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Sökning: WFRF:(Alonso Cotoner Carmen) > (2022) > Mucosal Plasma Cell...

  • Pardo-Camacho, CristinaLaboratory of Translational Mucosal Immunology, Digestive System Research Unit, Vall d'Hebron Institut de Recerca, Barcelona, Spain; Laboratory of Neuro-Immuno-Gastroenterology, Digestive System Research Unit, Vall d'Hebron Institut de Recerca, Barcelona, Spain; Facultat de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain (författare)

Mucosal Plasma Cell Activation and Proximity to Nerve Fibres Are Associated with Glycocalyx Reduction in Diarrhoea-Predominant Irritable Bowel Syndrome : Jejunal Barrier Alterations Underlying Clinical Manifestations

  • Artikel/kapitelEngelska2022

Förlag, utgivningsår, omfång ...

  • 2022-06-28
  • Basel :MDPI,2022
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:oru-101149
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-101149URI
  • https://doi.org/10.3390/cells11132046DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-187473URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

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Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding Agency: Spanish Government
  • Funding Agencies|Fondo Europeo de Desarrollo Regional (FEDER) [CP18/00116, PI19/01643, PI17/01443, PI15/00301, PI17/0190, CPII16/00031, CIBEREHD CB06/04/0021]; Fondo de Investigacion Sanitaria [CP18/00116, PI19/01643, PI17/01443, PI15/00301, PI17/0190, CPII16/00031, CIBEREHD CB06/04/0021]; Centro de Investigacion Biomedica en Red de Enfermedades Hepaticas y Digestivas (CIBEREHD), Instituto de Salud Carlos III, Subdireccion General de Investigacion Sanitaria, Ministerio de Economia y Competitividad [CP18/00116, PI19/01643, PI17/01443, PI15/00301, PI17/0190, CPII16/00031, CIBEREHD CB06/04/0021]; Ministerio de Educacion, Direccion General de Investigacion [SAF 2016-76648-R]; Agencia de Gestio dAjuts Universitaris i de Recerca, de la Generalitat de Catalunya [2014 SGR 1285]; Vall dHebron Institut de Recerca, Programa de becas predoctorales Amics de Vall dHebron [PRED-VHIR-2016-34, PRED-VHIR-2014-018]; Swedish Research Council [2019-00653]; European Unions Horizon research and innovation programme 2020 [848228]
  • Irritable bowel syndrome (IBS) is a disorder of brain-gut interaction characterised by abdominal pain and changes in bowel habits. In the diarrhoea subtype (IBS-D), altered epithelial barrier and mucosal immune activation are associated with clinical manifestations. We aimed to further evaluate plasma cells and epithelial integrity to gain understanding of IBS-D pathophysiology. One mucosal jejunal biopsy and one stool sample were obtained from healthy controls and IBS-D patients. Gastrointestinal symptoms, stress, and depression scores were recorded. In the jejunal mucosa, RNAseq and gene set enrichment analyses were performed. A morphometric analysis by electron microscopy quantified plasma cell activation and proximity to enteric nerves and glycocalyx thickness. Immunoglobulins concentration was assessed in the stool. IBS-D patients showed differential expression of humoral pathways compared to controls. Activation and proximity of plasma cells to nerves and IgG concentration were also higher in IBS-D. Glycocalyx thickness was lower in IBS-D compared to controls, and this reduction correlated with plasma cell activation, proximity to nerves, and clinical symptoms. These results support humoral activity and loss of epithelial integrity as important contributors to gut dysfunction and clinical manifestations in IBS-D. Additional studies are needed to identify the triggers of these alterations to better define IBS-D pathophysiology. 

