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Genetic and Environ...
Genetic and Environmental Contribution to the Co-Occurrence of Endocrine-Metabolic Disorders and Depression : A Nationwide Swedish Study of Siblings
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- Leone, Marica (author)
- Janssen Pharmaceutical Companies of Johnson & Johnson, Solna, Sweden; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Solna, Sweden
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- Kuja-Halkola, Ralf (author)
- Karolinska Institutet
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- Leval, Amy (author)
- Janssen Pharmaceutical Companies of Johnson & Johnson, Solna, Sweden; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Solna, Sweden
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- Butwicka, Agnieszka (author)
- Karolinska Institutet
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- Skov, Jakob (author)
- Department of Molecular Medicine and Surgery, Karolinska Institutet, Solna, Sweden; Department of Medicine, Karlstad Central Hospital, Karlstad, Sweden
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- Zhang, Ruyue (author)
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Solna, Sweden
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- Liu, Shengxin (author)
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Solna, Sweden
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- Larsson, Henrik, 1975- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Solna, Sweden
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- Bergen, Sarah E. (author)
- Karolinska Institutet
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(creator_code:org_t)
- HighWire Press, 2022
- 2022
- English.
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In: American Journal of Psychiatry. - : HighWire Press. - 0002-953X .- 1535-7228. ; 179:11, s. 824-832
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- OBJECTIVE: Depression is common in individuals with endocrine-metabolic disorders and vice versa, and a better understanding of the underlying factors contributing to the comorbidity of these disorders is needed. This study investigated the familial coaggregation of depression and endocrine-metabolic disorders and estimated the contribution of genetic and environmental factors to their co-occurrence.METHODS: This population-based cohort study included 2.2 million individuals born in Sweden between 1973 and 1996, with follow-up through 2013. Participants were linked to their biological parents, allowing identification of full siblings, maternal half siblings, and paternal half siblings. Diagnoses of depression and endocrine-metabolic conditions were investigated, with the latter grouped into autoimmune disorders (autoimmune hypothyroidism, Graves' disease, and type 1 diabetes) and non-autoimmune disorders (type 2 diabetes, obesity, and polycystic ovary syndrome). Logistic regression and Cox regression were used to estimate the associations between endocrine-metabolic disorders and depression within the same individual and across siblings. Quantitative genetic modeling was performed to investigate the relative contribution of genetic and environmental influences.RESULTS: Individuals with endocrine-metabolic disorders had a significantly higher risk of depression, with odds ratios ranging from 1.43 (95% CI=1.30, 1.57) for Graves' disease to 3.48 (95% CI=3.25, 3.72) for type 2 diabetes. Increased risks extended to full and half siblings. These correlations were mainly explained by shared genetic influences for non-autoimmune conditions, and by nonshared environmental factors for autoimmune disorders, especially for type 1 diabetes.CONCLUSIONS: These findings provide phenotypic and etiological insights into the co-occurrence of depression and various endocrine-metabolic conditions, which could guide future research aiming at identifying pathophysiological mechanisms and intervention targets.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Keyword
- Depressive Disorders
- Metabolism
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Leone, Marica
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Kuja-Halkola, Ra ...
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Leval, Amy
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Butwicka, Agnies ...
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Skov, Jakob
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Zhang, Ruyue
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show more...
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Liu, Shengxin
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Larsson, Henrik, ...
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Bergen, Sarah E.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Psychiatry
- Articles in the publication
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American Journal ...
- By the university
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Örebro University
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Karolinska Institutet