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Paediatric asthma a...
Paediatric asthma and non-allergic comorbidities : A review of current risk and proposed mechanisms
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- Brew, Bronwyn K. (författare)
- Karolinska Institutet
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- Osvald, Emma Caffrey (författare)
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Solna, Sweden; Pediatric Allergy and Pulmonology Unit, Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden,Karolinska Inst, Dept Med Epidemiol & Biostat, Solna, Sweden.;Karolinska Univ Hosp, Astrid Lindgren Childrens Hosp, Pediat Allergy & Pulmonol Unit, Stockholm, Sweden.
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- Gong, Tong (författare)
- Karolinska Institutet
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- Hedman, Anna M. (författare)
- Karolinska Institutet
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- Holmberg, Kirsten, 1952- (författare)
- Uppsala universitet,Socialmedicin/CHAP
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- Larsson, Henrik, 1975- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Solna, Sweden,Karolinska Inst, Dept Med Epidemiol & Biostat, Solna, Sweden.;Örebro Univ, Sch Med Sci, Örebro, Sweden.
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- Ludvigsson, Jonas F., 1969- (författare)
- Karolinska Institutet
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- Mubanga, Mwenya (författare)
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Solna, Sweden
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- Smew, Awad I. (författare)
- Karolinska Institutet
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- Almqvist, Catarina (författare)
- Karolinska Institutet
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- ISSN 0954-7894
- 2022-07-28
- 2022
- Engelska.
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Ingår i: Clinical and Experimental Allergy. - Stockholm : Wiley-Blackwell Publishing Inc.. - 0954-7894 .- 1365-2222. ; 15:9, s. 1035-1047
- Relaterad länk:
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Abstract
Ämnesord
Stäng
- It is increasingly recognized that children with asthma are at a higher risk of other non-allergic concurrent diseases than the non-asthma population. A plethora of recent research has reported on these comorbidities and progress has been made in understanding the mechanisms for comorbidity. The goal of this review was to assess the most recent evidence (2016-2021) on the extent of common comorbidities (obesity, depression and anxiety, neurodevelopmental disorders, sleep disorders and autoimmune diseases) and the latest mechanistic research, highlighting knowledge gaps requiring further investigation. We found that the majority of recent studies from around the world demonstrate that children with asthma are at an increased risk of having at least one of the studied comorbidities. A range of potential mechanisms were identified including common early life risk factors, common genetic factors, causal relationships, asthma medication and embryologic origins. Studies varied in their selection of population, asthma definition and outcome definitions. Next, steps in future studies should include using objective measures of asthma, such as lung function and immunological data, as well as investigating asthma phenotypes and endotypes. Larger complex genetic analyses are needed, including genome-wide association studies, gene expression-functional as well as pathway analyses or Mendelian randomization techniques; and identification of gene-environment interactions, such as epi-genetic studies or twin analyses, including omics and early life exposure data. Importantly, research should have relevance to clinical and public health translation including clinical practice, asthma management guidelines and intervention studies aimed at reducing comorbidities.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Nyckelord
- Anxiety
- asthma
- children
- comorbidity
- depression
- obesity
- sleep
Publikations- och innehållstyp
- ref (ämneskategori)
- for (ämneskategori)
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- Av författaren/redakt...
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Brew, Bronwyn K.
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Osvald, Emma Caf ...
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Gong, Tong
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Hedman, Anna M.
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Holmberg, Kirste ...
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Larsson, Henrik, ...
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Ludvigsson, Jona ...
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Mubanga, Mwenya
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Smew, Awad I.
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Almqvist, Catari ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Pediatrik
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Lungmedicin och ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Psykiatri
- Artiklar i publikationen
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Clinical and Exp ...
- Av lärosätet
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Örebro universitet
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Karolinska Institutet
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Uppsala universitet