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Impact of Multisite...
Impact of Multisite artery disease on Clinical Outcomes After Percutaneous Coronary Intervention : An Analysis from the e-Ultimaster Registry
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- Kobo, Ofer (author)
- Hillel Yaffe Medical Center, Technion - Faculty of Medicine, Israel
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- Saada, Majdi (author)
- Hillel Yaffe Medical Center, Technion - Faculty of Medicine, Israel
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- von Birgelen, Clemens (author)
- Thoraxcentrum Twente, Medisch Spectrum Twente, Enschede, Netherlands
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- Tonino, Pim A. L. (author)
- Department of Cardiology, Catharina Hospital, Eindhoven, Netherlands
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- Íñiguez-Romo, Andres (author)
- Hospital Alvaro Cunqueiro, University Hospital of Vigo, Vigo, Spain
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- Fröbert, Ole, 1964- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Cardiology
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- Halabi, Majdi (author)
- Ziv Hospital, Safed, Israel
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- Oemrawsingh, Rohit M. (author)
- Albert Schweitzer Ziekenhuis, Dordrecht, Netherlands
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- Polad, Jawed (author)
- Jeroen Bosch Ziekenhuis, 's Hertogenbosch, Netherlands
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- IJsselmuiden, Alexander J. J. (author)
- Cardiology Department, Amphia Hospital Breda, Breda, Netherlands
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- Roffi, Marco (author)
- Division of Cardiology, University Hospitals, Geneva, Switzerland
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- Aminian, Adel (author)
- Centre Hospitalier Universitaire de Charleroi, Charleroi, Belgium
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- Mamas, Mamas A. (author)
- Keele Cardiovascular Research Group, Centre for Prognosis Research, Keele University, United Kingdom
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- Roguin, Ariel (author)
- Hillel Yaffe Medical Center, Technion - Faculty of Medicine, Israel
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(creator_code:org_t)
- 2022-07-25
- 2023
- English.
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In: European Heart Journal - Quality of Care and Clinical Outcomes. - : Oxford University Press. - 2058-5225 .- 2058-1742. ; 9:4, s. 417-426
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
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- BACKGROUND: Multisite artery disease is considered a 'malignant' type of atherosclerotic disease associated with an increased cardiovascular risk, but the impact of multisite artery disease on clinical outcomes after percutaneous coronary intervention (PCI) is unknown.METHODS: Patients enrolled in the large, prospective e-Ultimaster study were grouped into 1) those without known prior vascular disease; 2) those with known single-territory vascular disease 3) those with known 2-3 territories (i.e, coronary, cerebrovascular, or peripheral) vascular disease (multisite artery disease). The primary outcome was coronary target lesion failure (TLF) defined as the composite of cardiac death, target vessel-related myocardial infarction, and clinically driven target lesion revascularization at 1-year. Inverse propensity score weighted (IPSW) analysis was performed to address differences in baseline patient and lesion characteristics.RESULTS: Of the 37,198 patients included in the study, 62.3% had no prior known vascular disease, 32.6% had single-territory vascular disease, and 5.1% multisite artery disease. Patients with known vascular disease were older and were more likely to be men and to have more co-morbidities. After IPSW, the TLF rate incrementally increased with the number of diseased vascular beds (3.16%, 4.44% and 6.42% for no, single- and multisite artery disease, p<0.01 for all comparisons). This was also true for all cause death (2.22%, 3.28% and 5.29%, p<0.01 for all comparisons) and cardiac mortality (1.26%, 1.91% and 3.62%, p≤0.01 for all comparisons).CONCLUSIONS: Patients with previously known vascular disease experienced an increased risk for adverse cardiovascular events and mortality post percutaneous coronary intervention. This risk is highest among patients with multisite artery disease.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- Poly-vascular disease
- vascular disease
- percutaneous coronary intervention
- clinical trial
- human
Publication and Content Type
- ref (subject category)
- art (subject category)
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Kobo, Ofer
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Saada, Majdi
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von Birgelen, Cl ...
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Tonino, Pim A. L ...
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Íñiguez-Romo, An ...
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Fröbert, Ole, 19 ...
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Halabi, Majdi
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Oemrawsingh, Roh ...
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Polad, Jawed
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IJsselmuiden, Al ...
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Roffi, Marco
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Aminian, Adel
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Mamas, Mamas A.
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Roguin, Ariel
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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- Articles in the publication
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European Heart J ...
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Örebro University