Sökning: L773:1600 0560 OR L773:0303 6987 >
PD-1 and PD-L1 in n...
PD-1 and PD-L1 in neoplastic cells and the tumor microenvironment of Merkel cell carcinoma
-
Mitteldorf, C. (författare)
-
Berisha, A. (författare)
-
Tronnier, M. (författare)
-
visa fler...
-
- Pfaltz, Monique C. (författare)
- Mittuniversitetet,Institutionen för psykologi och socialt arbete
-
Kempf, W. (författare)
-
visa färre...
-
(creator_code:org_t)
- 2017-06-22
- 2017
- Engelska.
-
Ingår i: Journal of cutaneous pathology. - : Blackwell Publishing Ltd. - 0303-6987 .- 1600-0560. ; 44:9, s. 740-746
- Relaterad länk:
-
https://urn.kb.se/re...
-
visa fler...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Background: Merkel cell carcinoma (MCC) is an aggressive neoplasm, which is often associated with Merkel cell polyomavirus (MCPyV). Programmed death-1 (PD-1) and its ligand PD-L1 are key players of the tumor microenvironment (TME). Methods: Fourteen paraffin-embedded tissue samples of MCC were stratified by their MCPyV detection. Apart from PD-L1 and PD-1, the TME was further characterized for the expression of CD33, FOXP3 and MxA. Results: We observed PD-1 in 2 of 12 tumors. PD-L1 expression by tumor cells was found in 7 of 8 MCPyV(+) samples and was detected particularly in the periphery. The tumor cells were surrounded by a shield of PD-L1/CD33 immune cells. Expression of PD-L1 by the tumor cells was higher in areas with a denser immune infiltrate. CD33(+) cells without direct tumor contact were PD-L1 negative. Only a low number of FOXP3(+) regulatory T-cells was admixed. Tumor cells of MCPyV(â) samples were mostly PD-L1 negative. Conclusions: Our data demonstrate that PD-L1 expression occurs in tumor and immune cells, in areas in which they are close in contact. Interferon seems to play a role in this interaction. We postulate that PD-L1(+)/CD33(+) cells shield the tumor against attacking PD-1(+) immune cells. Therefore, next to anti-PD-1/PD-L1 antibodies, blockade of CD33 seems to be a promising therapeutic approach. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Annan hälsovetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Other Health Sciences (hsv//eng)
Nyckelord
- CD274 protein
- human
- PDCD1 protein
- human
- programmed death 1 ligand 1
- programmed death 1 receptor
- tumor marker
- aged
- female
- human
- immunology
- male
- merkel cell carcinoma
- skin tumor
- tumor associated leukocyte
- tumor microenvironment
- very elderly
- Aged
- Aged
- 80 and over
- B7-H1 Antigen
- Biomarkers
- Tumor
- Carcinoma
- Merkel Cell
- Female
- Humans
- Lymphocytes
- Tumor-Infiltrating
- Male
- Programmed Cell Death 1 Receptor
- Skin Neoplasms
- Tumor Microenvironment
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas