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  • Moraes Holst, LuizaGothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology (author)

Downregulated Mucosal Autophagy, Alpha Kinase-1 and IL-17 Signaling Pathways in Active and Quiescent Ulcerative Colitis

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • DOVE MEDICAL PRESS LTD,2022
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:oru-100605
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-100605URI
  • https://doi.org/10.2147/CEG.S368040DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:235928254URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-482133URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-187598URI
  • https://gup.ub.gu.se/publication/318026URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding Agencies:Julins FoundationBengt Ihre FellowshipMagtarmfonden
  • Funding Agencies|Swedish Foundation For Strategic Research; Julins Foundation; Bengt Ihre Fellowship; Wilhelm and Martina Lundgren foundation; Magtarmfonden; Svenska Laekarsaellskapet; Calder foundation; Samhaellet i Goeteborg (KVVS) foundation; Sahlgrenska Academy University of Gothenburg [RB13-016]; Medical Faculty at Uppsala University; Apotekare Hedberg foundation; Swedish Research Council [2021-3743]; Swedish state; Swedish government; ALF-agreement; Regional Executive Board, Region Vaestra Goetaland; [2018-02566]; [2019-01052]; [ALFGBG-932651]; [ALFGBG-722331]; [ALFGBG-723921]; [VGFOUREG-940815]
  • Background: Improved mucosal immune profiling in active and quiescent colonic inflammatory bowel disease (IBD) is needed to develop therapeutic options for treating and preventing flares. This study therefore aimed to provide a comprehensive mucosal characterization with emphasis on immunological host response of patients with active ulcerative colitis (UC active), UC during remission (UC remission) and active colonic Crohn's disease (CD active).Methods: Colonic biopsies from 47 study subjects were collected for gene expression and pathway analyses using the NanoString host-response panel, including 776 genes and 56 immune-related pathways.Results: The majority of mucosal gene expression and signaling pathway scores were increased in active IBD (n=27) compared to healthy subjects (n=10). However, both active IBD and UC remission (n=10) demonstrated decreased gene expression and signaling pathway scores related to autophagy, alpha kinase-1 and IL-17 signaling pathways compared to healthy subjects. Further, UC remission was characterized by decreased scores of several signaling pathways linked to homeostasis along with increased mononuclear cell migration pathway score as compared to healthy subjects. No major differences in the colonic mucosal gene expression between CD active (n=7) and UC (n=20) active were observed.Conclusion: This study indicates that autophagy, alpha kinase-1 and IL-17 signaling pathways are persistently downregulated in UC irrespective of disease activity. Further, UC patients in remission present a unique mucosal environment, potentially preventing patients from reaching and sustaining true homeostasis. These findings may enable better comprehension of the remitting and relapsing pattern of colonic IBD and guide future treatment and prevention of flares.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Halfvarson, Jonas,1970-Örebro universitet,Institutionen för medicinska vetenskaper,Department of Gastroenterology,Örebro Univ, Fac Med & Hlth, Dept Gastroenterol, Örebro, Sweden.(Swepub:oru)jshn (author)
  • Carlson, Marie,1957-Uppsala universitet,Institutionen för medicinska vetenskaper,Uppsala Univ, Sweden(Swepub:uu)maricarl (author)
  • Hedin, CharlotteKarolinska Institutet,Karolinska Inst, Dept Med Solna, Stockholm, Sweden. (author)
