Visual evoked potentials after hematopoietic allogeneic stem cell transplantation in childhood

• OBJECTIVE: To study visual pathway pathology detected by visual evoked potentials (VEPs) in patients treated with hematopoietic stem cell transplantation (HSCT) in childhood and to determine the impact of adverse ocular findings, somatic diseases, and conditioning regimens on the VEP results.METHODS: Ophthalmological assessments including pattern VEPs were performed in 47 of 79 patients at a median age of 15 years (range 3-21 years) in median 6 years (1-17 years) after HSCT. Somatic data were extracted from medical records.RESULTS: Eight patients of 47 (17%) demonstrated pathological VEPs with prolonged latencies bilaterally (n = 3) or unilaterally (n = 5) at their latest VEP test at an age of 12-18 years. A subnormal visual acuity was present in 8/11 eyes with pathological VEPs: one eye had cataract, six eyes had cataract surgery where of two had developed secondary cataracts. One eye had residual retinopathy of prematurity. Pathological VEPs were associated with decreased visual acuity (p = 0.00019) but not linked to gender, malignant diagnosis or conditioning.CONCLUSION: VEP recordings showed an association with decreased visual acuity but no relationship with irradiation or chemotherapy in the present study.SIGNIFICANCE: VEP recordings might be of clinical value for children with an unexplained subnormal visual acuity undergoing HSCT.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Oftalmologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Ophthalmology (hsv//eng)

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)

Nyckelord

BCVA

best corrected visual acuity

CI

cranial irradiation

CNS

central nervous system

CT

computerized tomography

CyA

cyclosporine A

GVHD

graft versus host disease

HLA

human leukocyte antigen

HSCT

hematopoietic stem cell transplantation

Hematopoietic stem cell transplantation

IOL

intra ocular lens

MRI

magnetic resonance imaging

ROP

retinopathy of prematurity

TBI

total body irradiation

VEP

visual evoked potentials

Visual acuity

Visual evoked potentials

f-TBI

fractionated total body irradiation

s-TBI

single fractio total body irradiation

Hematopoietic stem cell transplantation

Visual acuity

Visual evoked potentials

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)