Liver histopathology of Baltic grey seals (Halichoerus grypus) over three decades

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Schmidt, Britta (author)

Liver histopathology of Baltic grey seals (Halichoerus grypus) over three decades

Article/chapterEnglish2020

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Elsevier BV,2020
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LIBRIS-ID:oai:DiVA.org:nrm-4131
https://urn.kb.se/resolve?urn=urn:nbn:se:nrm:diva-4131URI
https://doi.org/10.1016/j.envint.2020.106110DOI

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Language:English
Summary in:English

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

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The liver plays an important role in the metabolism and elimination of endogenic and exogenic lipid-solublecompounds. Multiple studies have shown that polychlorinated biphenyls (PCB) and dichlorodiphenyl trichloroethane(DDT) lead to morphological changes in liver cells. The aim of the present study was therefore toanalyse liver changes over time in Baltic grey seals (Halichoerus grypus) and to correlate these with historical PCBand DDT contaminations. A total of 191 liver samples were collected between 1981 and 2015 in the Gulf ofBothnia and northern Baltic Proper. Six histological features were evaluated, including portal mononuclear cellinfiltration, random mononuclear cell infiltration, lipid granulomas, hepatocellular fat vacuoles, hepatic stellatecells and mild multifocal bile duct hyperplasia accompanied by portal fibrosis. Three of the six lesions showed asignificant correlation with age. Furthermore, a positive correlation between portal mononuclear cell infiltrationand mild multifocal bile duct hyperplasia was found. Additionally, lipid granulomas were significantly correlatedwith hepatic stellate cells. More importantly, hepatic stellate cells and mild multifocal bile duct hyperplasia werecorrelated with adipose tissue (blubber) concentrations of ƩPCB, measured in a subsample (n = 34) of all individuals.No correlation with lesions and ƩDDT concentrations were found. These results show that age is animportant factor for the development of these liver lesions, but PCBs burden may be an influencing factor. This isin agreement with previous studies of marine mammals in the Baltic Sea as well as in the Arctic. We thereforeconclude that not only age of the animals, but also exposure to PCBs should be taken into account when understandingand evaluating the current health status of Baltic grey seals.

Subject headings and genre

LANTBRUKSVETENSKAPER Veterinärmedicin Patobiologi hsv//swe
AGRICULTURAL SCIENCES Veterinary Science Pathobiology hsv//eng
NATURVETENSKAP Biologi hsv//swe
NATURAL SCIENCES Biological Sciences hsv//eng
Man and the environment
Naturmiljö och människan

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Sonne, Christian (author)
Nachtsheim, Dominik (author)
Wohlsein, Peter (author)
Persson, SaraNaturhistoriska riksmuseet,Enheten för miljöforskning och övervakning (author)
Dietz, Rune (author)
Siebert, Ursula (author)
Naturhistoriska riksmuseetEnheten för miljöforskning och övervakning (creator_code:org_t)

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In:Environment International: Elsevier BV0160-41201873-6750

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By the author/editor: Schmidt, Britta; Sonne, Christian; Nachtsheim, Domi ...; Wohlsein, Peter; Persson, Sara; Dietz, Rune; show more...; Siebert, Ursula; show less...

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AGRICULTURAL SCIENCES: AGRICULTURAL SCI ...; and Veterinary Scien ...; and Pathobiology

NATURAL SCIENCES: NATURAL SCIENCES; and Biological Scien ...

Articles in the publication: Environment Inte ...

By the university: Swedish Museum of Natural History

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