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  • Gyldenkerne, ChristineDepartment of Cardiology, Aarhus University Hospital, Aarhus University, Aarhus, Denmark (författare)

Coronary Artery Lesion Lipid Content and Plaque Burden in Diabetic and Nondiabetic Patients : PROSPECT II

  • Artikel/kapitelEngelska2023

Förlag, utgivningsår, omfång ...

  • Lippincott Williams & Wilkins,2023
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:oru-102763
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-102763URI
  • https://doi.org/10.1161/CIRCULATIONAHA.122.061983DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:152025387URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-491186URI
  • https://lup.lub.lu.se/record/f61245c0-a084-4854-a4e6-2f2f6b42b0abURI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding agencies:Abbott LaboratoriesInfraredx Inc, Bedford, MAMedicines Company, Basel, SwitzerlandDanish Diabetes Association
  • BACKGROUND: Patients with diabetes have increased rates of major adverse cardiac events (MACEs). We hypothesized that this is explained by diabetes-associated differences in coronary plaque morphology and lipid content.METHODS: In PROSPECT II (Providing Regional Observations to Study Predictors of Events in the Coronary Tree), 898 patients with acute myocardial infarction with or without ST-segment elevation underwent 3-vessel quantitative coronary angiography and coregistered near-infrared spectroscopy and intravascular ultrasound imaging after successful percutaneous coronary intervention. Subsequent MACEs were adjudicated to either treated culprit lesions or untreated nonculprit lesions. This substudy stratified patients by diabetes status and assessed baseline culprit and nonculprit prevalence of high-risk plaque characteristics defined as maximum plaque burden ≥70% and maximum lipid core burden index ≥324.7. Separate covariate-adjusted multivariable models were performed to identify whether diabetes was associated with nonculprit lesion-related MACEs and high-risk plaque characteristics.RESULTS: Diabetes was present in 109 of 898 patients (12.1%). During a median 3.7-year follow-up, MACEs occurred more frequently in patients with versus without diabetes (20.1% versus 13.5% [odds ratio (OR), 1.94 (95% CI, 1.14-3.30)]), primarily attributable to increased risk of myocardial infarction related to culprit lesion restenosis (4.3% versus 1.1% [OR, 3.78 (95% CI, 1.12-12.77)]) and nonculprit lesion-related spontaneous myocardial infarction (9.3% versus 3.8% [OR, 2.74 (95% CI, 1.25-6.04)]). However, baseline prevalence of high-risk plaque characteristics was similar for patients with versus without diabetes concerning culprit (maximum plaque burden ≥70%: 90% versus 93%, P=0.34; maximum lipid core burden index ≥324.7: 66% versus 70%, P=0.49) and nonculprit lesions (maximum plaque burden ≥70%: 23% versus 22%, P=0.37; maximum lipid core burden index ≥324.7: 26% versus 24%, P=0.47). In multivariable models, diabetes was associated with MACEs in nonculprit lesions (adjusted OR, 2.47 [95% CI, 1.21-5.04]) but not with prevalence of high-risk plaque characteristics (adjusted OR, 1.21 [95% CI, 0.86-1.69]).CONCLUSIONS: Among patients with recent myocardial infarction, both treated and untreated lesions contributed to the diabetes-associated ≈2-fold increased MACE rate during the 3.7-year follow-up. Diabetes-related plaque characteristics that might underlie this increased risk were not identified by multimodality imaging.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Maeng, MichaelDepartment of Cardiology, Aarhus University Hospital, Aarhus University, Aarhus, Denmark (författare)
  • Kjøller-Hansen, LarsDepartment of Cardiology, Zealand University Hospital, Roskilde, Denmark (författare)
  • Maehara, AkikoNew York-Presbyterian Hospital and Division of Cardiology, Columbia University Irving Medical Center, New York, NY, USA; Clinical Trials Center, Cardiovascular Research Foundation, New York, NY, USA (författare)
  • Zhou, ZhipengClinical Trials Center, Cardiovascular Research Foundation, New York, NY, USA (författare)
  • Ben-Yehuda, OriClinical Trials Center, Cardiovascular Research Foundation, New York, NY, USA; Division of Cardiology, University of California, San Diego, USA (författare)
  • Erik Bøtker, HansDepartment of Cardiology, Aarhus University Hospital, Aarhus, Aarhus University, Denmark (författare)
  • Engstrøm, ThomasUniversity of Copenhagen, Copenhagen, Denmark (författare)
  • Matsumura, MitsuakiClinical Trials Center, Cardiovascular Research Foundation, New York, NY, USA (författare)
  • Mintz, Gary S.Clinical Trials Center, Cardiovascular Research Foundation, New York, NY, USA (författare)
  • Fröbert, Ole,1964-Örebro University,Örebro universitet,Institutionen för medicinska vetenskaper,Department of Cardiology, Faculty of Health, Örebro University, Sweden(Swepub:oru)oft (författare)
  • Persson, JonasKarolinska Institutet,Danderyd Hospital (författare)
  • Wiseth, RuneClinic of Cardiology, St Olavs University Hospital, Trondheim, Norway (författare)
  • Larsen, Alf I.Department of Cardiology, Stavanger University Hospital, Stavanger, Norway (författare)
  • Jensen, Lisette O.Department of Cardiology, Odense University Hospital, Odense, Denmark (författare)
  • Nordrehaug, Jan E.Department of Clinical Science, University of Bergen, Bergen, Norway (J.E.N., Ø.B.) (författare)
  • Bleie, ØyvindDepartment of Clinical Science, University of Bergen, Norway (J.E.N., Ø.B.) (författare)
  • Omerovic, ElmirDepartment of Molecular and Clinical Medicine/Cardiology, Sahlgrenska University Hospital, Gothenburg, Sweden (författare)
  • Held, Claes,1956-Uppsala University,Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi,kardiologi(Swepub:uu)clahe947 (författare)
  • James, Stefan K.Uppsala University,Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Institutionen för medicinska vetenskaper(Swepub:uu)stjam367 (författare)
  • Ali, Ziad A.New York-Presbyterian Hospital and Division of Cardiology, Columbia University Irving Medical Center, New York, NY, USA (författare)
  • Rosen, Hans C.Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)ha1345ro (författare)
  • Stone, Gregg W.The Zena and Michael A Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA (författare)
  • Erlinge, DavidLund University,Lunds universitet,Molekylär kardiologi,Forskargrupper vid Lunds universitet,Molecular Cardiology,Lund University Research Groups(Swepub:lu)kard-der (författare)
  • Bleie, O (författare)
  • Department of Cardiology, Aarhus University Hospital, Aarhus University, Aarhus, DenmarkDepartment of Cardiology, Zealand University Hospital, Roskilde, Denmark (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Circulation: Lippincott Williams & Wilkins147:6, s. 469-4810009-73221524-4539

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