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  • Thienel, ManuelaDepartment of Cardiology, University Hospital, LMU Munich, 81377 Munich, Germany; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, 80802 Munich, Germany (författare)

Immobility-associated thromboprotection is conserved across mammalian species from bear to human

  • Artikel/kapitelEngelska2023

Förlag, utgivningsår, omfång ...

  • American Association for the Advancement of Science (AAAS),2023
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:oru-105529
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-105529URI
  • https://doi.org/10.1126/science.abo5044DOI
  • https://res.slu.se/id/publ/121998URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding agencies:German Research Foundation (DFG) PE2704/2-1 PE2704/3-1DZHK (German Center for Cardiovascular Research) 80JSC018P0078 80JSC019P0010 100378833 806 32 006LMU Munich's Clinician scientist program in vascular medicine (PRIME)LMU Munich's institutional Forderprogramm fur Forschung und Lehre (FuFoLe)European Research Council (ERC) IFF 2020-26Helmholtz AssociationGerman Aerospace Centre (DLR)National Aeronautics & Space Administration (NASA)Faculty of Health at Witten/Herdecke University, GermanyBritish Heart Foundation FS/17/31/32848 SFB 1123Norwegian Environment Agency TRR267LMU Munich's Institutional Strategy LMU excellent
  • Venous thromboembolism (VTE) comprising deep venous thrombosis and pulmonary embolism is a major cause of morbidity and mortality. Short-term immobility-related conditions are a major risk factor for the development of VTE. Paradoxically, long-term immobilized free-ranging hibernating brown bears and paralyzed spinal cord injury (SCI) patients are protected from VTE. We aimed to identify mechanisms of immobility-associated VTE protection in a cross-species approach. Mass spectrometry-based proteomics revealed an antithrombotic signature in platelets of hibernating brown bears with heat shock protein 47 (HSP47) as the most substantially reduced protein. HSP47 down-regulation or ablation attenuated immune cell activation and neutrophil extracellular trap formation, contributing to thromboprotection in bears, SCI patients, and mice. This cross-species conserved platelet signature may give rise to antithrombotic therapeutics and prognostic markers beyond immobility-associated VTE.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Müller-Reif, Johannes B.Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany; Omicera Diagnostics, 82152 Martinsried, Germany (författare)
  • Zhang, ZheDepartment of Cardiology, University Hospital, LMU Munich, 81377 Munich, Germany (författare)
  • Ehreiser, VincentDepartment of Cardiology, University Hospital, LMU Munich, 81377 Munich, Germany; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, 80802 Munich, Germany (författare)
  • Huth, JudithDepartment of Cardiology, University Hospital, LMU Munich, 81377 Munich, Germany; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, 80802 Munich, Germany (författare)
  • Shchurovska, KhrystynaDepartment of Cardiology, University Hospital, LMU Munich, 81377 Munich, Germany; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, 80802 Munich, Germany (författare)
  • Kilani, BadrDepartment of Cardiology, University Hospital, LMU Munich, 81377 Munich, Germany; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, 80802 Munich, Germany (författare)
  • Schweizer, LisaDepartment of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany (författare)
  • Geyer, Philipp E.Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany; Omicera Diagnostics, 82152 Martinsried, Germany (författare)
  • Zwiebel, MaximilianDepartment of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany (författare)
  • Novotny, JuliaDepartment of Cardiology, University Hospital, LMU Munich, 81377 Munich, Germany (författare)
  • Lüsebrink, EnzoDepartment of Cardiology, University Hospital, LMU Munich, 81377 Munich, Germany (författare)
  • Little, GemmaInstitute for Cardiovascular and Metabolic Research, School of Biological Sciences, Health and Life Sciences Building, University of Reading, RG6 6UR, UK (författare)
  • Orban, MartinDepartment of Cardiology, University Hospital, LMU Munich, 81377 Munich, Germany (författare)
  • Nicolai, LeoDepartment of Cardiology, University Hospital, LMU Munich, 81377 Munich, Germany; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, 80802 Munich, Germany (författare)
  • El Nemr, ShazaDepartment of Cardiology, University Hospital, LMU Munich, 81377 Munich, Germany; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, 80802 Munich, Germany (författare)
  • Titova, AnnaDepartment of Cardiology, University Hospital, LMU Munich, 81377 Munich, Germany; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, 80802 Munich, Germany (författare)
