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Sökning: id:"swepub:oai:DiVA.org:oru-102603" > Expert opinion on t...

  • Hillert, J.Karolinska Institutet, Stockholm, Sweden (författare)

Expert opinion on the use of contraception in people with multiple sclerosis

  • Artikel/kapitelEngelska2022

Förlag, utgivningsår, omfång ...

  • Sage Publications,2022
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:oru-102603
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-102603URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:vet swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding agencies:Merck KGaA, Darmstadt, GermanyMerck Healthcare KGaA, Darmstadt, Germany
  • Introduction: The most appropriate use, type, and timing of contraception in people with multiple sclerosis (PwMS) is poorly understood, and specific guidance is absent.Aims  and  Objectives: To  provide  insight  into  potential  clinical  guidelines for the use of contraception by PwMS through development  of  recommendations  by a  consensus-based  program  led  by international clinical experts.Methods:  A  multidisciplinary  steering  committee  (SC)  of  13  international expert healthcare professionals (HCPs) identified 15 key clinical questions on the use of contraception in PwMS, which addressed issues relating to patient-centred care, selection of contraception for PwMS, and time needed to use contraception since the last dose of disease modifying therapies (DMTs). Twenty-five clinical recommendations  addressing  the  questions  were  drafted  using evidence obtained from a comprehensive systematic literature  review  combined  with expert  opinion  from  the  SC.  An  extended faculty of 32 HCPs from 18 countries including a patient association representative, and the SC members (n=12), voted on the   recommendations.   Consensus   on   recommendations   was   achieved when  ⩾75%  of  respondents  expressed  an  agreement  score of 7–9, on a 9-point scale.Results: Overall, consensus was achieved on 24 out of 25 clinical recommendations. In detail, consensus in the range of 90–100% was  achieved on 11  recommendations,  12  recommendations  achieved  80–89%  consensus,  and 1  recommendation  achieved  75–79%  consensus  (n=44).  The  strength  of recommendations  ranged from 7–9. The one statement failing to achieve consensus scored 74.1%. Clinical recommendations are provided on the process of prescribing contraception for PwMS, including the recommended types of HCPs involved and optimal topics to discuss; the range of contraceptive options and the key considerations involved in selecting an appropriate method of contraception; and the timing of starting and stopping contraception in relation to the use of DMTs.Conclusions: These  expert  recommendations  were  based  on  a  robust consensus approach, providing timely and practical guidance on the use of contraception for HCPs treating PwMS and will form the basis of further publications and clinical tools.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Bove, R.University of California, San Francisco, United States (författare)
  • Haddad, L. B.Population Council, Center for Biomedical Research, New York, United States (författare)
  • Hellwig, K.Katholisches Klinikum Bochum gGmbH, Nordrhein-Westfalen, Germany (författare)
  • Houtchens, M.Harvard Medical School and Brigham and Women’s Hospital, Boston, United States (författare)
  • Magyari, M.Danish Multiple Sclerosis Center, Copenhagen, Denmark (författare)
  • Merki-Feld, G. S.Clinic of Reproductive Endocrinology, University Hospital Zürich, Zürich, Switzerland (författare)
  • Montgomery, Scott,1961-Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län(Swepub:oru)smy (författare)
  • Nappi, R. E.Research Center of Reproductive Medicine, IRCCS San Matteo Foundation, Pavia, Italy; University of Pavia, Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, Pavia, Italy (författare)
  • Stenager, E.University of Southern Denmark, Department of Regional Research, Odense, Denmark; MS-clinic of Southern Jutland (Sønderborg, Esbjerg, Kolding), Jutland, Denmark (författare)
  • Thompson, H.Southern Health & Social Care Trust, Portadown, United Kingdom (författare)
  • Tulek, Z.Istanbul University-Cerrahpaşa, Florence Nightingale Faculty of Nursing, Istanbul, Turkey (författare)
  • Di Cantogno, E. VerdunEMD Serono Research & Development Institute (an affiliate of Merck KGaA), Billerica, United States (författare)
  • Simoni, M.University of Modena and Reggio Emilia, Unit of Endocrinology, Department of Medical Specialties, University Hospital and Department of Biomedical, Metabolic and Neural Sciences, Modena, Italy (författare)
  • Karolinska Institutet, Stockholm, SwedenUniversity of California, San Francisco, United States (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Multiple Sclerosis Journal: Sage Publications28:Suppl. 3, s. 187-1881352-45851477-0970

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