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  • Chan, Simon S. M.Department of Gastroenterology, Norfolk and Norwich University Hospital NHS Trust, Norwich, United Kingdom; Department of Medicine, Bob Champion Research and Education Building, Norwich Medical School, University of East Anglia, Norwich, United Kingdom (författare)

Obesity is Associated With Increased Risk of Crohn's disease, but not Ulcerative Colitis : A Pooled Analysis of Five Prospective Cohort Studies

  • Artikel/kapitelEngelska2022

Förlag, utgivningsår, omfång ...

  • Elsevier,2022
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:oru-100347
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-100347URI
  • https://doi.org/10.1016/j.cgh.2021.06.049DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-460697URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:150156903URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

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  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding agencies:US Crohn's and Colitis FoundationEuropean CommissionEuropean Commission Joint Research CentreInternational Agency for Research on CancerDanish Cancer SocietyLigue Contre le Cancer (France)Institut Gustave Roussy (France)Mutuelle Generale de l'Education Nationale (France)Institut National de la Sante et de la Recherche Medicale (Inserm)Deutsche KrebshilfeDeutsches Krebsforschungszentrum (Germany)Federal Ministry of Education & Research (BMBF)Fondazione AIRC per la ricerca sul cancroConsiglio Nazionale delle Ricerche (CNR)Dutch Ministry of Public Health, Welfare, and Sports (the Netherlands)Netherlands Cancer Registry (the Netherlands)Netherlands GovernmentHealth Research Fund (Spain)Instituto de Salud Carlos IIIJunta de AndaluciaRegional government of Basque Country (Spain)Regional government of Murcia (Spain)Regional government of Navarra (Spain)Catalan Institute of Oncology (Spain)UK Research & Innovation (UKRI)Medical Research Council UK (MRC)European Commission MR/N003284/1 MC-PC_13048 MC-UU_12015/1 MR/M012190/1  Cancer Research UK C8221/A29017United States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA UM1 CA186107 U01 CA176726 
  • BACKGROUND AND AIMS: It is unclear whether obesity is associated with the development of inflammatory bowel disease despite compelling data from basic science studies. We therefore examined the association between obesity and risk of Crohn's disease (CD) and ulcerative colitis (UC).METHODS: We conducted pooled analyses of 5 prospective cohorts with validated anthropometric measurements for body mass index (BMI) and waist-hip ratio and other lifestyle factors. Diagnoses of CD and UC were confirmed through medical records or ascertained using validated definitions. We used Cox proportional hazards modeling to calculate pooled multivariable-adjusted HRs (aHRs) and 95% confidence intervals (CIs).RESULTS: Among 601,009 participants (age range, 18-98 years) with 10,110,018 person-years of follow-up, we confirmed 563 incident cases of CD and 1047 incident cases of UC. Obesity (baseline BMI >= 30 kg/m(2)) was associated with an increased risk of CD (pooled aHR, 1.34; 95% CI, 1.05-1.71, I-2 = 0%) compared with normal BMI (18.5 to <25 kg/m(2)). Each 5 kg/m(2) increment in baseline BMI was associated with a 16% increase in risk of CD (pooled aHR, 1.16; 95% CI, 1.05-1.22; I-2 = 0%). Similarly, with each 5 kg/m(2) increment in early adulthood BMI (age, 18-20 years), there was a 22% increase in risk of CD (pooled aHR, 1.22; 95% CI, 1.05-1.40; I-2 = 13.6%). An increase in waist-hip ratio was associated with an increased risk of CD that did not reach statistical significance (pooled aHR across quartiles, 1.08; 95% CI, 0.97-1.19; I-2 = 0%). No associations were observed between measures of obesity and risk of UC.CONCLUSIONS: In an adult population, obesity as measured by BMI was associated with an increased risk of older-onset CD but not UC.

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Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Chen, YeClinical and Translational Epidemiology Unit, Massachusetts General Hospital, Harvard Medical School, Boston Massachusetts, USA (författare)
  • Casey, KevinClinical and Translational Epidemiology Unit, Massachusetts General Hospital, Harvard Medical School, Boston Massachusetts, USA (författare)
  • Olen, OlaKarolinska Institutet (författare)
  • Ludvigsson, Jonas F.,1969-Karolinska Institutet,Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Department of Paediatrics, Örebro University Hospital, Örebro, Sweden(Swepub:oru)jsln (författare)
  • Carbonnel, FranckService de Gastroentérologie, Centre hospitalier Universitaire de Bicêtre, Assistance Publique Hôpitaux de Paris, Université Paris Saclay, Le Kremlin Bicêtre, France; INSERM U1018, Villejuif, France (författare)
  • Oldenburg, BasDepartment of Gastroenterology and Hepatology, University Medical Centre Utrecht, Utrecht, The Netherlands (författare)
  • Gunter, Marc J.Section of Nutrition and Metabolism, International Agency for Research on Cancer - WHO, Lyon, France (författare)
  • Tjønneland, Anne (författare)
  • Grip, OlofDepartment of Gastroenterology, Skåne University Hospital, Malmö, Sweden (författare)
  • Lochhead, PaulClinical and Translational Epidemiology Unit, Massachusetts General Hospital, Harvard Medical School, Boston Massachusetts, USA; Gastroenterology Unit, Massachusetts General Hospital, Harvard Medical School, Boston Massachusetts, USA (författare)
  • Chan, Andrew T.Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Harvard Medical School, Boston Massachusetts, USA; Gastroenterology Unit, Massachusetts General Hospital, Harvard Medical School, Boston Massachusetts, USA (författare)
  • Wolk, AlicjaKarolinska Institutet,Uppsala universitet,Medicinsk epidemiologi,Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden(Swepub:uu)alwol516 (författare)
  • Khalili, HamedClinical and Translational Epidemiology Unit, Massachusetts General Hospital, Harvard Medical School, Boston Massachusetts, USA; Gastroenterology Unit, Massachusetts General Hospital, Harvard Medical School, Boston Massachusetts, USA; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA (författare)
  • Department of Gastroenterology, Norfolk and Norwich University Hospital NHS Trust, Norwich, United Kingdom; Department of Medicine, Bob Champion Research and Education Building, Norwich Medical School, University of East Anglia, Norwich, United KingdomClinical and Translational Epidemiology Unit, Massachusetts General Hospital, Harvard Medical School, Boston Massachusetts, USA (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Clinical Gastroenterology and Hepatology: Elsevier20:5, s. 1048-10581542-35651542-7714

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