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  • Strom, Nora I.Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany; Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Region Stockholm, Sweden; Department of Biomedicine, Aarhus University, Aarhus, Denmark (författare)

Meta-analysis of genome-wide association studies of hoarding symptoms in 27,537 individuals

  • Artikel/kapitelEngelska2022

Förlag, utgivningsår, omfång ...

  • 2022-11-15
  • Springer Nature,2022
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:oru-102259
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-102259URI
  • https://doi.org/10.1038/s41398-022-02248-7DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:151231038URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

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  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding agencies:Medical Research (ZonMW): Netherlands Twin Registry Repository NWO 480-15-001/674Biobank-based integrative omics study (BIOS) - BBMRI-NL (NWO) 184.021.007 184.033.111 European Science Council (ERC) Genetics of Mental Illness (ERC Advanced) 230374Royal Netherlands Academy of Science Professor Award PAH/6635Rutgers University Cell and DNA Repository NIMH U24 MH068457-06Avera Institute, Sioux Falls, South Dakota (USA)United States Department of Health & Human Services National Institutes of Health (NIH) - USA R01 HD042157-01A1 1RC2 MH089951 UK Research & Innovation (UKRI) Medical Research Council UK (MRC)Versus ArthritisChronic Disease Research Foundation (CDRF)Zoe Ltd.National Institute for Health and Care Research (NIHR) Clinical Research Network (CRN)Biomedical Research Centre based at Guy's and St Thomas' NHS Foundation Trust in partnership with King's College LondonCanadian Institutes of Health Research (CIHR) MOP-93696 MOP-106573Alberta Innovates Translational Health Chair in Child and Youth Mental HealthOpen Access Publication Fund of Humboldt-Universitat zu BerlinNetherlands Organization for Scientific Research (NWO)Correction: Meta-analysis of genome-wide association studies of hoarding symptoms in 27,537 individuals. Strom, N.I., Smit, D.J.A., Silzer, T. et al. Transl Psychiatry 12, 521 (2022). https://doi.org/10.1038/s41398-022-02288-z
  • Hoarding Disorder (HD) is a mental disorder characterized by persistent difficulties discarding or parting with possessions, often resulting in cluttered living spaces, distress, and impairment. Its etiology is largely unknown, but twin studies suggest that it is moderately heritable. In this study, we pooled phenotypic and genomic data from seven international cohorts (N = 27,537 individuals) and conducted a genome wide association study (GWAS) meta-analysis of parent- or self-reported hoarding symptoms (HS). We followed up the results with gene-based and gene-set analyses, as well as leave-one-out HS polygenic risk score (PRS) analyses. To examine a possible genetic association between hoarding symptoms and other phenotypes we conducted cross-trait PRS analyses. Though we did not report any genome-wide significant SNPs, we report heritability estimates for the twin-cohorts between 26-48%, and a SNP-heritability of 11% for an unrelated sub-cohort. Cross-trait PRS analyses showed that the genetic risk for schizophrenia and autism spectrum disorder were significantly associated with hoarding symptoms. We also found suggestive evidence for an association with educational attainment. There were no significant associations with other phenotypes previously linked to HD, such as obsessive-compulsive disorder, depression, anxiety, or attention-deficit hyperactivity disorder. To conclude, we found that HS are heritable, confirming and extending previous twin studies but we had limited power to detect any genome-wide significant loci. Much larger samples will be needed to further extend these findings and reach a "gene discovery zone". To move the field forward, future research should not only include genetic analyses of quantitative hoarding traits in larger samples, but also in samples of individuals meeting strict diagnostic criteria for HD, and more ethnically diverse samples.

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Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Smit, Dirk J. A.Department of Psychiatry, Amsterdam University Medical Centers, Amsterdam, The Netherlands; Amsterdam Neuroscience, Amsterdam, The Netherlands (författare)
  • Silzer, TalisaDepartment of Psychiatry, Hospital for Sick Children, Toronto, ON, Canada (författare)
  • Iyegbe, ConradDepartment of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, England; Department of Genetics and Genomic Sciences, Icahn School of Medicine, Mount Sinai, New York, USA (författare)
  • Burton, Christie L.Department of Psychiatry, Hospital for Sick Children, Toronto, ON, Canada (författare)
  • Pool, RenéDepartment of Biological Psychology, Vrije Universiteit, Amsterdam, Netherlands (författare)
  • Lemire, MathieuDepartment of Psychiatry, Hospital for Sick Children, Toronto, ON, Canada (författare)
  • Crowley, James J.Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Region Stockholm, Sweden; Departments of Genetics and Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, USA (författare)
  • Hottenga, Jouke-JanNetherlands Twin Register, Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands (författare)
  • Ivanov, Volen Z.Karolinska Institutet (författare)
  • Larsson, Henrik,1975-Karolinska Institutet,Örebro universitet,Institutionen för medicinska vetenskaper,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden(Swepub:oru)hiln (författare)
  • Lichtenstein, PaulKarolinska Institutet (författare)
  • Magnusson, PatrikKarolinska Institutet (författare)
  • Rück, ChristianKarolinska Institutet (författare)
  • Schachar, Russell J.Department of Psychiatry, Hospital for Sick Children, Toronto, ON, Canada (författare)
  • Wu, Hei ManDepartment of Genetics and Genomic Sciences, Icahn School of Medicine, Mount Sinai, New York, USA (författare)
  • Meier, Sandra M.Department of Psychiatry, Dalhousie University, Halifax, NS, Canada; Community Health & Epidemiology, Dalhousie University, NS, Dalhousie, Canada (författare)
  • Crosbie, JenniferDepartment of Psychiatry, Hospital for Sick Children, Toronto, ON, Canada (författare)
  • Arnold, Paul D.The Mathison Centre for Mental Health Research & Education, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada; Departments of Psychiatry and Medical Genetics, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada (författare)
  • Mattheisen, ManuelInstitute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany; Department of Psychiatry, Dalhousie University, Halifax, NS, Canada; Community Health & Epidemiology, Dalhousie University, NS, Dalhousie, Canada (författare)
  • Boomsma, Dorret I.Netherlands Twin Register, Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands; Amsterdam Public Health Research Institute, Amsterdam, The Netherlands; Amsterdam Reproduction and Development Research Institute, Amsterdam, The Netherlands (författare)
  • Mataix-Cols, DavidKarolinska Institutet (författare)
  • Cath, DanielleRijksuniversiteit Groningen and Department of Psychiatry, University Medical Center Groningen, Groningen, Netherlands; Department of specialized training, Drenthe Mental Health Care Institute, Assen, The Netherlands (författare)
  • Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany; Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Region Stockholm, Sweden; Department of Biomedicine, Aarhus University, Aarhus, DenmarkDepartment of Psychiatry, Amsterdam University Medical Centers, Amsterdam, The Netherlands; Amsterdam Neuroscience, Amsterdam, The Netherlands (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Translational Psychiatry: Springer Nature12:12158-3188

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