  • Kruse, Robert,1972-Örebro universitet,Institutionen för medicinska vetenskaper,Department of Clinical Research Laboratory,Örebro Univ, Fac Med & Hlth, Dept Clin Res Lab, Örebro, Sweden.(Swepub:oru)rke (author)
  • Lindqvist, Carl Mårten,1979-Örebro universitet,Institutionen för medicinska vetenskaper,Örebro Univ, Fac Med & Hlth, Sch Med Sci, Örebro, Sweden.(Swepub:oru)melt (author)
  • Bergemalm, Daniel,1977-Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Gastroenterology,Örebro Univ, Fac Med & Hlth, Dept Gastroenterol, Örebro, Sweden.(Swepub:oru)dbm (author)
  • Almér, SvenKarolinska Institutet,Karolinska Inst, Dept Med Solna, Stockholm, Sweden. (author)
  • Bresso, FrancescaKarolinska Institutet,Karolinska Univ Hosp, Dept Gastroenterol Dermatovenereol & Rheumatol, Gastroenterol Unit, Stockholm, Sweden. (author)
  • Ling Lundström, MariaDepartment of Medical Sciences, Uppsala University, Uppsala, Sweden,Uppsala Univ, Sweden (author)
  • Repsilber, Dirk,1971-Örebro universitet,Institutionen för medicinska vetenskaper,Örebro Univ, Fac Med & Hlth, Sch Med Sci, Örebro, Sweden.(Swepub:oru)drr (author)
  • D'Amato, MauroClinical Epidemiology Division, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; IKERBASQUE, Basque Foundation for Science, Bilbao, Spain; Gastrointestinal Genetics Lab, CIC bioGUNE - BRTA, Derio, Spain,Karolinska Inst, Dept Med Solna, Clin Epidemiol Div, Stockholm, Sweden.;Basque Fdn Sci, IKERBASQUE, Bilbao, Spain.;CIC bioGUNE BRTA, Gastrointestinal Genet Lab, Derio, Spain. (author)
  • Keita, ÅsaLinköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten(Swepub:liu)asave24 (author)
  • Hjortswang, HenrikLinköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Mag- tarmmedicinska kliniken(Swepub:liu)henhj44 (author)
  • Söderholm, Johan DLinköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Kirurgiska kliniken US(Swepub:liu)sodda63 (author)
  • Sundin, JohannaUppsala universitet,Institutionen för medicinska vetenskaper,Sahlgrens Acad, Inst Med, Dept Internal Med & Clin Nutr, Gothenburg, Sweden.,Uppsala Univ, Sweden; Sahlgrens Acad, Sweden (author)
  • Törnblom, Hans,1966Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xtornh (author)
  • Simrén, Magnus,1966Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xsimrm (author)
  • Strid, HansDepartment of Internal Medicine, Södra Älvsborg Hospital, Borås, Sweden,Örebro Univ, Fac Med & Hlth, Sch Med Sci, Örebro, Sweden.;Sodra Alvsborg Hosp, Dept Internal Med, Borås, Sweden. (author)
  • Magnusson, Maria K,1972Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology(Swepub:gu)xmmara (author)
  • Öhman, Lena,1967Gothenburg University,Göteborgs universitet,Uppsala universitet,Institutionen för medicinska vetenskaper,Univ Gothenburg, Inst Biomed, Sahlgrenska Acad, Dept Microbiol & Immunol, Gothenburg, Sweden.;Karolinska Inst, Dept Med Solna, Stockholm, Sweden.;Örebro Univ, Fac Med & Hlth, Sch Med Sci, Örebro, Sweden.;Karolinska Univ Hosp, Dept Gastroenterol Dermatovenereol & Rheumatol, Gastroenterol Unit, Stockholm, Sweden.,Univ Gothenburg, Sweden; Uppsala Univ, Sweden; Karolinska Inst, Sweden; Orebro Univ, Sweden; Karolinska Univ Hosp, Sweden,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology(Swepub:gu)xohmal (author)
  • Ling, Maria K.Uppsala universitet,Institutionen för medicinska vetenskaper(Swepub:uu)malin622 (author)
  • Göteborgs universitetInstitutionen för biomedicin, avdelningen för mikrobiologi och immunologi (creator_code:org_t)

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  • In:Clinical and Experimental Gastroenterology: DOVE MEDICAL PRESS LTD15, s. 129-1441178-7023

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