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Clinical Impact of Influenza Vaccination after ST- and Non-ST-segment elevation Myocardial Infarction Insights from the IAMI trial
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- Fröbert, Ole, 1964- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Örebro University, Faculty of Health, Department of Cardiology, Örebro, Örebro, Sweden,Orebro Univ, Sweden; Orebro Univ, Sweden
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- Götberg, Matthias (författare)
- Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital
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- Erlinge, David (författare)
- Lund University,Lunds universitet,Molekylär kardiologi,Forskargrupper vid Lunds universitet,Molecular Cardiology,Lund University Research Groups,Skåne University Hospital
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- Akhtar, Zubair (författare)
- International Centre for Diarrhoeal Disease Research, Bangladesh, (icddr,b) Dhaka, Banglades,International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Dhaka, Bangladesh; The Kirby Institute, UNSW Medicine, University of New South Wales, NSW, Sydney, Australia,Int Ctr Diarrhoeal Dis Res, Bangladesh; Univ New South Wales, Australia
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- Christiansen, Evald H. (författare)
- Department of Cardiology, Aarhus University Hospital, Aarhus, Aarhus, Denmark,Aarhus Univ Hosp, Denmark
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- MacIntyre, Chandini R. (författare)
- The Kirby Institute, UNSW Medicine, University of New South Wales, Sydney, New South Wales, Australia
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- Oldroyd, Keith G. (författare)
- Institute of Cardiovascular and Medical Sciences, University of Glasgow, United Kingdom and West of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Clydebank, Scotland, Glasgow, United Kingdom,Univ Glasgow, Scotland; Golden Jubilee Natl Hosp, Scotland
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- Motovska, Zuzana (författare)
- Cardiocenter, Third Faculty of Medicine, Charles University, Prague, Czech Republic and University Hospital Kralovske Vinohrady, Bohemia, Prague, Czech Republic,Charles Univ Prague, Czech Republic; Univ Hosp Kralovske Vinohrady, Czech Republic
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- Erglis, Andrejs (författare)
- Pauls Stradins Clinical University Hospital, University of Latvia, Riga, Riga, Latvia,Univ Latvia, Latvia
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- Moer, Rasmus (författare)
- LHL-sykehuset Gardermoen, Ostiandet, Oslo, Norway
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- Hlinomaz, Ota (författare)
- nternational clinical research center, St. Anne University Hospital and Masaryk University, South Moravian, Brno, Czech Republic,Masaryk Univ, Czech Republic
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- Jakobsen, Lars (författare)
- Department of Cardiology, Aarhus University Hospital, Aarhus, Aarhus, Denmark,Aarhus Univ Hosp, Denmark
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- Engstrøm, Thomas (författare)
- Rigshospitalet, University of Copenhagen, Copenhagen, Copenhagen, Denmark,Univ Copenhagen, Denmark,Copenhagen University Hospital
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- Jensen, Lisette O. (författare)
- Department of Cardiology, Odense University Hospital, Odense, Odense, Denmark,Odense Univ Hosp, Denmark
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- Fallesen, Christian O. (författare)
- Department of Cardiology, Odense University Hospital, Odense, Odense, Denmark,Odense Univ Hosp, Denmark
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- Jensen, Svend E. (författare)
- Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark and Department of Clinical Medicine, Aalborg University, Kommune, Aalborg, Denmark,Aalborg Univ Hosp, Denmark; Aalborg Univ, Denmark
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- Angerås, Oskar, 1976 (författare)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,Sahlgrenska University Hospital,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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- Calais, Fredrik, 1971- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Örebro University, Faculty of Health, Department of Cardiology, Örebro, Örebro, Sweden,Orebro Univ, Sweden
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- Kåregren, Amra (författare)
- Västmanlands sjukhus Västerås, Västmanland, Västerås, Sweden,Västmanland Hospital
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- Lauermann, Jörg (författare)
- Linköping University,Linköpings universitet,Institutionen för hälsa, medicin och vård,Medicinska fakulteten,Dept Cardiol, Jönköping, Region Jönköping County, Sweden
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- Mokhtari, Arash (författare)
- Lund University,Lunds universitet,NPWT teknologin,Forskargrupper vid Lunds universitet,Skonsammare hjärtkirurgi,NPWT technology,Lund University Research Groups,Less invasive cardiac surgery,Skåne University Hospital
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- Nilsson, Johan (författare)
- Umeå University,Umeå universitet,Kardiologi,Umea Univ, Sweden
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- Persson, Jonas (författare)
- Karolinska Institutet,Karolinska Institute,Danderyd Hospital
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- Stalby, Per (författare)
- Department of Cardiology, Karlstad Central Hospital, Värmland, Karlstad, Sweden,Karlstad Cent Hosp, Sweden
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- Islam, Abu K. M. M. (författare)
- National Institute of Cardiovascular Diseases, Sher-e-Bangla Nagar, Dhaka, Dhaka, Bangladesh,Natl Inst Cardiovasc Dis, Bangladesh
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- Rahman, Afzalur (författare)
- National Institute of Cardiovascular Diseases, Sher-e-Bangla Nagar, Dhaka, Dhaka, Bangladesh,Natl Inst Cardiovasc Dis, Bangladesh
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- Malik, Fazila (författare)
- National Heart Foundation Hospital & Research Institute, Dhaka, Dhaka, Bangladesh,Natl Heart Fdn Hosp & Res Inst, Bangladesh
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- Choudhury, Sohel (författare)
- National Heart Foundation Hospital & Research Institute, Dhaka, Dhaka, Bangladesh,Natl Heart Fdn Hosp & Res Inst, Bangladesh
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- Collier, Timothy (författare)
- Department of Medical Statistics, London School of Hygiene and Tropical Medicine, London, London, United Kingdom,London Sch Hyg & Trop Med, England
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- Pocock, Stuart J. (författare)
- Department of Medical Statistics, London School of Hygiene and Tropical Medicine, London, London, United Kingdom,London Sch Hyg & Trop Med, England
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- Pernow, John (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital
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(creator_code:org_t)
- Elsevier, 2023
- 2023
- Engelska.