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Ganda Mall, John-Peter,1988-Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Vall Hebron Inst Recerca, Spain(Swepub:liu)johga65 (författare)
  • Martínez, CristinaVascular and Renal Translational Research Group, Lleida Institute for Biomedical Research Dr. Pifarré. Foundation (IRBLleida), Lleida, Spain,Vasc & Renal Translat Res Grp, Spain (författare)
  • Pigrau, MarcLaboratory of Neuro-Immuno-Gastroenterology, Digestive System Research Unit, Vall d'Hebron Institut de Recerca, Barcelona, Spain; Facultat de Medicina, Universitat Autònoma de Barcelona, Spain (författare)
  • Expósito, ElbaLaboratory of Translational Mucosal Immunology, Digestive System Research Unit, Vall d'Hebron Institut de Recerca, Barcelona, Spain; Laboratory of Neuro-Immuno-Gastroenterology, Digestive System Research Unit, Vall d'Hebron Institut de Recerca, Barcelona, Spain (författare)
  • Albert-Bayo, MercéLaboratory of Translational Mucosal Immunology, Digestive System Research Unit, Vall d'Hebron Institut de Recerca, Barcelona, Spain (författare)
  • Melón-Ardanaz, ElisaLaboratory of Translational Mucosal Immunology, Digestive System Research Unit, Vall d'Hebron Institut de Recerca, Barcelona, Spain (författare)
  • Nieto, AdoraciónLaboratory of Neuro-Immuno-Gastroenterology, Digestive System Research Unit, Vall d'Hebron Institut de Recerca, Barcelona, Spain; Department of Gastroenterology, Vall d'Hebron Hospital Universitari, Barcelona, Spain,Vall Hebron Inst Recerca, Spain; Vall Hebron Hosp Univ, Spain (författare)
  • Rodiño-Janeiro, BrunoLaboratory of Neuro-Immuno-Gastroenterology, Digestive System Research Unit, Vall d'Hebron Institut de Recerca, Barcelona, Spain (författare)
  • Fortea, MarinaLaboratory of Translational Mucosal Immunology, Digestive System Research Unit, Vall d'Hebron Institut de Recerca, Barcelona, Spain (författare)
  • Guagnozzi, DanilaLaboratory of Translational Mucosal Immunology, Digestive System Research Unit, Vall d'Hebron Institut de Recerca, Barcelona, Spain; Laboratory of Neuro-Immuno-Gastroenterology, Digestive System Research Unit, Vall d'Hebron Institut de Recerca, Barcelona, Spain; Department of Gastroenterology, Vall d'Hebron Hospital Universitari, Barcelona, Spain,Vall Hebron Inst Recerca, Spain; Vall Hebron Inst Recerca, Spain; Vall Hebron Hosp Univ, Spain (författare)
  • Rodriguez-Urrutia, AmandaFacultat de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain; Department of Mental Health, Vall d'Hebron Hospital Universitari, Barcelona, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain,Univ Autonoma Barcelona, Spain; Vall Hebron Hosp Univ, Spain; Inst Salud Carlos III, Spain (författare)
  • de Torres, InésFacultat de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain; Department of Pathology, Hospital Universitari Vall d'Hebrón, Barcelona, Spain,Univ Autonoma Barcelona, Spain; Hosp Univ Vall Hebron, Spain (författare)
  • Santos-Briones, IgnacioFacultat Ciències de la Salut, Universitat Ramon LLull-Blanquerna, Barcelona, Spain,Univ Ramon LLull Blanquerna, Spain (författare)
  • Azpiroz, FernandoDepartment of Gastroenterology, Vall d'Hebron Hospital Universitari, Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Instituto de Salud Carlos III, Madrid, Spain,Vall Hebron Hosp Univ, Spain; Inst Salud Carlos III, Spain (författare)
  • Lobo, BeatrizLaboratory of Neuro-Immuno-Gastroenterology, Digestive System Research Unit, Vall d'Hebron Institut de Recerca, Barcelona, Spain; Facultat de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain; Department of Gastroenterology, Vall d'Hebron Hospital Universitari, Barcelona, Spain,Vall Hebron Inst Recerca, Spain; Univ Autonoma Barcelona, Spain; Vall Hebron Hosp Univ, Spain (författare)
  • Alonso-Cotoner, CarmenLaboratory of Neuro-Immuno-Gastroenterology, Digestive System Research Unit, Vall d'Hebron Institut de Recerca, Barcelona, Spain; Facultat de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain; Department of Gastroenterology, Vall d'Hebron Hospital Universitari, Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Instituto de Salud Carlos III, Madrid, Spain,Vall Hebron Inst Recerca, Spain; Univ Autonoma Barcelona, Spain; Vall Hebron Hosp Univ, Spain; Inst Salud Carlos III, Spain (författare)
  • Santos, JavierLaboratory of Neuro-Immuno-Gastroenterology, Digestive System Research Unit, Vall d'Hebron Institut de Recerca, Barcelona, Spain; Facultat de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain; Department of Gastroenterology, Vall d'Hebron Hospital Universitari, Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Instituto de Salud Carlos III, Madrid, Spain,Vall Hebron Inst Recerca, Spain; Univ Autonoma Barcelona, Spain; Vall Hebron Hosp Univ, Spain; Inst Salud Carlos III, Spain (författare)
  • González-Castro, Ana M.Laboratory of Translational Mucosal Immunology, Digestive System Research Unit, Vall d'Hebron Institut de Recerca, Barcelona, Spain; Laboratory of Neuro-Immuno-Gastroenterology, Digestive System Research Unit, Vall d'Hebron Institut de Recerca, Barcelona, Spain (författare)
  • Vicario, MariaLaboratory of Translational Mucosal Immunology, Digestive System Research Unit, Vall d'Hebron Institut de Recerca, Barcelona, Spain; Department of Gastrointestinal Health, Nestlé Institute of Health Sciences, Société des Produits Nestlé S.A., Nestlé Research, Vers-chez-les-Blanc, Lausanne, Switzerland (författare)
  • Laboratory of Translational Mucosal Immunology, Digestive System Research Unit, Vall d'Hebron Institut de Recerca, Barcelona, Spain; Laboratory of Neuro-Immuno-Gastroenterology, Digestive System Research Unit, Vall d'Hebron Institut de Recerca, Barcelona, Spain; Facultat de Medicina, Universitat Autònoma de Barcelona, Bellaterra, SpainAvdelningen för kirurgi, ortopedi och onkologi (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:CellsBasel : MDPI11:132073-4409

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  • Cells (Sök värdpublikationen i LIBRIS)

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