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  • Pottel, HansDepartment of Public Health and Primary Care , KU Leuven Campus Kulak Kortrijk, Kortrijk , Belgium,Catholic University of Leuven (author)

Standardization of serum creatinine is essential for accurate use of unbiased estimated GFR equations : evidence from three cohorts matched on renal function

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • 2022-08-03
  • Oxford University Press,2022
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:oru-101119
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-101119URI
  • https://doi.org/10.1093/ckj/sfac182DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-488424URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:150535369URI
  • https://lup.lub.lu.se/record/e8b6c094-4d59-4967-8702-2644ebb7a5deURI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding agency:United States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK)
  • Background: Differences in the performance of estimated glomerular filtration rate (eGFR) equations have been attributed to the mathematical form of the equations and to differences between patient demographics and measurement methods. We evaluated differences in serum creatinine (SCr) and eGFR in cohorts matched for age, sex, body mass index (BMI) and measured GFR (mGFR).Methods: White North Americans from Minnesota (n = 1093) and the Chronic Renal Insufficiency Cohort (CRIC) (n = 1548) and White subjects from the European Kidney Function Consortium (EKFC) cohort (n = 7727) were matched for demographic patient characteristics (sex, age +/- 3 years, BMI +/- 2.5 kg/m(2)) and renal function (mGFR +/- 3 ml/min/1.73 m(2)). SCr was measured with isotope dilution mass spectrometry (IDMS)-traceable assays in the Minnesota and EKFC cohorts and with non-standardized SCr assays recalculated to IDMS in the CRIC. The Minnesota cohort and CRIC shared a common method to measure GFR (renal clearance of iothalamate), while the EKFC cohort used a variety of exogenous markers and methods, all with recognized sufficient accuracy. We compared the SCr levels and eGFR predictions [for Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) and EKFC equations] of patients fulfilling these matching criteria.Results: For 305 matched individuals, mean SCr (mg/dL) was not different between the Minnesota and EKFC cohorts (females 0.83 +/- 0.20 versus 0.86 +/- 0.23, males 1.06 +/- 0.23 versus 1.12 +/- 0.37; P > .05) but significantly different from the CRIC [females 1.13 +/- 0.23 (P < .0001), males 1.42 +/- 0.31 (P < .0001)]. The CKD-EPI equations performed better than the EKFC equation in the CRIC, while the opposite was true in the Minnesota and EKFC cohorts.Conclusion: Significant differences in SCr concentrations between the Minnesota and EKFC cohorts versus CRIC were observed in subjects with the same level of mGFR and equal demographic characteristics and can be explained by the difference in SCr calibration.Lay Summary: Standardization of serum creatinine (SCr) measurement is fundamental for estimating glomerular filtration rate (GFR). We used data with GFR measured by a reference method from three cohorts: Chronic Renal Insufficiency Cohort (CRIC, n = 1548), Minnesota cohort (n = 1093) and European Kidney Function Consortium cohort (EKFC; n = 7727). In the EKFC and Minnesota cohorts, SCr was measured by standardized methods, although SCr 'calibration' was more debatable in the CRIC. GFR was measured by the same method in the CRIC and Minnesota cohort. Then we matched 305 White subjects for sex, measured GFR (+/- 3 ml/min/1.73 m(2)), age (+/- 3 years) and body mass index (+/- 2.5 kg/m(2)). From these matched subjects we showed that the association between SCr and measured GFR was quite similar between subjects from the Minnesota and EKFC cohorts, but different between the CRIC and EKFC cohort and between the Minnesota cohort and CRIC. These differences lead to discrepancies in the analysis of the performance of different creatinine-based equations.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Cavalier, EtienneDepartment of Clinical Chemistry, University of Liège , CHU Sart Tilman, Liège , Belgium,University of Liège Hospital (author)
  • Björk, JonasLund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine,Skåne University Hospital(Swepub:lu)ymed-jbj (author)
  • Nyman, UlfLund University,Lunds universitet,Diagnostisk radiologi, Malmö,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Radiology Diagnostics, Malmö,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments(Swepub:lu)ront-uny (author)
  • Grubb, AndersLund University,Lunds universitet,Cystatin C, njursjukdom, amyloidos och antibiotika,Forskargrupper vid Lunds universitet,Cystatin C, renal disease, amyloidosis and antibiotics,Lund University Research Groups,Skåne University Hospital(Swepub:lu)kkem-agr (author)
  • Ebert, NatalieCharité Universitätsmedizin Berlin, Institute of Public Health , Berlin , Germany,Charité - University Medicine Berlin (author)
  • Schaeffner, ElkeCharité Universitätsmedizin Berlin, Institute of Public Health , Berlin , Germany,Charité - University Medicine Berlin (author)
  • Eriksen, Björn O.Section of Nephrology, University Hospital of North Norway and Metabolic and Renal Research Group, UiT The Arctic University of Norway , Tromsö , Norway (author)
  • Melsom, ToralfSection of Nephrology, University Hospital of North Norway and Metabolic and Renal Research Group, UiT The Arctic University of Norway , Tromsö , Norway (author)
  • Lamb, Edmund J.Clinical Biochemistry, East Kent Hospitals University NHS Foundation Trust , Canterbury , UK (author)
  • Mariat, ChristopheService de Néphrologie, Dialyse et Transplantation Rénale , Hôpital Nord, CHU de Saint-Etienne, France (author)
  • Dubourg, LaurenceNéphrologie, Dialyse, Hypertension et Exploration Fonctionnelle Rénale , Hôpital Edouard Herriot, Hospices Civils de Lyon, France (author)
  • Hansson, MagnusKarolinska Institutet,Karolinska University Hospital (author)
  • Littmann, KarinKarolinska Institute,Karolinska Institutet (author)
  • Sundin, Per-Ola,1971-Örebro University,Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Geriatrics, School of Medical Sciences, Örebro University , Örebro, Sweden(Swepub:oru)pasn (author)
  • Åkesson, AnnaLund University,Lunds universitet,Medicinsk strålningsfysik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medical Radiation Physics, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital(Swepub:lu)med-aa7 (author)
  • Larsson, AndersUppsala University,Uppsala universitet,Klinisk kemi(Swepub:uu)andlarss (author)
  • Rule, AndrewDivision of Nephrology and Hypertension, Mayo Clinic , Rochester, MN , USA,Mayo Clinic Minnesota (author)
  • Delanaye, PierreNephrology-Dialysis-Transplantation, University of Liège , CHU Sart Tilman, Liège, Belgium;Department of Nephrology-Dialysis-Apheresis , Hôpital Universitaire Carémeau, Nîmes, France (author)
  • Department of Public Health and Primary Care , KU Leuven Campus Kulak Kortrijk, Kortrijk , BelgiumCatholic University of Leuven (creator_code:org_t)

Related titles

  • In:Clinical Kidney Journal: Oxford University Press15:12, s. 2258-22652048-85052048-8513

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