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Immobility-associated thromboprotection is conserved across mammalian species from bear to human

Thienel, Manuela (författare)
Department of Cardiology, University Hospital, LMU Munich, 81377 Munich, Germany; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, 80802 Munich, Germany
Müller-Reif, Johannes B. (författare)
Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany; Omicera Diagnostics, 82152 Martinsried, Germany
Zhang, Zhe (författare)
Department of Cardiology, University Hospital, LMU Munich, 81377 Munich, Germany
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Ehreiser, Vincent (författare)
Department of Cardiology, University Hospital, LMU Munich, 81377 Munich, Germany; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, 80802 Munich, Germany
Huth, Judith (författare)
Department of Cardiology, University Hospital, LMU Munich, 81377 Munich, Germany; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, 80802 Munich, Germany
Shchurovska, Khrystyna (författare)
Department of Cardiology, University Hospital, LMU Munich, 81377 Munich, Germany; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, 80802 Munich, Germany
Kilani, Badr (författare)
Department of Cardiology, University Hospital, LMU Munich, 81377 Munich, Germany; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, 80802 Munich, Germany
Schweizer, Lisa (författare)
Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany
Geyer, Philipp E. (författare)
Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany; Omicera Diagnostics, 82152 Martinsried, Germany
Zwiebel, Maximilian (författare)
Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany
Novotny, Julia (författare)
Department of Cardiology, University Hospital, LMU Munich, 81377 Munich, Germany
Lüsebrink, Enzo (författare)
Department of Cardiology, University Hospital, LMU Munich, 81377 Munich, Germany
Little, Gemma (författare)
Institute for Cardiovascular and Metabolic Research, School of Biological Sciences, Health and Life Sciences Building, University of Reading, RG6 6UR, UK
Orban, Martin (författare)
Department of Cardiology, University Hospital, LMU Munich, 81377 Munich, Germany
Nicolai, Leo (författare)
Department of Cardiology, University Hospital, LMU Munich, 81377 Munich, Germany; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, 80802 Munich, Germany
El Nemr, Shaza (författare)
Department of Cardiology, University Hospital, LMU Munich, 81377 Munich, Germany; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, 80802 Munich, Germany
Titova, Anna (författare)
Department of Cardiology, University Hospital, LMU Munich, 81377 Munich, Germany; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, 80802 Munich, Germany
Spannagl, Michael (författare)
Anesthesiology and Transfusion Medicine, Cell Therapeutics and Hemostaseology, Ludwig-Maximilians-University Munich, 80336 Munich, Germany
Kindberg, Jonas (författare)
Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för vilt, fisk och miljö,Department of Wildlife, Fish and Environmental Studies,Norwegian Institute Nature Research
Evans, Alina L. (författare)
Department of Forestry and Wildlife Management, Faculty of Applied Ecology and Agricultural Sciences, Inland Norway University of Applied Sciences, 2480 Koppang, Norway
Mach, Orpheus (författare)
Zentrum für Rückenmarkverletzte mit Neuro-Urologie, BG Unfallklinik Murnau, 82418 Murnau am Staffelsee, Germany
Vogel, Matthias (författare)
Zentrum für Rückenmarkverletzte mit Neuro-Urologie, BG Unfallklinik Murnau, 82418 Murnau am Staffelsee, Germany
Tiedt, Steffen (författare)
Neurologische Klinik und Poliklinik, Klinikum der Universität München, Ludwig-Maximilians- University Munich, 81377 Munich, Germany
Ormanns, Steffen (författare)
Pathologisches Institut, Klinikum der Universität München, Ludwig-Maximilians- University Munich, 81377 Munich, Germany
Kessler, Barbara (författare)
Gene Center, Ludwig-Maximilians-University Munich, 81377 Munich, Germany
Dueck, Anne (författare)
DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, 80802 Munich, Germany; Institute of Pharmacology and Toxicology, Technical University of Munich, 80802 Munich, Germany
Friebe, Andrea (författare)
