Search: WFRF:(Ställberg Björn Docent) >
Factors Associated ...
Factors Associated with the Non-Exacerbator Phenotype of Chronic Obstructive Pulmonary Disease
-
- Bouhuis, Dennis (author)
- School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden,Örebro Univ, Fac Med & Hlth, Sch Med Sci, Örebro, Sweden.
-
- Giezeman, Maaike, 1969- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Centre for Clinical Research and Education, Karlstad, Sweden,Örebro Univ, Fac Med & Hlth, Sch Med Sci, Örebro, Sweden.;Ctr Clin Res & Educ, Karlstad, Sweden.
-
- Hasselgren, Mikael, 1964- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Centre for Clinical Research and Education, Karlstad, Sweden,Örebro Univ, Fac Med & Hlth, Sch Med Sci, Örebro, Sweden.;Ctr Clin Res & Educ, Karlstad, Sweden.
-
show more...
-
- Janson, Christer (author)
- Uppsala universitet,Lung- allergi- och sömnforskning
-
- Kisiel, Marta, 1984- (author)
- Uppsala universitet,Arbets- och miljömedicin
-
- Lisspers, Karin, Docent, 1954- (author)
- Uppsala universitet,Allmänmedicin och preventivmedicin
-
- Montgomery, Scott, 1961- (author)
- Karolinska Institutet,Örebro universitet,Institutionen för medicinska vetenskaper,Clinical Epidemiology and Biostatistics, School of Medical Sciences, Faculty of Medicine and Health, Örebro, Sweden; Clinical Epidemiology Division, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden; Department of Epidemiology and Public Health, University College, London, UK,Fac Med & Hlth, Sch Med Sci, Clin Epidemiol & Biostat, Örebro, Sweden.;Karolinska Inst, Dept Med, Clin Epidemiol Div, Stockholm, Sweden.;UCL, Dept Epidemiol & Publ Hlth, London, England.
-
- Nager, Anna (author)
- Department of Neurobiology, Care Sciences and Society, Division of Family Medicine and Primary Care, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Family Med & Primary Care, Stockholm, Sweden.
-
- Sandelowsky, Hanna (author)
- Karolinska Institutet
-
- Ställberg, Björn, Docent (author)
- Uppsala universitet,Allmänmedicin och preventivmedicin
-
- Sundh, Josefin, 1972- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Respiratory Medicine,Örebro Univ, Fac Med & Hlth, Dept Resp Med, Örebro, Sweden.
-
show less...
-
School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden Örebro Univ, Fac Med & Hlth, Sch Med Sci, Örebro, Sweden (creator_code:org_t)
- Dove Medical Press Ltd. 2023
- 2023
- English.
-
In: The International Journal of Chronic Obstructive Pulmonary Disease. - : Dove Medical Press Ltd.. - 1176-9106 .- 1178-2005. ; 18, s. 483-492
- Related links:
-
https://doi.org/10.2...
-
show more...
-
https://uu.diva-port... (primary) (Raw object)
-
https://urn.kb.se/re...
-
https://doi.org/10.2...
-
https://urn.kb.se/re...
-
http://kipublication...
-
show less...
Abstract
Subject headings
Close
- BACKGROUND: Patients with chronic obstructive pulmonary disease (COPD) and no exacerbations may need less maintenance treatment and follow-up. The aim was to identify factors associated with a non-exacerbator COPD phenotype.METHODS: Cross-sectional analysis of 1354 patients from primary and secondary care, with a doctor's diagnosis of COPD. In 2014, data on demographics, exacerbation frequency and symptoms using COPD Assessment Test (CAT) were collected using questionnaires and on spirometry and comorbid conditions by record review. The non-exacerbator phenotype was defined as having reported no exacerbations the previous six months. Multivariable logistic regression with the non-exacerbator phenotype as dependent variable was performed, including stratification and interaction analyses by sex.RESULTS: The non-exacerbator phenotype was found in 891 (66%) patients and was independently associated with COPD stage 1 (OR [95% CI] 5.72 [3.30-9.92]), stage 2 (3.42 [2.13-5.51]) and stage 3 (2.38 [1.46-3.88]) compared with stage 4, and with CAT score <10 (3.35 [2.34-4.80]). Chronic bronchitis and underweight were inversely associated with the non-exacerbator phenotype (0.47 [0.28-0.79]) and (0.68 [0.48-0.97]), respectively. The proportion of non-exacerbators was higher among patients with no maintenance treatment or a single bronchodilator. The association of COPD stage 1 compared with stage 4 with the non-exacerbator phenotype was stronger in men (p for interaction 0.048). In women, underweight and obesity were both inversely associated with the non-exacerbator phenotype (p for interaction 0.033 and 0.046 respectively), and in men heart failure was inversely associated with the non-exacerbator phenotype (p for interaction 0.030).CONCLUSION: The non-exacerbator phenotype is common, especially in patients with no maintenance treatment or a single bronchodilator, and is characterized by preserved lung function, low symptom burden, and by absence of chronic bronchitis, underweight and obesity and heart failure. We suggest these patients may need less treatment and follow-up, but that management of comorbid conditions is important to avoid exacerbations.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Keyword
- CAT
- COPD
- body mass index
- chronic bronchitis
- exacerbations
- heart failure
- lung function
- sex
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Bouhuis, Dennis
-
Giezeman, Maaike ...
-
Hasselgren, Mika ...
-
Janson, Christer
-
Kisiel, Marta, 1 ...
-
Lisspers, Karin, ...
-
show more...
-
Montgomery, Scot ...
-
Nager, Anna
-
Sandelowsky, Han ...
-
Ställberg, Björn ...
-
Sundh, Josefin, ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Respiratory Medi ...
- Articles in the publication
-
The Internationa ...
- By the university
-
Örebro University
-
Uppsala University
-
Karolinska Institutet