Various Aspects of Gastrointestinal Disease: Examining Validity and Health Economic Outcomes

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Bozorg, Soran Rabin,1993-Örebro universitet,Institutionen för medicinska vetenskaper (författare)

Various Aspects of Gastrointestinal Disease : Examining Validity and Health Economic Outcomes

BokEngelska2022

Förlag, utgivningsår, omfång ...

Örebro :Örebro universitet,2022
49 s.
electronicrdacarrier

Nummerbeteckningar

LIBRIS-ID:oai:DiVA.org:oru-104059
ISBN:9789175294520
https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-104059URI

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Språk:engelska
Sammanfattning på:engelska

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Ämneskategori:vet swepub-contenttype
Ämneskategori:lic swepub-publicationtype

Serie

Örebro Studies in Medicine,1652-4063

Anmärkningar

Introduction: Recent years have seen significant research advances within the gastroenterological field. Some of these consist of the recognition of serrated polyps as a precursor to colorectal cancer, and the realization of the health economic burden associated with gastrointestinal diseases.Aim: In this thesis, we aim to validate the specificity of serrated polyps in the ESPRESSO cohort (Paper I). We also aim to estimate work loss in patients with celiac disease, including the temporal relationship of work loss before and after diagnosis (Paper II).Method: By using the ESPRESSO cohort, we collected data on patients with serrated polyps and patients with celiac disease. In Paper I, the specificity of serrated polyps in the ESPRESSO cohort were validated by a structured retrospective review of patient chart. In Paper II, we estimated work loss in patients with celiac disease as compared withgeneral-population comparators matched on age, sex, county of residence and year of diagnosis.Result: The presence of a serrated polyp was confirmed in 101 out of 106 individuals identified through the ESPRESSO cohort, yielding a positive predictive value of 95% (95% confidence interval: 89-98%). Patients with celiac disase had 42.5 lost work days as compared to 28.6 days in comparators (mean difference, 14.7; 95% confidence interval, 13.2-16.2), corresponding to a relative increase of 49%. Excess work loss in patients with celiac disease was observed even 5 years before diagnosis and remained eleveated during the years after diagnosis this loss. Notebly, the excess work loss was concentrated to a small proportion while most celiac patients did not have any work loss before or after diagnosis. Conclusion: The ESPRESSO cohort has a high specificity for serrated polyps. Patients with celiac disease miss more work days than the general population even before diagnosis, and this loss persists after diagnosis.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Allmänmedicin hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine General Practice hsv//eng
Serrated polyp
sessile serrated lesion
validation
celiac disease
sick leave
cost
economic burden
health economics

Biuppslag (personer, institutioner, konferenser, titlar ...)

Ludvigsson, Jonas F.,professor,1969-Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län(Swepub:oru)jsln (preses)
Mårild, Karl,1982- (preses)
Everhov Hallqvist, ÅsaKarolinska Institutet, Stockholm, Sweden (preses)
Söderling, JonasKarolinska Institutet, Stockholm, Sweden (preses)
Örebro universitetInstitutionen för medicinska vetenskaper (creator_code:org_t)

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Av författaren/redakt...: Bozorg, Soran Ra ...; Ludvigsson, Jona ...; Mårild, Karl, 19 ...; Everhov Hallqvis ...; Söderling, Jonas

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Av lärosätet: Örebro universitet

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