Norwegian Institute for Nature Research, 7034 Trondheim, Norway; Scandinavian Brown Bear Research Project, Tackåsen 2, SE-79498 Orsa, Sweden
Jørgensen, Peter Godsk (författare)
Herlev and Gentofte University Hospital, Borgmester Ib Juuls Vej 1, DK-2730, Herlev, Copenhagen, Denmark
Majzoub-Altweck, Monir (författare)
Institute of Veterinary Pathology, Center for Clinical Veterinary Medicine, LMU Munich, 80539 Munich, Germany
Blutke, Andreas (författare)
Institute of Veterinary Pathology, Center for Clinical Veterinary Medicine, LMU Munich, 80539 Munich, Germany
Polzin, Amin (författare)
Division of Cardiology, Pulmonology, and Vascular Medicine, Heinrich Heine University Medical Center Dusseldorf, 40225 Dusseldorf, Germany
Stark, Konstantin (författare)
Department of Cardiology, University Hospital, LMU Munich, 81377 Munich, Germany; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, 80802 Munich, Germany
Kääb, Stefan (författare)
Department of Cardiology, University Hospital, LMU Munich, 81377 Munich, Germany; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, 80802 Munich, Germany
Maier, Doris (författare)
Zentrum für Rückenmarkverletzte mit Neuro-Urologie, BG Unfallklinik Murnau, 82418 Murnau am Staffelsee, Germany
Gibbins, Jonathan M. (författare)
Institute for Cardiovascular and Metabolic Research, School of Biological Sciences, Health and Life Sciences Building, University of Reading, RG6 6UR, UK
Limper, Ulrich (författare)
Institute of Aerospace Medicine, German Aerospace Center (DLR), 51147 Cologne, Germany; Department of Anesthesiology and Intensive Care Medicine, Merheim Medical Center, Hospitals of Cologne, University of Witten/Herdecke, 51109 Cologne, Germany
Fröbert, Ole, 1964- (författare)
Örebro universitet,Institutionen för medicinska vetenskaper,Faculty of Health, Department of Cardiology, Örebro University, 701 85 Örebro, Sweden; Department of Clinical Medicine, Faculty of Health, Aarhus University, 8000 Aarhus, Denmark; Department of Clinical Pharmacology, Aarhus University Hospital, 8000 Aarhus, Denmark; Steno Diabetes Center Aarhus, Aarhus University Hospital, 8000 Aarhus, Denmark
Mann, Matthias (författare)
Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany
Massberg, Steffen (författare)
Department of Cardiology, University Hospital, LMU Munich, 81377 Munich, Germany; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, 80802 Munich, Germany
Petzold, Tobias (författare)
Department of Cardiology, University Hospital, LMU Munich, 81377 Munich, Germany; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, 80802 Munich, Germany
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 (creator_code:org_t)
 
American Association for the Advancement of Science (AAAS), 2023
2023
Engelska.
Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 380:6641, s. 178-187
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Venous thromboembolism (VTE) comprising deep venous thrombosis and pulmonary embolism is a major cause of morbidity and mortality. Short-term immobility-related conditions are a major risk factor for the development of VTE. Paradoxically, long-term immobilized free-ranging hibernating brown bears and paralyzed spinal cord injury (SCI) patients are protected from VTE. We aimed to identify mechanisms of immobility-associated VTE protection in a cross-species approach. Mass spectrometry-based proteomics revealed an antithrombotic signature in platelets of hibernating brown bears with heat shock protein 47 (HSP47) as the most substantially reduced protein. HSP47 down-regulation or ablation attenuated immune cell activation and neutrophil extracellular trap formation, contributing to thromboprotection in bears, SCI patients, and mice. This cross-species conserved platelet signature may give rise to antithrombotic therapeutics and prognostic markers beyond immobility-associated VTE.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kardiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
NATURVETENSKAP  -- Biologi -- Zoologi (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences -- Zoology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Immunology in the medical area (hsv//eng)

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