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Expression of progr...
Expression of programmed death-1 (CD279) in primary cutaneous B-cell lymphomas with correlation to lymphoma entities and biological behaviour
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Mitteldorf, C. (författare)
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Bieri, M. (författare)
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Wey, N. (författare)
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Kerl, K. (författare)
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Kamarachev, J. (författare)
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Pfaltz, Monique C. (författare)
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Kutzner, H. (författare)
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Roncador, G. (författare)
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Tomasini, D. (författare)
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Kempf, W. (författare)
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- 2013-12-02
- 2013
- Engelska.
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Ingår i: British Journal of Dermatology. - : Blackwell Publishing Ltd. - 0007-0963 .- 1365-2133. ; 169:6, s. 1212-1218
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background Programmed death-1 (PD-1/CD279) is a cell-surface protein expressed in activated T cells and a subset of T lymphocytes including follicular helper T cells (TFH). The interaction between PD-1 and its ligands plays a role in immune response and evasion of malignancies. In nodal follicular lymphoma, the number of intratumoral PD-1-positive lymphocytes is associated with overall survival. Objectives To investigate 28 cases of primary cutaneous B-cell lymphoma, including the subtypes PCFCL (n = 10), PCMZL (n = 10) and DLBCL-LT (n = 8) for the number and density of PD-1-positive cells. Methods Immunohistochemical staining and a computerized morphometric analysis for evaluation were applied. The results were correlated with the clinical outcome. To distinguish between activated T cells and TFH we performed PD-1/bcl-6 double staining and compared these results with CXCL-13 staining. Double staining for PD-1 and PAX-5 was used to investigate whether tumour cells were positive for PD-1. Results The PD-1-positive cells represented tumour-infiltrating T cells (TILs). Only a minor subset was represented by TFH. Patients with DLBCL-LT had a significantly lower number of PD-1-positive TILs than those with PCMZL (P = 0·012) and PCFCL (P = 0·002) or both (P = 0·001). The difference between PCMZL and PCFCL did not reach significance (P = 0·074). The tumour cells were negative for PD-1. Conclusions A higher number of PD-1-expressing cells was found in indolent PCMZL and PCFCL than in high-malignant DLBCL-LT. The PD-1-positive cells represented not only TFH, but also other activated T cells as a part of the tumour microenvironment. The tumour cells in all investigated types of PCBCL did not show aberrant PD-1 expression. What’s already known about this topic? In nodal follicular lymphoma, the number of intratumoral programmed death (PD)-1-positive lymphocytes is associated with overall survival. No data exist for primary cutaneous B-cell lymphoma (PCBCL). What does this study add? A higher number of PD-1-expressing cells was found in indolent primary cutaneous marginal zone lymphoma and primary cutaneous follicle centre lymphoma, in contrast to the more aggressive diffuse large B-cell lymphoma, leg type. PD-1-positive cells do not represent only follicular helper T cells. The tumour cells in all investigated types of PCBCL did not show aberrant PD-1 expression. © 2013 British Association of Dermatologists.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Nyckelord
- programmed death 1 receptor
- transcription factor PAX5
- CD3 antigen
- programmed death 1 receptor
- adult
- article
- B cell lymphoma
- cancer cell
- CD3+ T lymphocyte
- cell infiltration
- clinical article
- female
- human
- human tissue
- immunohistochemistry
- large cell lymphoma
- male
- polymerase chain reaction
- priority journal
- protein expression
- skin lymphoma
- T lymphocyte
- B cell lymphoma
- follicular lymphoma
- germinal center
- helper cell
- metabolism
- middle aged
- pathology
- skin tumor
- tumor associated leukocyte
- Antigens
- CD3
- Female
- Germinal Center
- Humans
- Immunohistochemistry
- Lymphocytes
- Tumor-Infiltrating
- Lymphoma
- B-Cell
- Lymphoma
- Follicular
- Male
- Middle Aged
- Programmed Cell Death 1 Receptor
- Skin Neoplasms
- T-Lymphocytes
- Helper-Inducer
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Mitteldorf, C.
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Bieri, M.
-
Wey, N.
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Kerl, K.
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Kamarachev, J.
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Pfaltz, Monique ...
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visa fler...
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Kutzner, H.
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Roncador, G.
-
Tomasini, D.
-
Kempf, W.
-
visa färre...
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