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  • Djekic, DemirDepartment of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg Sweden; Cardiology unit, Sahlgrenska University Hospital/Östra, Gothenburg, Sweden (författare)

Body Mass Index in Adolescence and Long-Term Risk of Early Incident Atrial Fibrillation and Subsequent Mortality, Heart Failure, and Ischemic Stroke

  • Artikel/kapitelEngelska2022

Förlag, utgivningsår, omfång ...

  • John Wiley & Sons,2022
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:oru-101851
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-101851URI
  • https://doi.org/10.1161/JAHA.121.025984DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

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Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding agency:Swedish state under an agreement concerning research and education of physicians ALFGBG-717211 
  • Background: We sought to determine the role of obesity in adolescent men on development of atrial fibrillation (AF) and subsequent associated clinical outcomes in subjects diagnosed with AF.Methods and Results: We conducted a nationwide, register-based, cohort study of 1 704 467 men (mean age, 18.3±0.75 years) enrolled in compulsory military service in Sweden from 1969 through 2005. Height and weight, blood pressure, fitness, muscle strength, intelligence quotient, and medical disorders were recorded at baseline. Records obtained from the National Inpatient Registry and the Cause of Death Register were used to determine incidence and clinical outcomes of AF. During a median follow-up of 32 years (interquartile range, 24-41 years), 36 693 cases (mean age at diagnosis, 52.4±10.6 years) of AF were recorded. The multivariable-adjusted hazard ratio (HR) for AF increased from 1.06 (95% CI, 1.03-1.10) in individuals with body mass index (BMI) of 20.0 to <22.5 kg/m2 to 3.72 (95% CI, 2.44-5.66) among men with BMI of 40.0 to 50.0 kg/m2, compared with those with BMI of 18.5 to <20.0 kg/m2. During a median follow-up of ≈6 years in patients diagnosed with AF, we identified 3767 deaths, 3251 cases of incident heart failure, and 921 cases of ischemic stroke. The multivariable-adjusted HRs for all-cause mortality, incident heart failure, and ischemic stroke in AF-diagnosed men with baseline BMI >30 kg/m2 compared with those with BMI <20 kg/m2 were 2.86 (95% CI, 2.30-3.56), 3.42 (95% CI, 2.50-4.68), and 2.34 (95% CI, 1.52-3.61), respectively.Conclusions: Increasing BMI in adolescent men is strongly associated with early AF, and with subsequent worse clinical outcomes in those diagnosed with AF with respect to all-cause mortality, incident heart failure, and ischemic stroke.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Lindgren, MartinDepartment of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg Sweden; Cardiology unit, Sahlgrenska University Hospital/Östra, Gothenburg, Sweden (författare)
  • Åberg, N. DavidDepartment of Internal Medicine Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Department of Acute Medicine and Geriatrics (SU/Sahlgrenska), Region Västra Götaland, Sahlgrenska University Hospital, Gothenburg, Sweden (författare)
  • Åberg, MariaSchool of Public Health and Community, Medicine/Primary Health Care Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Region Västra Götaland Regionhälsan, Gothenburg, Sweden (författare)
  • Fengsrud, Espen,1970-Örebro universitet,Institutionen för medicinska vetenskaper,Department of Cardiology, Örebro University, Örebro, Sweden(Swepub:oru)efd (författare)
  • Poci, DritanDepartment of Clinical Physiology, Institute of Medicine at the Sahlgrenska Academy, Sahlgrenska University Hospita,l Gothenburg, Sweden (författare)
  • Adiels, MartinCardiology unit, Sahlgrenska University Hospital/Östra, Gothenburg, Sweden (författare)
  • Rosengren, AnnikaDepartment of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg Sweden; Cardiology unit, Sahlgrenska University Hospital/Östra, Gothenburg, Sweden (författare)
  • Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg Sweden; Cardiology unit, Sahlgrenska University Hospital/Östra, Gothenburg, SwedenDepartment of Internal Medicine Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Department of Acute Medicine and Geriatrics (SU/Sahlgrenska), Region Västra Götaland, Sahlgrenska University Hospital, Gothenburg, Sweden (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Journal of the American Heart Association: John Wiley & Sons11:212047-9980

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