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  • Brook, Matthew SMRC-Versus Arthritis Centre for Musculoskeletal Ageing Research and NIHR Nottingham BRC, Centre of Metabolism, Ageing and Physiology (COMAP), School of Medicine, University of Nottingham, Derby, UK; School of Life Sciences, University of Nottingham, Nottingham, UK (author)

Neither myonuclear accretion nor a myonuclear domain size ceiling is a feature of the attenuated hypertrophic potential of aged human skeletal muscle

  • Article/chapterEnglish2023

Publisher, publication year, extent ...

  • 2022-09-09
  • Springer,2023
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:oru-101167
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-101167URI
  • https://doi.org/10.1007/s11357-022-00651-yDOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding agencies:The Physiological SocietyDunhill Medical Trust R264/1112UK Research & Innovation (UKRI) Medical Research Council UK (MRC) European Commission CIC12019  Medical Research Council as part of the MRC-ARUK Centre for Musculoskeletal Ageing Research MR/R502364/1 MR/P021220/1 
  • Ageing limits growth capacity of skeletal muscle (e.g. in response to resistance exercise), but the role of satellite cell (SC) function in driving this phenomenon is poorly defined. Younger (Y) (~ 23 years) and older (O) men (~ 69 years) (normal-weight BMI) underwent 6 weeks of unilateral resistance exercise training (RET). Muscle biopsies were taken at baseline and after 3-/6-week training. We determined muscle size by fibre CSA (and type), SC number, myonuclei counts and DNA synthesis (via D2O ingestion). At baseline, there were no significant differences in fibre areas between Y and O. RET increased type I fibre area in Y from baseline at both 3 weeks and 6 weeks (baseline: 4509 ± 534 µm2, 3 weeks; 5497 ± 510 µm2 P < 0.05, 6 weeks; 5402 ± 352 µm2 P < 0.05), whilst O increased from baseline at 6 weeks only (baseline 5120 ± 403 µm2, 3 weeks; 5606 ± 620 µm2, 6 weeks; 6017 ± 482 µm2 P < 0.05). However, type II fibre area increased from baseline in Y at both 3 weeks and 6 weeks (baseline: 4949 ± 459 µm2, 3 weeks; 6145 ± 484 µm2 (P < 0.01), 6 weeks; 5992 ± 491 µm2 (P < 0.01), whilst O showed no change (baseline 5210 ± 410 µm2, 3 weeks; 5356 ± 535 µm2 (P = 0.9), 6 weeks; 5857 ± 478 µm2 (P = 0.1). At baseline, there were no differences in fibre myonuclei number between Y and O. RET increased type I fibre myonuclei number from baseline in both Y and O at 3 weeks and 6 weeks with RET (younger: baseline 2.47 ± 0.16, 3 weeks; 3.19 ± 0.16 (P < 0.001), 6 weeks; 3.70 ± 0.29 (P < 0.0001); older: baseline 2.29 ± 0.09, 3 weeks; 3.01 ± 0.09 (P < 0.001), 6 weeks; 3.65 ± 0.18 (P < 0.0001)). Similarly, type II fibre myonuclei number increased from baseline in both Y and O at 3 weeks and 6 weeks (younger: baseline 2.49 ± 0.14, 3 weeks; 3.31 ± 0.21 (P < 0.001), 6 weeks; 3.86 ± 0.29 (P < 0.0001); older: baseline 2.43 ± 0.12, 3 weeks; 3.37 ± 0.12 (P < 0.001), 6 weeks; 3.81 ± 0.15 (P < 0.0001)). DNA synthesis rates %.d-1 exhibited a main effect of training but no age discrimination. Declines in myonuclei addition do not underlie impaired muscle growth capacity in older humans, supporting ribosomal and proteostasis impairments as we have previously reported.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Wilkinson, Daniel JMRC-Versus Arthritis Centre for Musculoskeletal Ageing Research and NIHR Nottingham BRC, Centre of Metabolism, Ageing and Physiology (COMAP), School of Medicine, University of Nottingham, Derby, UK (author)
  • Tarum, JanelleSchool of Health Sciences, Örebro University, Örebro, Sweden (author)
  • Mitchell, Kyle WMRC-Versus Arthritis Centre for Musculoskeletal Ageing Research and NIHR Nottingham BRC, Centre of Metabolism, Ageing and Physiology (COMAP), School of Medicine, University of Nottingham, Derby, UK (author)
  • Lund, Jonathan LMRC-Versus Arthritis Centre for Musculoskeletal Ageing Research and NIHR Nottingham BRC, Centre of Metabolism, Ageing and Physiology (COMAP), School of Medicine, University of Nottingham, Derby, UK (author)
  • Phillips, Bethan EMRC-Versus Arthritis Centre for Musculoskeletal Ageing Research and NIHR Nottingham BRC, Centre of Metabolism, Ageing and Physiology (COMAP), School of Medicine, University of Nottingham, Derby, UK (author)
  • Szewczyk, Nathaniel JMRC-Versus Arthritis Centre for Musculoskeletal Ageing Research and NIHR Nottingham BRC, Centre of Metabolism, Ageing and Physiology (COMAP), School of Medicine, University of Nottingham, Derby, UK (author)
  • Kadi, Fawzi,1970-Örebro universitet,Institutionen för hälsovetenskaper(Swepub:oru)fki (author)
  • Greenhaff, Paul LMRC-Versus Arthritis Centre for Musculoskeletal Ageing Research and NIHR Nottingham BRC, Centre of Metabolism, Ageing and Physiology (COMAP), School of Medicine, University of Nottingham, Derby, UK; School of Life Sciences, University of Nottingham, Nottingham, UK (author)
  • Smith, KenMRC-Versus Arthritis Centre for Musculoskeletal Ageing Research and NIHR Nottingham BRC, Centre of Metabolism, Ageing and Physiology (COMAP), School of Medicine, University of Nottingham, Derby, UK (author)
  • Atherton, Philip JMRC-Versus Arthritis Centre for Musculoskeletal Ageing Research and NIHR Nottingham BRC, Centre of Metabolism, Ageing and Physiology (COMAP), School of Medicine, University of Nottingham, Derby, UK (author)
  • MRC-Versus Arthritis Centre for Musculoskeletal Ageing Research and NIHR Nottingham BRC, Centre of Metabolism, Ageing and Physiology (COMAP), School of Medicine, University of Nottingham, Derby, UK; School of Life Sciences, University of Nottingham, Nottingham, UKMRC-Versus Arthritis Centre for Musculoskeletal Ageing Research and NIHR Nottingham BRC, Centre of Metabolism, Ageing and Physiology (COMAP), School of Medicine, University of Nottingham, Derby, UK (creator_code:org_t)

Related titles

  • In:GeroScience: Springer45, s. 451-4622509-27152509-2723

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