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Longterm visual pro...
Longterm visual prognosis in Usher syndrome types 1 and 2
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- Sadeghi, André M. (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för arbetsterapi, audiologi och fysioterapi,Institute of Neuroscience and Physiology, Department of Audiology, Logopedics, Occupational Therapy & Physiotherapy
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Eriksson, Kristina, 1962 (author)
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Kimberling, William J. (author)
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- Sjöström, Anders, 1951 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences
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- Möller, Claes, 1950- (author)
- Gothenburg University,Göteborgs universitet,Örebro universitet,Institutionen för klinisk medicin,Institutionen för neurovetenskap och fysiologi, sektionen för arbetsterapi, audiologi och fysioterapi,Institute of Neuroscience and Physiology, Department of Audiology, Logopedics, Occupational Therapy & Physiotherapy
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(creator_code:org_t)
- 2006-05-30
- 2006
- English.
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In: Acta Ophthalmologica Scandinavica. - Copenhagen : Blackwell Munksgaard. - 1395-3907 .- 1600-0420. ; 84:4, s. 537-544
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Abstract
Subject headings
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- Purpose: To estimate the age at diagnosis of retinitis pigmentosa and to determine visual acuity deterioration, visual field impairment and the frequency of cataracts in Usher syndrome types 1 and 2. Methods: We carried out a retrospective study of 328 affected subjects with Usher syndrome types 1 and 2. Study subjects were divided into seven different age groups by decade. Data were analysed using descriptive statistics, general linear model anova and survival analysis. Results: Retinitis pigmentosa was diagnosed significantly earlier in subjects with Usher syndrome type 1 than in those with type 2. Visual acuity was significantly more impaired in affected subjects with Usher syndrome type 1 than in those with type 2 from 50 years of age onwards. Survival analysis revealed a significant difference in visual field loss (≤ 10 degrees) between the two groups, with type 2 subjects tending to be more impaired, while comparison indicated no significant differences between the groups in any of the other visual field categories. Cataract was found to be generally more common in Usher syndrome type 1 than type 2. Conclusions: Progressive loss of visual acuity and visual field begins to be substantial between the second and third decades of life in both Usher types. The rate of degeneration varies between individuals in both groups. The data are useful for the counselling of affected subjects with Usher syndrome types 1 and 2.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Oftalmologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Ophthalmology (hsv//eng)
Keyword
- MEDICINE
- MEDICIN
- Medicine
- medicin
- Usher syndrome; retinitis pigmentosa; visual acuity loss; visual field loss; cataract
Publication and Content Type
- ref (subject category)
- art (subject category)
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