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Maternal co-exposur...
Maternal co-exposure to mercury and perfluoroalkyl acid isomers and their associations with child neurodevelopment in a Canadian birth cohort
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Reardon, Anthony J. F. (författare)
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Hajihosseini, Morteza (författare)
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Dinu, Irina (författare)
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Field, Catherine J. (författare)
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Kinniburgh, David W. (författare)
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MacDonald, Amy M. (författare)
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Dewey, Deborah (författare)
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England-Mason, Gillian (författare)
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- Martin, Jonathan W. (författare)
- Stockholms universitet,Institutionen för miljövetenskap,Science for Life Laboratory (SciLifeLab),University of Alberta, Edmonton, Alberta, Canada
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APrON Study, The APrON (författare)
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(creator_code:org_t)
- 2023
- 2023
- Engelska.
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Ingår i: Environment International. - 0160-4120 .- 1873-6750. ; 178
- Relaterad länk:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: Perfluoroalkyl acids (PFAAs) within the broader class of per- and polyfluoroalkyl substances (PFAS) are present in human serum as isomer mixtures, but epidemiological studies have yet to address isomer-specific associations with child development and behavior. Objectives: To examine associations between prenatal exposure to 25 PFAAs, including perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) isomers, and child neurodevelopment among 490 mother-child pairs in a prospective Canadian birth cohort, the Alberta Pregnancy Outcomes and Nutrition (APrON) study. To consider the influence of a classic neurotoxicant, total mercury (THg), based on its likelihood of co-exposure with PFAAs from common dietary sources. Methods: Maternal blood samples were collected in the second trimester and child neurodevelopment was assessed at 2 years of age using the Bayley Scales of Infant and Toddler Development, 3rd Edition (Bayley-III). Linear or curvilinear multiple regression models were used to examine associations between exposures and neurodevelopment outcomes. Results: Select PFAAs were associated with lower Cognitive composite scores, including perfluoroheptanoate (PFHpA) (& beta; = -0.88, 95% confidence interval (CI): -1.7, -0.06) and perfluorododecanoate (PFDoA) (& beta; = -2.0, 95% CI: -3.9, -0.01). Non-linear relationships revealed associations of total PFOS (& beta; = -4.4, 95% CI: -8.3, -0.43), and linear-PFOS (& beta; = -4.0, 95% CI: -7.5, -0.57) and 1m-PFOS (& beta; = -1.8, 95% CI: -3.3, -0.24) isomers with lower Language composite scores. Although there was no effect modification, including THg interaction terms in PFAA models revealed negative associations between perfluorononanoate (PFNA) and Motor (& beta; = -3.3, 95% CI: -6.2, -0.33) and Social-Emotional (& beta; = -3.0, 95% CI: -5.6, -0.40) composite scores. Discussion: These findings reinforce previous reports of adverse effects of maternal PFAA exposure during pregnancy on child neurodevelopment. The unique hazards posed from isomers of PFOS justify isomer-specific analysis in future studies. To control for possible confounding, mercury co-exposure may be considered in studies of PFAAs.
Ämnesord
- NATURVETENSKAP -- Geovetenskap och miljövetenskap -- Miljövetenskap (hsv//swe)
- NATURAL SCIENCES -- Earth and Related Environmental Sciences -- Environmental Sciences (hsv//eng)
Nyckelord
- Perfluoroalkyl acids
- Per
- and polyfluoroalkyl substances
- Developmental toxicity
- Child neurodevelopment
- APrON
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- ref (ämneskategori)
- art (ämneskategori)
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Reardon, Anthony ...
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Hajihosseini, Mo ...
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Dinu, Irina
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Field, Catherine ...
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Kinniburgh, Davi ...
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MacDonald, Amy M ...
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visa fler...
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Dewey, Deborah
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England-Mason, G ...
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Martin, Jonathan ...
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APrON Study, The ...
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visa färre...
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Stockholms universitet