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Expert opinion on t...
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Hillert, J.Karolinska Institutet, Stockholm, Sweden
(författare)
Expert opinion on the use of contraception in people with multiple sclerosis
- Artikel/kapitelEngelska2022
Förlag, utgivningsår, omfång ...
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Sage Publications,2022
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:oru-102603
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-102603URI
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Språk:engelska
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Sammanfattning på:engelska
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Klassifikation
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Ämneskategori:vet swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Funding agencies:Merck KGaA, Darmstadt, GermanyMerck Healthcare KGaA, Darmstadt, Germany
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Introduction: The most appropriate use, type, and timing of contraception in people with multiple sclerosis (PwMS) is poorly understood, and specific guidance is absent.Aims and Objectives: To provide insight into potential clinical guidelines for the use of contraception by PwMS through development of recommendations by a consensus-based program led by international clinical experts.Methods: A multidisciplinary steering committee (SC) of 13 international expert healthcare professionals (HCPs) identified 15 key clinical questions on the use of contraception in PwMS, which addressed issues relating to patient-centred care, selection of contraception for PwMS, and time needed to use contraception since the last dose of disease modifying therapies (DMTs). Twenty-five clinical recommendations addressing the questions were drafted using evidence obtained from a comprehensive systematic literature review combined with expert opinion from the SC. An extended faculty of 32 HCPs from 18 countries including a patient association representative, and the SC members (n=12), voted on the recommendations. Consensus on recommendations was achieved when ⩾75% of respondents expressed an agreement score of 7–9, on a 9-point scale.Results: Overall, consensus was achieved on 24 out of 25 clinical recommendations. In detail, consensus in the range of 90–100% was achieved on 11 recommendations, 12 recommendations achieved 80–89% consensus, and 1 recommendation achieved 75–79% consensus (n=44). The strength of recommendations ranged from 7–9. The one statement failing to achieve consensus scored 74.1%. Clinical recommendations are provided on the process of prescribing contraception for PwMS, including the recommended types of HCPs involved and optimal topics to discuss; the range of contraceptive options and the key considerations involved in selecting an appropriate method of contraception; and the timing of starting and stopping contraception in relation to the use of DMTs.Conclusions: These expert recommendations were based on a robust consensus approach, providing timely and practical guidance on the use of contraception for HCPs treating PwMS and will form the basis of further publications and clinical tools.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Bove, R.University of California, San Francisco, United States
(författare)
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Haddad, L. B.Population Council, Center for Biomedical Research, New York, United States
(författare)
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Hellwig, K.Katholisches Klinikum Bochum gGmbH, Nordrhein-Westfalen, Germany
(författare)
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Houtchens, M.Harvard Medical School and Brigham and Women’s Hospital, Boston, United States
(författare)
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Magyari, M.Danish Multiple Sclerosis Center, Copenhagen, Denmark
(författare)
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Merki-Feld, G. S.Clinic of Reproductive Endocrinology, University Hospital Zürich, Zürich, Switzerland
(författare)
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Montgomery, Scott,1961-Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län(Swepub:oru)smy
(författare)
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Nappi, R. E.Research Center of Reproductive Medicine, IRCCS San Matteo Foundation, Pavia, Italy; University of Pavia, Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, Pavia, Italy
(författare)
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Stenager, E.University of Southern Denmark, Department of Regional Research, Odense, Denmark; MS-clinic of Southern Jutland (Sønderborg, Esbjerg, Kolding), Jutland, Denmark
(författare)
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Thompson, H.Southern Health & Social Care Trust, Portadown, United Kingdom
(författare)
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Tulek, Z.Istanbul University-Cerrahpaşa, Florence Nightingale Faculty of Nursing, Istanbul, Turkey
(författare)
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Di Cantogno, E. VerdunEMD Serono Research & Development Institute (an affiliate of Merck KGaA), Billerica, United States
(författare)
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Simoni, M.University of Modena and Reggio Emilia, Unit of Endocrinology, Department of Medical Specialties, University Hospital and Department of Biomedical, Metabolic and Neural Sciences, Modena, Italy
(författare)
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Karolinska Institutet, Stockholm, SwedenUniversity of California, San Francisco, United States
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Multiple Sclerosis Journal: Sage Publications28:Suppl. 3, s. 187-1881352-45851477-0970
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Till lärosätets databas
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Hillert, J.
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Bove, R.
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Haddad, L. B.
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Hellwig, K.
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Houtchens, M.
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Magyari, M.
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visa fler...
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Merki-Feld, G. S ...
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Montgomery, Scot ...
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Nappi, R. E.
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Stenager, E.
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Thompson, H.
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Tulek, Z.
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Di Cantogno, E. ...
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Simoni, M.
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visa färre...
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och Klinisk medicin
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