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  • Engel, S.Chr. Hansen A/S, Human Health, Scientific Affairs, Hoersholm, Denmark (författare)

Safety of Bifidobacterium breve, Bif195, employing a human exercise-induced intestinal permeability model : a randomised, double-blinded, placebo-controlled, parallel group trial

  • Artikel/kapitelEngelska2022

Förlag, utgivningsår, omfång ...

  • Wageningen Academic Publishers,2022
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:oru-100589
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-100589URI
  • https://doi.org/10.3920/BM2021.0173DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding agency:CRO Atlantia Food Clinical Trials (Cork, Ireland)
  • We have previously shown that the probiotic Bifidobacterium breve strain Bif195 alleviates mucosal injury including ulcer formation in the upper intestine induced by non-steroid anti-inflammatory drugs (NSAIDs). Here, we report additional safety use of Bif195 in 126 healthy humans undergoing an exercise-induced intestinal permeability challenge in a double-blinded, placebo-controlled randomised 6-week intervention trial. Intestinal permeability was assessed by urinary lactulose/rhamnose (L/R) ratio. L/R ratio, plasma intestinal fatty acid binding protein (I-FABP) and gastrointestinal symptom rating scale (GSRS) questionnaire were measured resting and after a 1 h treadmill challenge, prior to and at the end of the intervention. To be able to compare the equivalence of resting state at baseline, of this cohort of well-trained subjects, to non-trained subjects, a cohort of 63 healthy and non-trained subjects (<2 h/week of endurance sports) was included. Study subjects (well-trained) were 35.7% women with a mean age and body mass index (in kg/m2) of 35.0 years and 24.8, respectively. There were no differences between the Bif195 and placebo groups in effects on L/R ratio, I-FABP and GSRS questionnaire score. In addition, there were no differences between Bif195 and placebo in number of adverse events and change in cytokines, liver or kidney biomarkers. The exercise model successfully induced intestinal permeability by statistically significantly increasing L/R ratio by ~100% (P<0.0001) and cytokines after the exercise challenge. No significant difference was found between well-trained and non-trained subjects in baseline resting L/R ratio. In conclusion, the reported cytoprotective effects of Bif195 are unlikely to be primarily related to small bowel permeability, and the safety of Bif195 in individuals with increased permeability is supported by the present data. ClinicalTrials.gov: NCT03027583.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Mortensen, B.Chr. Hansen A/S, Human Health, Scientific Affairs, Hoersholm, Denmark (författare)
  • Wellejus, A.Chr. Hansen A/S, Human Health, Scientific Affairs, Hoersholm, Denmark (författare)
  • Vera-Jimenez, N.Chr. Hansen A/S, Human Health, Scientific Affairs, Hoersholm, Denmark (författare)
  • Struve, C.Chr. Hansen A/S, Human Health, Scientific Affairs, Hoersholm, Denmark (författare)
  • Brummer, Robert Jan,1957-Örebro universitet,Institutionen för medicinska vetenskaper,Nutrition-Gut-Brain Interactions Research Centre(Swepub:oru)rnbr (författare)
  • Damholt, A.Chr. Hansen A/S, Human Health, Scientific Affairs, Hoersholm, Denmark (författare)
  • Woods, T.Mardyke Arena, Cork, Ireland (författare)
  • Shanahan, F.Department of Medicine, University College Cork, Clinical Sciences Building, Cork University Hospital, Wilton, Cork, Ireland; APC Microbiome, Biosciences Building, University College Cork, Ireland (författare)
  • Chr. Hansen A/S, Human Health, Scientific Affairs, Hoersholm, DenmarkInstitutionen för medicinska vetenskaper (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Beneficial Microbes: Wageningen Academic Publishers13:3, s. 243-2521876-28831876-2891

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