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Hidden secrets of t...
Hidden secrets of the cancer genome : unlocking the impact of non-coding mutations in gene regulatory elements
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- Iniguez-Munoz, Sandra (författare)
- Inst Invest Sanitaria Illes Balears IdISBa, Canc Epigenet Lab, Canc Cell Biol Grp, Palma De Mallorca, Spain.
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- Llinas-Arias, Pere (författare)
- Inst Invest Sanitaria Illes Balears IdISBa, Canc Epigenet Lab, Canc Cell Biol Grp, Palma De Mallorca, Spain.
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- Ensenyat-Mendez, Miquel (författare)
- Inst Invest Sanitaria Illes Balears IdISBa, Canc Epigenet Lab, Canc Cell Biol Grp, Palma De Mallorca, Spain.
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- Bedoya-Lopez, Andres F. (författare)
- Inst Invest Sanitaria Illes Balears IdISBa, Canc Epigenet Lab, Canc Cell Biol Grp, Palma De Mallorca, Spain.
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- Orozco, Javier I. J. (författare)
- St Johns Canc Inst, Providence St Johns Hlth Ctr, Santa Monica, CA USA.
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- Cortes, Javier (författare)
- Int Breast Canc Ctr IBCC, Quiron Grp, Pangaea Oncol, Barcelona 08017, Spain.;Med Scientia Innovat Res SL MEDSIR, Barcelona 08018, Spain.;Univ Europea Madrid, Fac Biomed & Hlth Sci, Dept Med, Madrid 28670, Spain.
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- Roy, Ananya (författare)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Neuroonkologi och neurodegeneration
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- Forsberg Nilsson, Karin, 1963- (författare)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Neuroonkologi och neurodegeneration,Univ Nottingham, Biodiscovery Inst, Nottingham, England.
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- DiNome, Maggie L. (författare)
- Duke Univ, Sch Med, Dept Surg, Durham, NC 27710 USA.
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- Marzese, Diego M. (författare)
- Inst Invest Sanitaria Illes Balears IdISBa, Canc Epigenet Lab, Canc Cell Biol Grp, Palma De Mallorca, Spain.;Duke Univ, Sch Med, Dept Surg, Durham, NC 27710 USA.
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Inst Invest Sanitaria Illes Balears IdISBa, Canc Epigenet Lab, Canc Cell Biol Grp, Palma De Mallorca, Spain St Johns Canc Inst, Providence St Johns Hlth Ctr, Santa Monica, CA USA. (creator_code:org_t)
- Springer, 2024
- 2024
- Engelska.
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Ingår i: Cellular and Molecular Life Sciences (CMLS). - : Springer. - 1420-682X .- 1420-9071. ; 81
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Discoveries in the field of genomics have revealed that non-coding genomic regions are not merely "junk DNA", but rather comprise critical elements involved in gene expression. These gene regulatory elements (GREs) include enhancers, insulators, silencers, and gene promoters. Notably, new evidence shows how mutations within these regions substantially influence gene expression programs, especially in the context of cancer. Advances in high-throughput sequencing technologies have accelerated the identification of somatic and germline single nucleotide mutations in non-coding genomic regions. This review provides an overview of somatic and germline non-coding single nucleotide alterations affecting transcription factor binding sites in GREs, specifically involved in cancer biology. It also summarizes the technologies available for exploring GREs and the challenges associated with studying and characterizing non-coding single nucleotide mutations. Understanding the role of GRE alterations in cancer is essential for improving diagnostic and prognostic capabilities in the precision medicine era, leading to enhanced patient-centered clinical outcomes.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Nyckelord
- Enhancers
- Promoters
- Insulators
- Silencers
- Single nucleotide polymorphisms
- Single nucleotide variants
Publikations- och innehållstyp
- ref (ämneskategori)
- for (ämneskategori)
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