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Prevalence and micr...
Prevalence and microbiological and genetic characteristics of multidrug-resistant Pseudomonas aeruginosa over three years in Qatar
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- Sid Ahmed, Mazen A. (författare)
- Microbiology Division, Department of Laboratory Medicine and Pathology, Hamad Medical Corporation, Doha, Qatar; School of Science and Technology, Örebro University, Örebro, Sweden,The Life Science Centre - Biology
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- Abdel Hadi, Hamad (författare)
- Department of Infectious Diseases, Communicable Diseases Center, Hamad Medical Corporation, Doha, Qatar
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- Abu Jarir, Sulieman (författare)
- Department of Infectious Diseases, Communicable Diseases Center, Hamad Medical Corporation, Doha, Qatar
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- Khan, Faisal Ahmad, 1986- (författare)
- Örebro universitet,Institutionen för naturvetenskap och teknik,The Life Science Centre - Biology
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- Arbab, Mohammed A. (författare)
- College of Art and Science, Qatar University, Doha, Qatar
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- Hamid, Jemal M. (författare)
- Microbiology Division, Department of Laboratory Medicine and Pathology, Hamad Medical Corporation, Doha, Qatar
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- Alyazidi, Mohammed A. (författare)
- Microbiology Division, Department of Laboratory Medicine and Pathology, Hamad Medical Corporation, Doha, Qatar
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- Al-Maslamani, Muna A. (författare)
- Department of Infectious Diseases, Communicable Diseases Center, Hamad Medical Corporation, Doha, Qatar
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- Skariah, Sini (författare)
- Department of Microbiology and Immunology, Weill Cornell Medicine - Qatar, Doha, Qatar
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- Sultan, Ali A. (författare)
- Department of Microbiology and Immunology, Weill Cornell Medicine - Qatar, Doha, Qatar
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- Al Khal, Abdul Latif (författare)
- Department of Infectious Diseases, Communicable Diseases Center, Hamad Medical Corporation, Doha, Qatar
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- Söderquist, Bo, 1955- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper
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- Ibrahim, Emad Bashir (författare)
- Microbiology Division, Department of Laboratory Medicine and Pathology, Hamad Medical Corporation, Doha, Qatar; Biomedical Research Centre, Qatar University, Doha, Qatar
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- Jass, Jana, 1963- (författare)
- Örebro universitet,Institutionen för naturvetenskap och teknik,The Life Science Centre - Biology
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- Ziglam, Hisham (författare)
- Department of Infectious Diseases, Communicable Diseases Center, Hamad Medical Corporation, Doha, Qatar
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(creator_code:org_t)
- 2022-06-20
- 2022
- Engelska.
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Ingår i: Antimicrobial stewardship & healthcare epidemiology : ASHE. - : Norsk förening for epidemiologi. - 2732-494X .- 2732-494X. ; 2:1
- Relaterad länk:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- OBJECTIVES: Antimicrobial resistance (AMR) is a global priority with significant clinical and economic consequences. Multidrug-resistant (MDR) Pseudomonas aeruginosa is one of the major pathogens associated with significant morbidity and mortality. In healthcare settings, the evaluation of prevalence, microbiological characteristics, as well as mechanisms of resistance is of paramount importance to overcome associated challenges.METHODS: Consecutive clinical specimens of P. aeruginosa were collected prospectively from 5 acute-care and specialized hospitals between October 2014 and September 2017, including microbiological, clinical characteristics and outcomes. Identification and antimicrobial susceptibility test were performed using the BD Phoenix identification and susceptibility testing system, matrix-assisted laser desorption ionization-time-of-flight mass spectrometry (MALDI-TOF MS), and minimum inhibitory concentration (MIC) test strips. Overall, 78 selected MDR P. aeruginosa isolates were processed for whole-genome sequencing (WGS).RESULTS: The overall prevalence of MDR P. aeruginosa isolates was 5.9% (525 of 8,892) and showed a decreasing trend; 95% of cases were hospital acquired and 44.8% were from respiratory samples. MDR P. aeruginosa demonstrated >86% resistance to cefepime, ciprofloxacin, meropenem, and piperacillin-tazobactam but 97.5% susceptibility to colistin. WGS revealed 29 different sequence types: 20.5% ST235, 10.3% ST357, 7.7% ST389, and 7.7% ST1284. ST233 was associated with bloodstream infections and increased 30-day mortality. All ST389 isolates were obtained from patients with cystic fibrosis. Encoded exotoxin genes were detected in 96.2% of isolates.CONCLUSIONS: MDR P. aeruginosa isolated from clinical specimens from Qatar has significant resistance to most agents, with a decreasing trend that should be explored further. Genomic analysis revealed the dominance of 5 main clonal clusters associated with mortality and bloodstream infections. Microbiological and genomic monitoring of MDR P. aeruginosa has enhanced our understanding of AMR in Qatar.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
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Sid Ahmed, Mazen ...
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Abdel Hadi, Hama ...
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Abu Jarir, Sulie ...
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Khan, Faisal Ahm ...
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Arbab, Mohammed ...
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Hamid, Jemal M.
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Alyazidi, Mohamm ...
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Al-Maslamani, Mu ...
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Skariah, Sini
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Sultan, Ali A.
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Al Khal, Abdul L ...
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Söderquist, Bo, ...
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Ibrahim, Emad Ba ...
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Jass, Jana, 1963 ...
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Ziglam, Hisham
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Örebro universitet