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CBL/CAP Is Essentia...
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Aye, Cho-ChoThe Department of Cellular and Molecular Physiology, Institute of Translational Medicine, The University of Liverpool, Crown Street, Liverpool L69 3BX, UK
(författare)
CBL/CAP Is Essential for Mitochondria Respiration Complex I Assembly and Bioenergetics Efficiency in Muscle Cells
- Artikel/kapitelEngelska2023
Förlag, utgivningsår, omfång ...
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2023-02-08
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MDPI,2023
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:oru-104529
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-104529URI
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https://doi.org/10.3390/ijms24043399DOI
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Språk:engelska
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Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Funding agencies:University of LiverpoolEuropean Commission Joint Research Centre HEALTH-F4-2008-223450United States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA GM105781Instituto de Salud Carlos III-MINECO/European FEDER Funds PI17-00048Scottish Funding Council and Highlands and Islands Enterprise
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CBL is rapidly phosphorylated upon insulin receptor activation. Mice whole body CBL depletion improved insulin sensitivity and glucose clearance; however, the precise mechanisms remain unknown. We depleted either CBL or its associated protein SORBS1/CAP independently in myocytes and assessed mitochondrial function and metabolism compared to control cells. CBL- and CAP-depleted cells showed increased mitochondrial mass with greater proton leak. Mitochondrial respiratory complex I activity and assembly into respirasomes were reduced. Proteome profiling revealed alterations in proteins involved in glycolysis and fatty acid degradation. Our findings demonstrate CBL/CAP pathway couples insulin signaling to efficient mitochondrial respiratory function and metabolism in muscle.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Hammond, Dean E.The Department of Cellular and Molecular Physiology, Institute of Translational Medicine, The University of Liverpool, Crown Street, Liverpool L69 3BX, UK
(författare)
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Rodriguez-Cuenca, SergioMetabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, University of Cambridge, Cambridge CB2 0QQ, UK
(författare)
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Doherty, Mary K.Division of Biomedical Sciences, Centre for Health Science, University of the Highlands and Islands, Old Perth Road, Inverness IV2 3JH, UK
(författare)
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Whitfield, Phillip D.Division of Biomedical Sciences, Centre for Health Science, University of the Highlands and Islands, Old Perth Road, Inverness IV2 3JH, UK; Glasgow Polyomics, College of Medical, Veterinary and Life Sciences, Garscube Campus, University of Glasgow, Glasgow G61 1BD, UK
(författare)
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Phelan, Marie M.Centre for Nuclear Magnetic Resonance, Institute of Integrative Biology, University of Liverpool, Crown Street, Liverpool L69 3BX, UK
(författare)
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Yang, ChenjingThe Department of Cellular and Molecular Physiology, Institute of Translational Medicine, The University of Liverpool, Crown Street, Liverpool L69 3BX, UK
(författare)
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Perez-Perez, RafaelInstituto de Investigación, Hospital Universitario 12 de Octubre, Avda. de Córdoba s/n, 28041 Madrid, Spain; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), U723, 28029 Madrid, Spain
(författare)
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Li, XiaoxinThe Department of Cellular and Molecular Physiology, Institute of Translational Medicine, The University of Liverpool, Crown Street, Liverpool L69 3BX, UK
(författare)
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Diaz-Ramos, AngelsInstitute for Research in Biomedicine, C/Baldiri Reixac 10, 08028 Barcelona, Spain
(författare)
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Peddinti, GopalTechnical Research Centre of Finland, 02044 Espoo, Finland
(författare)
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Oresic, Matej,1967-Örebro universitet,Institutionen för medicinska vetenskaper,Technical Research Centre of Finland, 02044 Espoo, Finland; Turku Centre for Biotechnology, University of Turku and Abo Akademi University, 20520 Turku, Finland(Swepub:oru)moc
(författare)
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Vidal-Puig, AntonioMetabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, University of Cambridge, Cambridge CB2 0QQ, UK; Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK
(författare)
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Zorzano, AntonioInstitute for Research in Biomedicine, C/Baldiri Reixac 10, 08028 Barcelona, Spain; CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, 28029 Madrid, Spain; Department de Bioquimica i Biomedicina, Facultat de Biologia, Universitat de Barcelona, 08028 Barcelona, Spain
(författare)
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Ugalde, CristinaInstituto de Investigación, Hospital Universitario 12 de Octubre, Avda. de Córdoba s/n, 28041 Madrid, Spain; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), U723, 28029 Madrid, Spain
(författare)
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Mora, SilviaThe Department of Cellular and Molecular Physiology, Institute of Translational Medicine, The University of Liverpool, Crown Street, Liverpool L69 3BX, UK; Department de Bioquimica i Biomedicina, Facultat de Biologia, Universitat de Barcelona, 08028 Barcelona, Spain; Institut de Biomedicina de la Universitat de Barcelona (IBUB), Universitat de Barcelona, 08028 Barcelona, Spain
(författare)
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The Department of Cellular and Molecular Physiology, Institute of Translational Medicine, The University of Liverpool, Crown Street, Liverpool L69 3BX, UKMetabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, University of Cambridge, Cambridge CB2 0QQ, UK
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:International Journal of Molecular Sciences: MDPI24:41661-65961422-0067
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Till lärosätets databas
- Av författaren/redakt...
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Aye, Cho-Cho
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Hammond, Dean E.
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Rodriguez-Cuenca ...
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Doherty, Mary K.
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Whitfield, Phill ...
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Phelan, Marie M.
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visa fler...
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Yang, Chenjing
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Perez-Perez, Raf ...
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Li, Xiaoxin
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Diaz-Ramos, Ange ...
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Peddinti, Gopal
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Oresic, Matej, 1 ...
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Vidal-Puig, Anto ...
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Zorzano, Antonio
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Ugalde, Cristina
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Mora, Silvia
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Örebro universitet