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Association of infl...
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Wang, KaiDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA
(författare)
Association of inflammatory bowel disease in first-degree relatives with risk of colorectal cancer : A nationwide case-control study in Sweden
- Artikel/kapitelEngelska2023
Förlag, utgivningsår, omfång ...
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2023-02-20
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John Wiley & Sons,2023
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:oru-104139
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-104139URI
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https://doi.org/10.1002/ijc.34470DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:152000826URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Funding agencies:United States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA R00 CA215314 U01 CA261961 R01 CA263776American Cancer Society MRSG-17-220-01-NECALF 20190638
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This study aims to assess the association between inflammatory bowel disease (IBD) history in first-degree relatives (FDRs) and colorectal cancer (CRC) risk. We conducted a nationwide case-control study in Sweden among 69,659 CRC cases and 343,032 non-CRC controls matched on age, sex, birth year, and residence county. Through linkage of multi-generation register and the nationwide ESPRESSO (Epidemiology Strengthened by histoPathology Reports in Sweden) cohort, we ascertained IBD diagnoses among parents, full siblings, and offspring of the index individuals. Odds ratios (ORs) of CRC associated with IBD family history were calculated using conditional logistic regression. 2.2% of both CRC cases (1,566/69,659) and controls (7,676/343,027) had ≥1 FDR with IBD history. After adjusting for family history of CRC, we observed no increased risk of CRC in FDRs of IBD patients (OR, 0.96; 95%CI, 0.91-1.02). The null association was consistent according to IBD subtype (Crohn's disease or ulcerative colitis), number of FDRs with IBD (1 or ≥2), age at first IBD diagnosis in FDRs (<18, 18-39, 40-59, or ≥60 years), maximum location/extent of IBD, or FDR relation (parent, sibling, or offspring). The null association remained for early-onset CRC (diagnosed at age <50 years). In conclusion, IBD history in FDRs was not associated with an increased risk of CRC. Our findings suggest that extra screening for CRC may not be needed in the offspring, siblings, or parents of IBD patients, and strengthen the theory that it is the actual inflammation or atypia of the colon in IBD patients that confers the increased CRC risk.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Olén, OlaKarolinska Institutet
(författare)
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Emilsson, LouiseKarolinska Institutet
(författare)
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Khalili, HamedClinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, MA, USA; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Institute of Environmental Medicine, Nutrition Epidemiology, Karolinska Institutet, Solna, Sweden
(författare)
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Halfvarson, Jonas,1970-Örebro universitet,Institutionen för medicinska vetenskaper,Department of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden(Swepub:oru)jshn
(författare)
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Song, MingyangDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, MA, USA; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA
(författare)
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Ludvigsson, Jonas F.,1969-Karolinska Institutet(Swepub:oru)jsln
(författare)
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Karolinska InstitutetDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:International Journal of Cancer: John Wiley & Sons152:11, s. 2303-23130020-71361097-0215
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