Engraftment syndrome following Hematopoietic stem cell transplantation: a systematic approach toward diagnosis and management

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Maqbool, S. (author)

Engraftment syndrome following Hematopoietic stem cell transplantation : a systematic approach toward diagnosis and management

Article/chapterEnglish2023

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2022-12-02
Springer Science and Business Media LLC,2023
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LIBRIS-ID:oai:DiVA.org:miun-46649
https://urn.kb.se/resolve?urn=urn:nbn:se:miun:diva-46649URI
https://doi.org/10.1007/s12032-022-01894-7DOI

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Language:English
Summary in:English

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SwePubSwePub

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Subject category:ref swepub-contenttype
Subject category:for swepub-publicationtype

Notes

Engraftment syndrome (ES) is a non-infectious complication seen both in autologous and allogeneic hematopoietic stem cell transplants and is characterized by the presence of non-infectious fever, diarrhea, skin rash, pulmonary infiltration, pulmonary edema, and deranged renal and liver function tests This review will be delineating the incidence of ES, important differential diagnoses to be considered and management options. The literature search was done through various databases like PubMed, Google scholar, Cochrane library, and EMBASE. The incidence of engraftment syndrome was ranging from 8 to 50% in patients undergoing Autologous stem cell transplantation while the incidence was 10–77% in patients undergoing Allogeneic stem cell transplantation. Fever was the most commonly observed symptom of ES in both Autologous and Allogeneic stem cell transplantation while the second most frequently reported symptom was non-infectious diarrhea in patients undergoing autologous stem cell transplantation and Skin rash in patients with Allogeneic stem cell transplantation. Pro-inflammatory cytokines and immune response dysregulation were highlighted as the mechanism behind ES development. The significant difference between ES and aGVHD was observed based on cytokines, with IL-12, IL-1β, IL-6, TNF-α, and IFN-γ levels in plasma being higher in patients with ES as compared to patients with aGVHD. Intravenous methylprednisolone was used as the treatment of choice in the majority of the studies. Overall the incidence of ES was high in patients undergoing allogeneic hematopoietic stem cells transplantation. The survival in patients developing ES was less compared to those who did not develop ES. Engraftment syndrome is one of the complications following hematopoietic stem cell transplantation that need early identification, differentiation from infectious complications, and aGVHD and timely initiation of corticosteroids therapy.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Hematologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Hematology hsv//eng
Acute Graft-vs-Host disease
Allogeneic stem cell transplantation
Autologous stem cell transplantation
Engraftment syndrome
Hematopoietic stem cells transplantation

Added entries (persons, corporate bodies, meetings, titles ...)

Nadeem, M. (author)
Shahroz, A. (author)
Naimat, K. (author)
Khan, I. (author)
Tahir, H. (author)
Rehman, A. (author)
Anwer, F. (author)
Iftikhar, R. (author)
Lee, Ka YiuMittuniversitetet,Institutionen för hälsovetenskaper (HOV)(Swepub:miun)kyllee (author)
MittuniversitetetInstitutionen för hälsovetenskaper (HOV) (creator_code:org_t)

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In:Medical Oncology: Springer Science and Business Media LLC40:11357-05601559-131X

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By the author/editor: Maqbool, S.; Nadeem, M.; Shahroz, A.; Naimat, K.; Khan, I.; Tahir, H.; show more...; Rehman, A.; Anwer, F.; Iftikhar, R.; Lee, Ka Yiu; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Hematology

Articles in the publication: Medical Oncology

By the university: Mid Sweden University

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