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Sökning: id:"swepub:oai:DiVA.org:miun-35863" > Decreased bacterial...

  • Surmeneva, MariaNational Research Tomsk Polytechnic University, Tomsk, Russia (författare)

Decreased bacterial colonization of additively manufactured Ti6Al4V metallic scaffolds with immobilized silver and calcium phosphate nanoparticles

  • Artikel/kapitelEngelska2019

Förlag, utgivningsår, omfång ...

  • Elsevier BV,2019
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:miun-35863
  • https://urn.kb.se/resolve?urn=urn:nbn:se:miun:diva-35863URI
  • https://doi.org/10.1016/j.apsusc.2019.03.003DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • The design of an ideal bone graft substitute has been a long-standing effort, and a number of strategies have been developed to improve bone regeneration. Electron beam melting (EBM) is an additive manufacturing method allowing for the production of porous implants with highly defined external dimensions and internal architectures. The increasing surface area of the implant may also increase the abilities of pathogenic microorganisms to adhere to the surfaces and form a biofilm, which may result in serious complications. The aim of this study was to explore the modifications of Ti6Al4V alloy scaffolds to reduce the abilities of bacteria to attach to the EBM-manufactured implant surface. The layers composed of silver (Ag), calcium phosphate (CaP) nanoparticles (NPs) and combinations of both were formed on the EBM-fabricated metallic scaffolds by electrophoretic deposition in order to provide them with antimicrobial properties. The assay of bacterial colonization on the surface was performed with the exposure of scaffold surfaces to Staphylococcus aureus cells for up to 17 h. Principal component analysis (PCA) was used to assess the relationships between different surface features of the studied samples and bacterial adhesion. The results indicate that by modifying the implant surface with appropriate nanostructures that change the hydrophobicity and the surface roughness at the nano scale, physical cues are provided that disrupt bacterial adhesion. Our results clearly show that AgNPs at a concentration of approximately 0.02 mg/сm 2 that were deposited together with CaPNPs covered by positively charge polyethylenimine (PEI) on the surface of EBM-sintered Ti6Al4V scaffolds hindered bacterial growth, as the total number of attached cells (NAC) of S. aureus remained at the same level during the 17 h of exposure, which indicates bacteriostatic activity. 

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Lapanje, AlesJozef Stefan Institute, Ljubljana, Slovenia (författare)
  • Chudinova, EkaterinaNational Research Tomsk Polytechnic University, Tomsk, Russia (författare)
  • Ivanova, AnnaNational Research Tomsk Polytechnic University, Tomsk, Russia (författare)
  • Koptioug, Andrei,1956-Mittuniversitetet,Institutionen för kvalitets- och maskinteknik(Swepub:miun)andkop (författare)
  • Loza, KaterynaUniversity of Duisburg-Essen, Inorganic Chemistry and Center for Nanointegration Duisburg-Essen (CeNIDE), Essen, Germany (författare)
  • Prymak, OlegUniversity of Duisburg-Essen, Inorganic Chemistry and Center for Nanointegration Duisburg-Essen (CeNIDE), Essen, Germany (författare)
  • Epple, MatthiasUniversity of Duisburg-Essen, Inorganic Chemistry and Center for Nanointegration Duisburg-Essen (CeNIDE), Essen, Germany (författare)
  • Ennen-Roth, FrankaUniversity of Duisburg-Essen, Technical Chemistry and Center for Nanointegration Duisburg-Essen (CeNIDE), Essen, Germany (författare)
  • Ulbricht, MathiasUniversity of Duisburg-Essen, Technical Chemistry and Center for Nanointegration Duisburg-Essen (CeNIDE), Essen, Germany (författare)
  • Rijavec, TomazJozef Stefan Institute, Ljubljana, Slovenia (författare)
  • Surmenev, RomanNational Research Tomsk Polytechnic University, Tomsk, Russia (författare)
  • National Research Tomsk Polytechnic University, Tomsk, RussiaJozef Stefan Institute, Ljubljana, Slovenia (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Applied Surface Science: Elsevier BV480, s. 822-8290169-43321873-5584

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