Myosin content of single muscle fibers following short-term disuse and active recovery in young and old healthy men

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Search: onr:"swepub:oai:DiVA.org:miun-29817" > Myosin content of s...

1 of 1
Previous record
Next record
To hitlist

Details
MARC

Hvid, Lars G.University of Southern Denmark (SDU), Denmark (author)

Myosin content of single muscle fibers following short-term disuse and active recovery in young and old healthy men

Article/chapterEnglish2017

Publisher, publication year, extent ...

Elsevier BV,2017
printrdacarrier

Numbers

LIBRIS-ID:oai:DiVA.org:miun-29817
https://urn.kb.se/resolve?urn=urn:nbn:se:miun:diva-29817URI
https://doi.org/10.1016/j.exger.2016.10.009DOI

Supplementary language notes

Language:English
Summary in:English

Part of subdatabase

SwePubSwePub

Classification

Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

Short-term disuse and subsequent recovery affect whole muscle and single myofiber contractile function in young and old. While the loss and recovery of single myofiber specific force (SF) following disuse and rehabilitation has been shown to correlate with alterations in myosin concentrations in young, it is unknown whether similar relationships exist in old. Therefore, the purpose of the present study was to examine the effect of 14 days lower limb disuse followed by 28 days of active recovery on single muscle fiber myosin content in old (68 yrs) and young (24 yrs) recreationally physically active healthy men. Following disuse, myosin content decreased (p < 0.05) in MHC 1 (young − 28%, old − 19%) and 2a fibers (young − 23%, old − 32%). In old, myosin content decreased more (p < 0.05) in MHC 2a vs 1 fibers. Following recovery, myosin content increased (p < 0.05) and returned to pre-disuse levels for both young and old in both fiber types, with MHC 2a fibers demonstrating an overshooting in young (+ 31%, p < 0.05) but not old. Strong correlations were observed between myosin content and single fiber SF in both young and old, with greater slope steepness in MHC 2a vs 1 fibers indicating an enhanced intrinsic contractile capacity of MHC 2a fibers. In conclusion, adaptive changes in myofiber myosin content appear to occur rapidly following brief periods of disuse (2 wks) and after subsequent active recovery (4 wks) in young and old, which contribute to alterations in contractile function at the single muscle fiber level. Changes in myosin content appear to occur independently of age, while influenced by fiber type (MHC isoform) in young but not old.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Hälsovetenskap hsv//swe
MEDICAL AND HEALTH SCIENCES Health Sciences hsv//eng
Aging
Disuse
Myofiber
Myosin content
Retraining

Added entries (persons, corporate bodies, meetings, titles ...)

Brocca, LorenzaUniversity of Pavia, Italy (author)
Ørtenblad, NielsMittuniversitetet,Avdelningen för hälsovetenskap,University of Southern Denmark (SDU), Denmark,Swedish Winter Sports Research Centre(Swepub:miun)nieort (author)
Suetta, CharlotteUniversity of Copenhagen, Denmark (author)
Aagaard, PerUniversity of Southern Denmark (SDU), Denmark (author)
Kjaer, MichaelUniversity of Copenhagen, Denmark (author)
Bottinelli, RobertoUniversity of Pavia, Italy (author)
Pellegrino, Maria AntoniettaUniversity of Pavia, Italy (author)
University of Southern Denmark (SDU), DenmarkUniversity of Pavia, Italy (creator_code:org_t)

Related titles

In:Experimental Gerontology: Elsevier BV87:Part A, s. 100-1070531-55651873-6815

Internet link

Find in a library

Experimental Gerontology (Search for host publication in LIBRIS)

To the university's database

1 of 1
Previous record
Next record
To hitlist

Find more in SwePub

By the author/editor: Hvid, Lars G.; Brocca, Lorenza; Ørtenblad, Niels; Suetta, Charlott ...; Aagaard, Per; Kjaer, Michael; show more...; Bottinelli, Robe ...; Pellegrino, Mari ...; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Health Sciences

Articles in the publication: Experimental Ger ...

By the university: Mid Sweden University

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se