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  • Sarin, Heikki V.National Institute for Health and Welfare, Helsinki, Finland; University of Helsinki, Helsinki, Finland (author)

Resistance Training Induces Antiatherogenic Effects on Metabolomic Pathways

  • Article/chapterEnglish2019

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  • 2019
  • printrdacarrier

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  • LIBRIS-ID:oai:DiVA.org:miun-37011
  • https://urn.kb.se/resolve?urn=urn:nbn:se:miun:diva-37011URI
  • https://doi.org/10.1249/MSS.0000000000002003DOI

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  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Introduction Arising evidence suggests that resistance training has the potential to induce beneficial modulation of biomarker profile. To date, however, only immediate responses to resistance training have been investigated using high-throughput metabolomics whereas the effects of chronic resistance training on biomarker profile have not been studied in detail. Methods A total of 86 recreationally active healthy men without previous systematic resistance training background were allocated into (i) a resistance training (RT) group (n = 68; age, 33 ± 7 yr; body mass index, 28 ± 3 kg·m-2) and (ii) a non-RT group (n = 18; age, 31 ± 4 yr; body mass index, 27 ± 3 kg·m-2). Blood samples were collected at baseline (PRE), after 4 wk (POST-4wk), and after 16 wk of resistance training intervention (POST-16wk), as well as baseline and after the non-RT period (20-24 wk). Nuclear magnetic resonance-metabolome platform was used to determine metabolomic responses to chronic resistance training. Results Overall, the resistance training intervention resulted in favorable alterations (P < 0.05) in body composition with increased levels of lean mass (2.8%), decreased levels of android (9.6%), and total fat mass (7.5%). These changes in body composition were accompanied by antiatherogenic alterations in serum metabolome profile (false discovery rate < 0.05) as reductions in non-high-density lipoprotein cholesterol (e.g., free cholesterol, remnant cholesterol, intermediate-density lipoprotein cholesterols, low-density lipoprotein cholesterols) and related apolipoprotein B, and increments in conjugated linoleic fatty acids levels were observed. Individuals with the poorest baseline status (i.e., body composition, metabolome profile) benefitted the most from the resistance training intervention. Conclusions In conclusion, resistance training improves cardiometabolic risk factors and serum metabolome even in previously healthy young men. Thus, suggesting attenuated risk for future cardiovascular disease. 

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  • Ahtiainen, Juha P.University of Jyväskylä, Jyväskylä, Finland (author)
  • Hulmi, Juha J.University of Jyväskylä, Jyväskylä, Finland; University of Helsinki, Helsinki, Finland (author)
  • Ihalainen, Johanna K.Mittuniversitetet,Institutionen för hälsovetenskap,University of Jyväskylä, Jyväskylä, Finland,Swedish Winter Sports Research Centre(Swepub:miun)johiha (author)
  • Walker, SimonUniversity of Jyväskylä, Jyväskylä, Finland (author)
  • Küüsmaa-Schildt, MariaUniversity of Jyväskylä, Jyväskylä, Finland (author)
  • Perola, MarkusNational Institute for Health and Welfare, Helsinki, Finland; University of Helsinki, Helsinki, Finland (author)
  • Peltonen, HeikkiUniversity of Jyväskylä, Jyväskylä, Finland (author)
  • National Institute for Health and Welfare, Helsinki, Finland; University of Helsinki, Helsinki, FinlandUniversity of Jyväskylä, Jyväskylä, Finland (creator_code:org_t)

Related titles

  • In:Medicine & Science in Sports & Exercise51:9, s. 1866-18750195-91311530-0315

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