Galectin-3 Expression in Primary Cutaneous CD30-Positive Lymphoproliferative Disorders and Transformed Mycosis Fungoides

• Background: In nodal anaplastic large cell lymphoma, strong expression of galectin-3 (Gal-3) has been found, but only very few cases of primary cutaneous lymphoma have so far been examined. Objectives: To investigate 11 primary cutaneous anaplastic large cell lymphomas (PCALCL), 47 lymphomatoid papuloses (LYP) and 14 cases of transformed mycosis fungoides with CD30 expression (MF-T) for Gal-3 expression. Methods: A Gal-3 score was applied using a photo-based morphometric evaluation program. Double staining for CD30 and Gal-3 was performed. Furthermore, we recorded the cellular and extracellular sublocalization of the signal. Results: The Gal-3 expression in CD30+ tumor cells was significantly lower in MF-T in contrast to CD30+ lymphoproliferative disorders (CD30 LPD; p < 0.001), but we found no differences between PCALCL and LYP (p = 0.42). In PCALCL Gal-3 was more often localized in the cytoplasm in contrast to LYP, in which an equal distribution in the cytoplasm and the nucleus was more common (p = 0.9). Conclusions: The lower Gal-3 expression in MF-T in comparison to CD30 LPD might be an additional criterion to differentiate both entities. The different sublocalization of the Gal-3 signal might reflect a different biological function and behavior. © 2015 S. Karger AG, Basel.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Annan hälsovetenskap (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Other Health Sciences (hsv//eng)

Nyckelord

anaplastic lymphoma kinase

CD30 antigen

epithelial membrane antigen

galectin 3

CD30 antigen

galectin 3

galectin-3

human

adult

antigen expression

Article

cell nucleus

cellular distribution

controlled study

cytoplasm

dendritic cell

female

histology

human

human tissue

immunohistochemistry

large cell lymphoma

lymphocytic infiltration

lymphomatoid papulosis

macrophage

male

mycosis fungoides

practice guideline

primary cutaneous anaplastic large cell lymphoma

priority journal

protein expression

protein localization

signal transduction

skin biopsy

skin lymphoma

tumor cell

adolescent

aged

chemistry

child

cutaneous T cell lymphoma

large cell lymphoma

metabolism

middle aged

mycosis fungoides

pathology

skin tumor

very elderly

young adult

Adolescent

Adult

Aged

Aged

80 and over

Antigens

CD30

Cell Nucleus

Child

Cytoplasm

Female

Galectin 3

Humans

Lymphoma

Primary Cutaneous Anaplastic Large Cell

Lymphoma

T-Cell

Cutaneous

Lymphomatoid Papulosis

Male

Middle Aged

Mycosis Fungoides

Skin Neoplasms

Young Adult

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)