  • Spannagl, MichaelAnesthesiology and Transfusion Medicine, Cell Therapeutics and Hemostaseology, Ludwig-Maximilians-University Munich, 80336 Munich, Germany (författare)
  • Kindberg, JonasSwedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för vilt, fisk och miljö,Department of Wildlife, Fish and Environmental Studies,Norwegian Institute Nature Research(Swepub:slu)48411 (författare)
  • Evans, Alina L.Department of Forestry and Wildlife Management, Faculty of Applied Ecology and Agricultural Sciences, Inland Norway University of Applied Sciences, 2480 Koppang, Norway (författare)
  • Mach, OrpheusZentrum für Rückenmarkverletzte mit Neuro-Urologie, BG Unfallklinik Murnau, 82418 Murnau am Staffelsee, Germany (författare)
  • Vogel, MatthiasZentrum für Rückenmarkverletzte mit Neuro-Urologie, BG Unfallklinik Murnau, 82418 Murnau am Staffelsee, Germany (författare)
  • Tiedt, SteffenNeurologische Klinik und Poliklinik, Klinikum der Universität München, Ludwig-Maximilians- University Munich, 81377 Munich, Germany (författare)
  • Ormanns, SteffenPathologisches Institut, Klinikum der Universität München, Ludwig-Maximilians- University Munich, 81377 Munich, Germany (författare)
  • Kessler, BarbaraGene Center, Ludwig-Maximilians-University Munich, 81377 Munich, Germany (författare)
  • Dueck, AnneDZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, 80802 Munich, Germany; Institute of Pharmacology and Toxicology, Technical University of Munich, 80802 Munich, Germany (författare)
  • Friebe, AndreaNorwegian Institute for Nature Research, 7034 Trondheim, Norway; Scandinavian Brown Bear Research Project, Tackåsen 2, SE-79498 Orsa, Sweden (författare)
  • Jørgensen, Peter GodskHerlev and Gentofte University Hospital, Borgmester Ib Juuls Vej 1, DK-2730, Herlev, Copenhagen, Denmark (författare)
  • Majzoub-Altweck, MonirInstitute of Veterinary Pathology, Center for Clinical Veterinary Medicine, LMU Munich, 80539 Munich, Germany (författare)
  • Blutke, AndreasInstitute of Veterinary Pathology, Center for Clinical Veterinary Medicine, LMU Munich, 80539 Munich, Germany (författare)
  • Polzin, AminDivision of Cardiology, Pulmonology, and Vascular Medicine, Heinrich Heine University Medical Center Dusseldorf, 40225 Dusseldorf, Germany (författare)
  • Stark, KonstantinDepartment of Cardiology, University Hospital, LMU Munich, 81377 Munich, Germany; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, 80802 Munich, Germany (författare)
  • Kääb, StefanDepartment of Cardiology, University Hospital, LMU Munich, 81377 Munich, Germany; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, 80802 Munich, Germany (författare)
  • Maier, DorisZentrum für Rückenmarkverletzte mit Neuro-Urologie, BG Unfallklinik Murnau, 82418 Murnau am Staffelsee, Germany (författare)
  • Gibbins, Jonathan M.Institute for Cardiovascular and Metabolic Research, School of Biological Sciences, Health and Life Sciences Building, University of Reading, RG6 6UR, UK (författare)
  • Limper, UlrichInstitute of Aerospace Medicine, German Aerospace Center (DLR), 51147 Cologne, Germany; Department of Anesthesiology and Intensive Care Medicine, Merheim Medical Center, Hospitals of Cologne, University of Witten/Herdecke, 51109 Cologne, Germany (författare)
  • Fröbert, Ole,1964-Örebro universitet,Institutionen för medicinska vetenskaper,Faculty of Health, Department of Cardiology, Örebro University, 701 85 Örebro, Sweden; Department of Clinical Medicine, Faculty of Health, Aarhus University, 8000 Aarhus, Denmark; Department of Clinical Pharmacology, Aarhus University Hospital, 8000 Aarhus, Denmark; Steno Diabetes Center Aarhus, Aarhus University Hospital, 8000 Aarhus, Denmark(Swepub:oru)oft (författare)
  • Mann, MatthiasDepartment of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany (författare)
  • Massberg, SteffenDepartment of Cardiology, University Hospital, LMU Munich, 81377 Munich, Germany; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, 80802 Munich, Germany (författare)
  • Petzold, TobiasDepartment of Cardiology, University Hospital, LMU Munich, 81377 Munich, Germany; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, 80802 Munich, Germany (författare)
  • Department of Cardiology, University Hospital, LMU Munich, 81377 Munich, Germany; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, 80802 Munich, GermanyDepartment of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany; Omicera Diagnostics, 82152 Martinsried, Germany (creator_code:org_t)
  • Sveriges lantbruksuniversitet

Sammanhörande titlar

  • Ingår i:Science: American Association for the Advancement of Science (AAAS)380:6641, s. 178-1870036-80751095-9203

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