Search: WFRF:(Plotnikov E.)
> (2021) >
Functionalization o...
Functionalization of additive-manufactured Ti6Al4V scaffolds with poly(allylamine hydrochloride)/poly(styrene sulfonate) bilayer microcapsule system containing dexamethasone
- Article/chapterEnglish2021
Publisher, publication year, extent ...
-
Elsevier BV,2021
-
printrdacarrier
Numbers
-
LIBRIS-ID:oai:DiVA.org:miun-42818
-
https://urn.kb.se/resolve?urn=urn:nbn:se:miun:diva-42818URI
-
https://doi.org/10.1016/j.matchemphys.2021.125099DOI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
Porous titanium alloy Ti6Al4V scaffolds manufactured via electron beam melting (EBM®) reveal broad prospects for applications in bone tissue engineering. However, local inflammation and even implant failure may occur while placing an implant into the body. Thus, the application of drug carriers to the surface of a metallic implant can provide treatment at the inflammation site. In this study, we propose to use polyelectrolyte (PE) microcapsules formed by layer-by-layer (LbL) synthesis loaded with both porous calcium carbonate (CaCO3) microparticles and the anti-inflammatory drug dexamethasone (DEX) to functionalize implant surfaces and achieve controlled drug release. Scanning electron microscopy indicated that the CaCO3 microparticles coated with PE bilayers loaded with DEX had a spherical shape with a diameter of 2.3 ± 0.2 μm and that the entire scaffold surface was evenly coated with the microcapsules. UV spectroscopy showed that LbL synthesis allows the manufacturing of microcapsules with 40% DEX. According to high performance liquid chromatography (HPLC) analysis, 80% of the drug was released within 24 h from the capsules consisting of three bilayers of polystyrene sulfonate (PSS) and poly(allylamine)hydrochloride (PAH). The prepared scaffolds functionalized with CaCO3 microparticles loaded with DEX and coated with PE bilayers showed hydrophilic surface properties with a water contact angle below 5°. Mouse embryonic fibroblast cells were seeded on Ti6Al4V scaffolds with and without LbL surface modification. The surface modification with LbL PE microcapsules with CaCO3 core affected cell morphology in vitro. The results confirmed that DEX had no toxic effect and did not prevent cell adhesion and spreading, thus no cytotoxic effect was observed, which will be further studied in vivo.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Koptyug, Andrey,1956-Mittuniversitetet,Institutionen för kvalitets- och maskinteknik,SportsTech Research Centre(Swepub:miun)andkop
(author)
-
Mukhortova, Y.
(author)
-
Pryadko, A.
(author)
-
Volkova, A.
(author)
-
Ivanov, A.
(author)
-
Plotnikov, E.
(author)
-
Khan, Y.
(author)
-
Epple, M.
(author)
-
Sokolova, V.
(author)
-
Prymak, O.
(author)
-
Douglas, T.
(author)
-
Surmenev, R.
(author)
-
Surmeneva, M.
(author)
-
MittuniversitetetInstitutionen för kvalitets- och maskinteknik
(creator_code:org_t)
Related titles
-
In:Materials Chemistry and Physics: Elsevier BV2730254-05841879-3312
Internet link
Find in a library
To the university's database
- By the author/editor
-
Chudinova, E.
-
Koptyug, Andrey, ...
-
Mukhortova, Y.
-
Pryadko, A.
-
Volkova, A.
-
Ivanov, A.
-
show more...
-
Plotnikov, E.
-
Khan, Y.
-
Epple, M.
-
Sokolova, V.
-
Prymak, O.
-
Douglas, T.
-
Surmenev, R.
-
Surmeneva, M.
-
show less...
- About the subject
-
- ENGINEERING AND TECHNOLOGY
-
ENGINEERING AND ...
-
and Materials Engine ...
- Articles in the publication
-
Materials Chemis ...
- By the university
-
Mid Sweden University