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  • Brodin, DanielDepartment of Medicine, Capio S:t Göran's Hospital, Stockholm, Sweden,Capio St Gorans Hosp, Dept Med, Stockholm, Sweden. (författare)

Inhaled ciclesonide in adults hospitalised with COVID-19 : a randomised controlled open-label trial (HALT COVID-19)

  • Artikel/kapitelEngelska2023

Förlag, utgivningsår, omfång ...

  • 2023-02-22
  • BMJ Publishing Group Ltd,2023
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:oru-104438
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-104438URI
  • https://doi.org/10.1136/bmjopen-2022-064374DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-501168URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:236813503URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:152401460URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:155253745URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • OBJECTIVE: To assess the efficacy of inhaled ciclesonide in reducing the duration of oxygen therapy (an indicator of time to clinical improvement) among adults hospitalised with COVID-19.DESIGN: Multicentre, randomised, controlled, open-label trial.SETTING: 9 hospitals (3 academic hospitals and 6 non-academic hospitals) in Sweden between 1 June 2020 and 17 May 2021.PARTICIPANTS: Adults hospitalised with COVID-19 and receiving oxygen therapy.INTERVENTION: Inhaled ciclesonide 320 µg two times a day for 14 days versus standard care.MAIN OUTCOME MEASURES: Primary outcome was duration of oxygen therapy, an indicator of time to clinical improvement. Key secondary outcome was a composite of invasive mechanical ventilation/death.RESULTS: Data from 98 participants were analysed (48 receiving ciclesonide and 50 receiving standard care; median (IQR) age, 59.5 (49-67) years; 67 (68%) men). Median (IQR) duration of oxygen therapy was 5.5 (3-9) days in the ciclesonide group and 4 (2-7) days in the standard care group (HR for termination of oxygen therapy 0.73 (95% CI 0.47 to 1.11), with the upper 95% CI being compatible with a 10% relative reduction in oxygen therapy duration, corresponding to a <1 day absolute reduction in a post-hoc calculation). Three participants in each group died/received invasive mechanical ventilation (HR 0.90 (95% CI 0.15 to 5.32)). The trial was discontinued early due to slow enrolment.CONCLUSIONS: In patients hospitalised with COVID-19 receiving oxygen therapy, this trial ruled out, with 0.95 confidence, a treatment effect of ciclesonide corresponding to more than a 1 day reduction in duration of oxygen therapy. Ciclesonide is unlikely to improve this outcome meaningfully.TRIAL REGISTRATION NUMBER: NCT04381364.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Tornhammar, PerFunctional Area of Emergency Medicine, Karolinska Institute, Stockholm, Sweden,Karolinska Inst, Funct Area Emergency Med, Stockholm, Sweden. (författare)
  • Ueda, PeterKarolinska Institutet (författare)
  • Krifors, AndersUppsala universitet,Centrum för klinisk forskning, Västerås,Karolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden.;Uppsala Univ, Ctr Clin Res Vastmanland, Uppsala, Sweden. (författare)
  • Westerlund, EliKarolinska Institutet (författare)
  • Athlin, Simon,1971-Örebro universitet,Institutionen för medicinska vetenskaper,Örebro Univ, Sch Med Sci, Örebro, Sweden.(Swepub:oru)soan (författare)
  • Wojt, SandraDepartment of Internal Medicine, Danderyd Hospital, Stockholm, Sweden,Danderyd Hosp, Dept Internal Med, Stockholm, Sweden. (författare)
  • Elvstam, OlofDepartment of Infectious Diseases, Central Hospital Växjö, Vaxjö, Sweden,Cent Hosp Växjö, Dept Infect Dis, Växjö, Sweden. (författare)
  • Neumann, AncaDepartment of Medicine, Capio S:t Göran's Hospital, Stockholm, Sweden,Capio St Gorans Hosp, Dept Med, Stockholm, Sweden. (författare)
  • Elshani, ArsimDepartment of Medicine and Geriatrics, Karlskoga Hospital, Karlskoga, Sweden,Karlskoga Hosp, Dept Med & Geriatr, Karlskoga, Sweden. (författare)
  • Giesecke, JuliaFunctional Area of Emergency Medicine, Karolinska Institute, Stockholm, Sweden,Karolinska Inst, Funct Area Emergency Med, Stockholm, Sweden. (författare)
  • Edvardsson-Källkvist, JensKarolinska University Hospital, Stockholm, Sweden,Karolinska Univ Hosp, Stockholm, Sweden. (författare)
  • Bunpuckdee, SayamFunctional Area of Emergency Medicine, Karolinska Institute, Stockholm, Sweden,Karolinska Inst, Funct Area Emergency Med, Stockholm, Sweden. (författare)
  • Unge, ChristianDepartment of Internal Medicine, Danderyd Hospital, Stockholm, Sweden,Danderyd Hosp, Dept Internal Med, Stockholm, Sweden. (författare)
  • Larsson, MartinDepartment of Endocrinology, Karolinska University Hospital, Stockholm, Sweden; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden,Karolinska Univ Hosp, Dept Endocrinol, Stockholm, Sweden.;Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden. (författare)
  • Johansson, BjörnDepartment of Infectious Diseases, Halland's Hospital Halmstad, Halmstad, Sweden,Hallands Hosp Halmstad, Dept Infect Dis, Halmstad, Sweden. (författare)
  • Ljungberg, JohanDepartment of Infectious Diseases, Halland's Hospital Halmstad, Halmstad, Sweden,Hallands Hosp Halmstad, Dept Infect Dis, Halmstad, Sweden. (författare)
  • Lindell, JonasDepartment of Infectious Diseases, Visby Hospital, Visby, Sweden,Visby Hosp, Dept Infect Dis, Visby, Sweden. (författare)
  • Hansson, JohanDepartment of Infectious Diseases, Östersund Hospital, Östersund, Sweden,Östersund Hosp, Dept Infect Dis, Östersund, Sweden. (författare)
  • Blennow, OlaDepartment of Medicine, Capio S:t Göran's Hospital, Stockholm, Sweden; Department of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden,Capio St Gorans Hosp, Dept Med, Stockholm, Sweden.;Karolinska Univ Hosp, Dept Infect Dis, Stockholm, Sweden. (författare)
  • Andersson, Daniel PeterKarolinska Institutet (författare)
  • Department of Medicine, Capio S:t Göran's Hospital, Stockholm, SwedenCapio St Gorans Hosp, Dept Med, Stockholm, Sweden. (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:BMJ Open: BMJ Publishing Group Ltd13:22044-6055

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  • BMJ Open (Sök värdpublikationen i LIBRIS)

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