Obesity is Associated With Increased Risk of Crohn's disease, but not Ulcerative Colitis: A Pooled Analysis of Five Prospective Cohort Studies

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Obesity is Associated With Increased Risk of Crohn's disease, but not Ulcerative Colitis : A Pooled Analysis of Five Prospective Cohort Studies

Chan, Simon S. M. (författare): Department of Gastroenterology, Norfolk and Norwich University Hospital NHS Trust, Norwich, United Kingdom; Department of Medicine, Bob Champion Research and Education Building, Norwich Medical School, University of East Anglia, Norwich, United Kingdom

Chen, Ye (författare): Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Harvard Medical School, Boston Massachusetts, USA

Casey, Kevin (författare): Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Harvard Medical School, Boston Massachusetts, USA

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Olen, Ola (författare): Karolinska Institutet

Ludvigsson, Jonas F., 1969- (författare): Karolinska Institutet,Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Department of Paediatrics, Örebro University Hospital, Örebro, Sweden

Carbonnel, Franck (författare): Service de Gastroentérologie, Centre hospitalier Universitaire de Bicêtre, Assistance Publique Hôpitaux de Paris, Université Paris Saclay, Le Kremlin Bicêtre, France; INSERM U1018, Villejuif, France

Oldenburg, Bas (författare): Department of Gastroenterology and Hepatology, University Medical Centre Utrecht, Utrecht, The Netherlands

Gunter, Marc J. (författare): Section of Nutrition and Metabolism, International Agency for Research on Cancer - WHO, Lyon, France

Tjønneland, Anne (författare)

Grip, Olof (författare): Department of Gastroenterology, Skåne University Hospital, Malmö, Sweden

Lochhead, Paul (författare): Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Harvard Medical School, Boston Massachusetts, USA; Gastroenterology Unit, Massachusetts General Hospital, Harvard Medical School, Boston Massachusetts, USA

Chan, Andrew T. (författare): Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Harvard Medical School, Boston Massachusetts, USA; Gastroenterology Unit, Massachusetts General Hospital, Harvard Medical School, Boston Massachusetts, USA

Wolk, Alicja (författare): Karolinska Institutet,Uppsala universitet,Medicinsk epidemiologi,Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden

Khalili, Hamed (författare): Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Harvard Medical School, Boston Massachusetts, USA; Gastroenterology Unit, Massachusetts General Hospital, Harvard Medical School, Boston Massachusetts, USA; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA

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Elsevier, 2022
2022
Engelska.
Ingår i: Clinical Gastroenterology and Hepatology. - : Elsevier. - 1542-3565 .- 1542-7714. ; 20:5, s. 1048-1058

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BACKGROUND AND AIMS: It is unclear whether obesity is associated with the development of inflammatory bowel disease despite compelling data from basic science studies. We therefore examined the association between obesity and risk of Crohn's disease (CD) and ulcerative colitis (UC).METHODS: We conducted pooled analyses of 5 prospective cohorts with validated anthropometric measurements for body mass index (BMI) and waist-hip ratio and other lifestyle factors. Diagnoses of CD and UC were confirmed through medical records or ascertained using validated definitions. We used Cox proportional hazards modeling to calculate pooled multivariable-adjusted HRs (aHRs) and 95% confidence intervals (CIs).RESULTS: Among 601,009 participants (age range, 18-98 years) with 10,110,018 person-years of follow-up, we confirmed 563 incident cases of CD and 1047 incident cases of UC. Obesity (baseline BMI >= 30 kg/m(2)) was associated with an increased risk of CD (pooled aHR, 1.34; 95% CI, 1.05-1.71, I-2 = 0%) compared with normal BMI (18.5 to <25 kg/m(2)). Each 5 kg/m(2) increment in baseline BMI was associated with a 16% increase in risk of CD (pooled aHR, 1.16; 95% CI, 1.05-1.22; I-2 = 0%). Similarly, with each 5 kg/m(2) increment in early adulthood BMI (age, 18-20 years), there was a 22% increase in risk of CD (pooled aHR, 1.22; 95% CI, 1.05-1.40; I-2 = 13.6%). An increase in waist-hip ratio was associated with an increased risk of CD that did not reach statistical significance (pooled aHR across quartiles, 1.08; 95% CI, 0.97-1.19; I-2 = 0%). No associations were observed between measures of obesity and risk of UC.CONCLUSIONS: In an adult population, obesity as measured by BMI was associated with an increased risk of older-onset CD but not UC.

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Av författaren/redakt...: Chan, Simon S. M ...; Chen, Ye; Casey, Kevin; Olen, Ola; Ludvigsson, Jona ...; Carbonnel, Franc ...; visa fler...; Oldenburg, Bas; Gunter, Marc J.; Tjønneland, Anne; Grip, Olof; Lochhead, Paul; Chan, Andrew T.; Wolk, Alicja; Khalili, Hamed; visa färre...

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Obesity is Associated With Increased Risk of Crohn's disease, but not Ulcerative Colitis : A Pooled Analysis of Five Prospective Cohort Studies

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