Favourable effects of consuming a Palaeolithic-type diet on characteristics of the metabolic syndrome: a randomized controlled pilot-study

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Boers, ILouis Bolk Inst, Dept Nutr & Hlth, NL-3971 LA Driebergen, Netherlands (författare)

Favourable effects of consuming a Palaeolithic-type diet on characteristics of the metabolic syndrome: a randomized controlled pilot-study

Artikel/kapitelEngelska2014

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2014
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LIBRIS-ID:oai:DiVA.org:miun-23510
https://urn.kb.se/resolve?urn=urn:nbn:se:miun:diva-23510URI
https://doi.org/10.1186/1476-511X-13-160DOI

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Språk:engelska
Sammanfattning på:engelska

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BACKGROUND: The main goal of this randomized controlled single-blinded pilot study was to study whether, independent of weight loss, a Palaeolithic-type diet alters characteristics of the metabolic syndrome. Next we searched for outcome variables that might become favourably influenced by a Paleolithic-type diet and may provide new insights in the pathophysiological mechanisms underlying the metabolic syndrome. In addition, more information on feasibility and designing an innovative dietary research program on the basis of a Palaeolithic-type diet was obtained. METHODS: Thirty-four subjects, with at least two characteristics of the metabolic syndrome, were randomized to a two weeks Palaeolithic-type diet (n = 18) or an isoenergetic healthy reference diet, based on the guidelines of the Dutch Health Council (n = 14). Thirty-two subjects completed the study. Measures were taken to keep bodyweight stable. As primary outcomes oral glucose tolerance and characteristics of the metabolic syndrome (abdominal circumference, blood pressure, glucose, lipids) were measured. Secondary outcomes were intestinal permeability, inflammation and salivary cortisol. Data were collected at baseline and after the intervention. RESULTS: Subjects were 53.5 (SD9.7) year old men (n = 9) and women (n = 25) with mean BMI of 31.8 (SD5.7) kg/m2. The Palaeolithic-type diet resulted in lower systolic blood pressure (-9.1 mmHg; P = 0.015), diastolic blood pressure (-5.2 mmHg; P = 0.038), total cholesterol (-0.52 mmol/l; P = 0.037), triglycerides (-0.89 mmol/l; P = 0.001) and higher HDL-cholesterol (+0.15 mmol/l; P = 0.013), compared to reference. The number of characteristics of the metabolic syndrome decreased with 1.07 (P = 0.010) upon the Palaeolithic-type diet, compared to reference. Despite efforts to keep bodyweight stable, it decreased in the Palaeolithic group compared to reference (-1.32 kg; P = 0.012). However, favourable effects remained after post-hoc adjustments for this unintended weight loss. No changes were observed for intestinal permeability, inflammation and salivary cortisol. CONCLUSIONS: We conclude that consuming a Palaeolithic-type diet for two weeks improved several cardiovascular risk factors compared to a healthy reference diet in subjects with the metabolic syndrome. TRIAL REGISTRATION: Nederlands Trial Register NTR3002.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Hälsovetenskap hsv//swe
MEDICAL AND HEALTH SCIENCES Health Sciences hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Hälsovetenskap Omvårdnad hsv//swe
MEDICAL AND HEALTH SCIENCES Health Sciences Nursing hsv//eng
Palaeolithic diet
Prevention
Metabolic syndrome
Weight loss correction

Biuppslag (personer, institutioner, konferenser, titlar ...)

Muskiet, F.AUniv Med Ctr Groningen, Dept Lab Med, NL-9713 AV Groningen, Netherlands (författare)
Berkelaar, EUniv Gerona, Dept Clin Psycho Neuro Immunol, Girona, Spain (författare)
Schut, EUniv Gerona, Dept Clin Psycho Neuro Immunol, Girona, Spain (författare)
Penders, RUniv Gerona, Dept Clin Psycho Neuro Immunol, Girona, Spain (författare)
Hoenderdos, KScriptum Commun Nutr, IJsselstein, Netherlands (författare)
Wichers, H.JWageningen Univ & Res Ctr, Wageningen, Netherlands (författare)
Jong, Miek C,1968-Mittuniversitetet,Avdelningen för omvårdnad,Louis Bolk Inst, Dept Nutr & Hlth, NL-3971 LA Driebergen, Netherlands,Omvårdnad(Swepub:miun)miejon (författare)
Louis Bolk Inst, Dept Nutr & Hlth, NL-3971 LA Driebergen, NetherlandsUniv Med Ctr Groningen, Dept Lab Med, NL-9713 AV Groningen, Netherlands (creator_code:org_t)

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Ingår i:Lipids in Health and Disease13:1601476-511X

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Av författaren/redakt...: Boers, I; Muskiet, F.A; Berkelaar, E; Schut, E; Penders, R; Hoenderdos, K; visa fler...; Wichers, H.J; Jong, Miek C, 19 ...; visa färre...

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