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Mapping the genetic...
Mapping the genetic and environmental aetiology of autistic traits in Sweden and the United Kingdom
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- Reed, Zoe E. (författare)
- MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK; Department of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK
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- Larsson, Henrik, 1975- (författare)
- Karolinska Institutet,Örebro universitet,Institutionen för medicinska vetenskaper,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Solna, Sweden
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- Haworth, Claire M. A. (författare)
- National Institute for Health Research Biomedical Research Centre, University Hospitals Bristol NHS Foundation Trust, Bristol, UK; The University of Bristol, Bristol, UK; School of Psychological Science, University of Bristol, Bristol, UK; The Alan Turing Institute, London, UK
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- Rai, Dheeraj (författare)
- Department of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol UK; National Institute for Health Research Biomedical Research Centre, University Hospitals Bristol, NHS Foundation Trust, Bristol, UK; The University of Bristol, Bristol, UK; Avon and Wiltshire Partnership, NHS Mental Health Trust, Bath, UK
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- Lundström, Sebastian (författare)
- Gillberg Neuropsychiatry Centre, Centre for Ethics, Law and Mental Health, University of Gothenburg, Gothenburg, Sweden
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- Ronald, Angelica (författare)
- Department of Psychological Sciences, Birkbeck, University of London, London, UK
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- Reichenberg, Abraham (författare)
- Department of Psychiatry and Seaver Autism Center for Research and Treatment, Ichan School of Medicine at Mount Sinai, New York City, New York, USA
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- Lichtenstein, Paul (författare)
- Karolinska Institutet
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- Davis, Oliver S. P. (författare)
- MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK; Department of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK; National Institute for Health Research Biomedical Research Centre, University Hospitals Bristol NHS Foundation Trust, Bristol, UK; School of Psychological Science, University of Bristol, Bristol, UK; The Alan Turing Institute, London, UK
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(creator_code:org_t)
- 2021-10-13
- 2021
- Engelska.
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Ingår i: JCPP Advances. - : John Wiley & Sons. - 2692-9384. ; 1:3
- Relaterad länk:
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https://doi.org/10.1...
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https://onlinelibrar...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background: Autistic traits are influenced by both genetic and environmental factors, and are known to vary geographically in prevalence. But to what extent does their aetiology also vary from place to place?Methods: We applied a novel spatial approach to data on autistic traits from two large twin studies, the Child and Adolescent Twin Study in Sweden (CATSS; N = 16,677, including 8307 twin pairs) and the Twins Early Development Study in the UK (TEDS; N = 11,594, including 5796 twin pairs), to explore how the influence of nature and nurture on autistic traits varies from place to place.Results: We present maps of gene- and environment- by geography interactions in Sweden and the United Kingdom (UK), showing geographical variation in both genetic and environmental influences across the two countries. In Sweden genetic influences appear higher in the far south and in a band running across the centre of the country. Environmental influences appear greatest in the south and north, with reduced environmental influence across the central band. In the UK genetic influences appear greater in the south, particularly in more central southern areas and the southeast, the Midlands and the north of England. Environmental influences appear greatest in the south and east of the UK, with less influence in the north and the west.Conclusions: We hope this systematic approach to identifying aetiological interactions will inspire research to examine a wider range of previously unknown environmental influences on the aetiology of autistic traits. By doing so, we will gain greater understanding of how these environments draw out or mask genetic predisposition and interact with other environmental influences in the development of autistic traits.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Nyckelord
- CATSS
- TEDS
- autism
- environment
- genetics
- geographical variation
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Reed, Zoe E.
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Larsson, Henrik, ...
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Haworth, Claire ...
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Rai, Dheeraj
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Lundström, Sebas ...
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Ronald, Angelica
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Reichenberg, Abr ...
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Lichtenstein, Pa ...
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Davis, Oliver S. ...
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Örebro universitet
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Karolinska Institutet