F.; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Medical Genetics

Articles in the publication: Nature Genetics

By the university: Mid Sweden University

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