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Exercise Intensity ...
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Diment, BethanyBangor University, UK,Extremes Research Group
(författare)
Exercise Intensity and Duration Effects on In Vivo Immunity
- Artikel/kapitelEngelska2015
Förlag, utgivningsår, omfång ...
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2015
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Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:miun-29095
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https://urn.kb.se/resolve?urn=urn:nbn:se:miun:diva-29095URI
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https://doi.org/10.1249/MSS.0000000000000562DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Purpose: To examine the effects of intensity and duration of exercise stress on induction of in vivo immunity in humans using experimental contact hypersensitivity (CHS) with the novel antigen diphenylcyclopropenone (DPCP).Methods: Sixty-four healthy males completed either 30 min running at 60% V˙O2peak (30MI), 30 min running at 80% V˙O2peak (30HI), 120 min running at 60% V˙O2peak (120MI), or seated rest (CON). Twenty min later, the subjects received a sensitizing dose of DPCP; and 4 wk later, the strength of immune reactivity was quantified by measuring the cutaneous responses to a low dose-series challenge with DPCP on the upper inner arm. Circulating epinephrine, norepinephrine and cortisol were measured before, after, and 1 h after exercise or CON. Next, to understand better whether the decrease in CHS response on 120MI was due to local inflammatory or T-cell-mediated processes, in a crossover design, 11 healthy males performed 120MI and CON, and cutaneous responses to a dose series of the irritant, croton oil (CO), were assessed on the upper inner arm.Results: Immune induction by DPCP was impaired by 120MI (skinfold thickness -67% vs CON; P < 0.05). However, immune induction was unaffected by 30MI and 30HI despite elevated circulating catecholamines (30HI vs pre: P < 0.01) and greater circulating cortisol post 30HI (vs CON; P < 0.01). There was no effect of 120MI on skin irritant responses to CO.Conclusions: Prolonged moderate-intensity exercise, but not short-lasting high- or short-lasting moderate-intensity exercise, decreases the induction of in vivo immunity. No effect of prolonged moderate-intensity exercise on the skin's response to irritant challenge points toward a suppression of cell-mediated immunity in the observed decrease in CHS. Diphenylcyclopropenone provides an attractive tool to assess the effect of exercise on in vivo immunity.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Fortes, Matthew BBangor University, UK
(författare)
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Edwards, Jason PBangor University, UK
(författare)
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Hanstock, Helen,1989-Bangor University, UK,Extremes Research Group(Swepub:miun)helhan
(författare)
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Ward, Mark DBangor University, UK
(författare)
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Dunstall, Huw MBangor University, UK
(författare)
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Friedmann, Peter SUniversity of Southampton, UK
(författare)
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Walsh, Neil PBangor University, UK
(författare)
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Bangor University, UKExtremes Research Group
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Medicine & Science in Sports & Exercise47:7, s. 1390-13980195-91311530-0315
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