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Expert opinion on t...
Expert opinion on the use of contraception in people with multiple sclerosis
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- Hillert, J. (author)
- Karolinska Institutet, Stockholm, Sweden
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- Bove, R. (author)
- University of California, San Francisco, United States
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- Haddad, L. B. (author)
- Population Council, Center for Biomedical Research, New York, United States
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- Hellwig, K. (author)
- Katholisches Klinikum Bochum gGmbH, Nordrhein-Westfalen, Germany
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- Houtchens, M. (author)
- Harvard Medical School and Brigham and Women’s Hospital, Boston, United States
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- Magyari, M. (author)
- Danish Multiple Sclerosis Center, Copenhagen, Denmark
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- Merki-Feld, G. S. (author)
- Clinic of Reproductive Endocrinology, University Hospital Zürich, Zürich, Switzerland
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- Montgomery, Scott, 1961- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län
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- Nappi, R. E. (author)
- Research Center of Reproductive Medicine, IRCCS San Matteo Foundation, Pavia, Italy; University of Pavia, Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, Pavia, Italy
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- Stenager, E. (author)
- University of Southern Denmark, Department of Regional Research, Odense, Denmark; MS-clinic of Southern Jutland (Sønderborg, Esbjerg, Kolding), Jutland, Denmark
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- Thompson, H. (author)
- Southern Health & Social Care Trust, Portadown, United Kingdom
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- Tulek, Z. (author)
- Istanbul University-Cerrahpaşa, Florence Nightingale Faculty of Nursing, Istanbul, Turkey
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- Di Cantogno, E. Verdun (author)
- EMD Serono Research & Development Institute (an affiliate of Merck KGaA), Billerica, United States
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- Simoni, M. (author)
- University of Modena and Reggio Emilia, Unit of Endocrinology, Department of Medical Specialties, University Hospital and Department of Biomedical, Metabolic and Neural Sciences, Modena, Italy
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(creator_code:org_t)
- Sage Publications, 2022
- 2022
- English.
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In: Multiple Sclerosis Journal. - : Sage Publications. - 1352-4585 .- 1477-0970. ; 28:Suppl. 3, s. 187-188
- Related links:
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https://urn.kb.se/re...
Abstract
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- Introduction: The most appropriate use, type, and timing of contraception in people with multiple sclerosis (PwMS) is poorly understood, and specific guidance is absent.Aims and Objectives: To provide insight into potential clinical guidelines for the use of contraception by PwMS through development of recommendations by a consensus-based program led by international clinical experts.Methods: A multidisciplinary steering committee (SC) of 13 international expert healthcare professionals (HCPs) identified 15 key clinical questions on the use of contraception in PwMS, which addressed issues relating to patient-centred care, selection of contraception for PwMS, and time needed to use contraception since the last dose of disease modifying therapies (DMTs). Twenty-five clinical recommendations addressing the questions were drafted using evidence obtained from a comprehensive systematic literature review combined with expert opinion from the SC. An extended faculty of 32 HCPs from 18 countries including a patient association representative, and the SC members (n=12), voted on the recommendations. Consensus on recommendations was achieved when ⩾75% of respondents expressed an agreement score of 7–9, on a 9-point scale.Results: Overall, consensus was achieved on 24 out of 25 clinical recommendations. In detail, consensus in the range of 90–100% was achieved on 11 recommendations, 12 recommendations achieved 80–89% consensus, and 1 recommendation achieved 75–79% consensus (n=44). The strength of recommendations ranged from 7–9. The one statement failing to achieve consensus scored 74.1%. Clinical recommendations are provided on the process of prescribing contraception for PwMS, including the recommended types of HCPs involved and optimal topics to discuss; the range of contraceptive options and the key considerations involved in selecting an appropriate method of contraception; and the timing of starting and stopping contraception in relation to the use of DMTs.Conclusions: These expert recommendations were based on a robust consensus approach, providing timely and practical guidance on the use of contraception for HCPs treating PwMS and will form the basis of further publications and clinical tools.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
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- vet (subject category)
- art (subject category)
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- By the author/editor
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Hillert, J.
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Bove, R.
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Haddad, L. B.
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Hellwig, K.
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Houtchens, M.
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Magyari, M.
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Merki-Feld, G. S ...
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Montgomery, Scot ...
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Nappi, R. E.
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Stenager, E.
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Thompson, H.
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Tulek, Z.
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Di Cantogno, E. ...
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Simoni, M.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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Multiple Scleros ...
- By the university
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Örebro University