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Ingår i: American Heart Journal. - : Elsevier. - 0002-8703 .- 1097-6744. ; 255, s. 82-89
- Relaterad länk:
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http://dx.doi.org/10...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- BACKGROUND: Influenza vaccination early after myocardial infarction (MI) improves prognosis but vaccine effectiveness may differ dependent on type of MI.METHODS: A total of 2571 participants were prospectively enrolled in the IAMI trial and randomly assigned to receive in-hospital inactivated influenza vaccine or saline placebo. The trial was conducted at 30 centers in 8 countries from October 1, 2016 to March 1, 2020. Here we report vaccine effectiveness in the 2467 participants with ST-segment elevation MI (STEMI, n=1348) or non-ST-segment elevation MI (NSTEMI, n=1119). The primary endpoint was the composite of all-cause death, MI, or stent thrombosis at 12 months. Cumulative incidence of the primary and key secondary endpoints by randomized treatment and NSTEMI/STEMI was estimated using the Kaplan-Meier method. Treatment effects were evaluated with formal interaction testing to assess for effect modification.RESULTS: Baseline risk was higher in participants with NSTEMI. In the NSTEMI group the primary endpoint occurred in 6.5% of participants assigned to influenza vaccine and 10.5% assigned to placebo (hazard ratio [HR], 0.60; 95% CI, 0.39-0.91), compared to 4.1% assigned to influenza vaccine and 4.5% assigned to placebo in the STEMI group (HR, 0.90; 95% CI, 0.54-1.50, P=0.237 for interaction). Similar findings were seen for the key secondary endpoints of all-cause death and cardiovascular death. The Kaplan-Meier risk difference in all-cause death at 1 year was more pronounced in participants with NSTEMI (NSTEMI: HR, 0.47; 95% CI 0.28-0.80, STEMI: HR, 0.86; 95% CI, 0.43-1.70, interaction P=0.028).CONCLUSIONS: The beneficial effect of influenza vaccination on adverse cardiovascular events may be enhanced in patients with NSTEMI compared to those with STEMI.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- Influenza vaccination
- Myocardial infarction
- Percutaneous coronary intervention
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- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Fröbert, Ole, 19 ...
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Götberg, Matthia ...
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Erlinge, David
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Akhtar, Zubair
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Christiansen, Ev ...
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MacIntyre, Chand ...
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visa fler...
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Oldroyd, Keith G ...
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Motovska, Zuzana
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Erglis, Andrejs
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Moer, Rasmus
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Hlinomaz, Ota
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Jakobsen, Lars
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Engstrøm, Thomas
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Jensen, Lisette ...
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Fallesen, Christ ...
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Jensen, Svend E.
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Angerås, Oskar, ...
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Calais, Fredrik, ...
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Kåregren, Amra
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Lauermann, Jörg
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Mokhtari, Arash
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Nilsson, Johan
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Persson, Jonas
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Stalby, Per
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Islam, Abu K. M. ...
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Rahman, Afzalur
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Malik, Fazila
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Choudhury, Sohel
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Collier, Timothy
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Pocock, Stuart J ...
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Pernow, John
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
- Artiklar i publikationen
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American Heart J ...
- Av lärosätet
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Örebro universitet
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Umeå universitet
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Linköpings universitet
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Lunds universitet
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Karolinska Institutet
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Göteborgs universitet