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Cancer risk in pati...
Cancer risk in patients with diverticular disease : A nationwide cohort study
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- Ma, Wenjie (författare)
- Clinical and Translational Epidemiology Unit and Division of Gastroenterology, Massachusetts General Hospital, Boston MA, USA,Massachusetts Gen Hosp, Clin & Translat Epidemiol Unit, Boston, MA 02114 USA.;Massachusetts Gen Hosp, Div Gastroenterol, Boston, MA 02114 USA.
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- Walker, Marjorie M. (författare)
- Department of Anatomical Pathology, Faculty of Health and Medicine, College of Health, Medicine and Wellbeing, University of Newcastle, Newcastle, Australia,Univ Newcastle, Coll Hlth Med & Wellbeing, Fac Hlth & Med, Dept Anat Pathol, Newcastle, NSW, Australia.
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- Thuresson, Marcus (författare)
- Statisticon AB, Uppsala, Sweden.
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- Roelstraete, Bjorn (författare)
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.
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- Sköldberg, Filip (författare)
- Uppsala universitet,Gastrointestinalkirurgi
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- Olén, Ola (författare)
- Karolinska Institutet
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- Strate, Lisa L. (författare)
- Division of Gastroenterology, University of Washington, Seattle WA, USA,Univ Washington, Div Gastroenterol, Seattle, WA 98195 USA.
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- Chan, Andrew T. (författare)
- Clinical and Translational Epidemiology Unit and Division of Gastroenterology, Massachusetts General Hospital, Boston MA, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston MA, USA; Cancer Center, Massachusetts General Hospital, Boston MA, USA,Massachusetts Gen Hosp, Clin & Translat Epidemiol Unit, Boston, MA 02114 USA.;Massachusetts Gen Hosp, Div Gastroenterol, Boston, MA 02114 USA.;Brigham & Womens Hosp, Dept Med, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA.;Harvard Med Sch, Boston, MA 02115 USA.;Harvard TH Chan Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA USA.;Massachusetts Gen Hosp, Canc Ctr, Boston, MA 02114 USA.
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- Ludvigsson, Jonas F., 1969- (författare)
- Karolinska Institutet
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Clinical and Translational Epidemiology Unit and Division of Gastroenterology, Massachusetts General Hospital, Boston MA, USA Massachusetts Gen Hosp, Clin & Translat Epidemiol Unit, Boston, MA 02114 USA;Massachusetts Gen Hosp, Div Gastroenterol, Boston, MA 02114 USA. (creator_code:org_t)
- 2022
- 2022
- Engelska.
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Ingår i: Journal of the National Cancer Institute. - : Oxford University Press. - 0027-8874 .- 1460-2105.
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background: There are little data on diverticular disease and cancer development other than colorectal cancer.Methods: We conducted a population-based, matched cohort study with linkage of nationwide registers to the Epidemiology Strengthened by histoPathology Reports in Sweden histopathology cohort. We included 75 704 patients with a diagnosis of diverticular disease and colorectal histopathology and 313 480 reference individuals from the general population matched on age, sex, calendar year, and county. Cox proportional hazards models estimated multivariable-adjusted hazard ratios (HRs) for associations between diverticular disease and overall cancer and specific cancers.Results: Over a median follow-up of 6 years, we documented 12 846 incident cancers among patients with diverticular disease and 43 354 incident cancers among reference individuals from the general population. Compared with reference individuals, patients with diverticular disease had statistically significantly increased overall cancer incidence (24.5 vs 18.1 per 1000 person-years), equivalent to 1 extra cancer case in 16 individuals with diverticular disease followed-up for 10 years. After adjusting for covariates, having a diagnosis of diverticular disease was associated with a 33% increased risk of overall cancer (95% confidence interval [CI] = 1.31 to 1.36). The risk increases also persisted compared with siblings as secondary comparators (HR = 1.26, 95% CI = 1.21 to 1.32). Patients with diverticular disease also had an increased risk of specific cancers, including colon cancer (HR = 1.71, 95% CI = 1.60 to 1.82), liver cancer (HR = 1.72, 95% CI = 1.41 to 2.10), pancreatic cancer (HR = 1.62, 95% CI = 1.42 to 1.84), and lung cancer (HR = 1.50, 95% CI = 1.39 to 1.61). The increase in colorectal cancer risk was primarily restricted to the first year of follow-up, and especially early cancer stages.Conclusions: Patients with diverticular disease who have colorectal histopathology have an increased risk of overall incident cancer.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
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