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(WFRF:(Kaltsas Gregory)) pers:(Weickert Martin O.)
 

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  • Tsoli, MarinaNeuroendocrine Tumour Unit, ENETS Centre of Excellence, First Department of Propaedeutic and Internal Medicine, Laiko Hospital, National and Kapodistrian University of Athens, Athens, Greece (author)

Pancreatic metastases in patients with neuroendocrine neoplasms : A multi-centre cohort study

  • Article/chapterEnglish2023

Publisher, publication year, extent ...

  • 2023-03-26
  • Blackwell Publishing,2023
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:oru-105763
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-105763URI
  • https://doi.org/10.1111/jne.13269DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Pancreatic metastases (PMs) from neuroendocrine neoplasms (NENs) are rare but the increased sensitivity of new diagnostic tools such as 68 Ga-DOTATATE PET/CT has resulted in their increased recognition at initial diagnosis or follow-up. A retrospective analysis of the data of patients from six tertiary referral centres was performed in order to identify the characteristics and the prognostic significance of PMs in patients with NENs. We used a control group of 69 age-, sex- and primary tumour - matched NEN patients from the same cohort with stage IV disease but no PMs. Overall survival (OS) was assessed using the Kaplan-Meier method log-rank analysis was used to assess the impact of various clinical and histopathological variables in OS. We identified 25 patients (11 females) with PMs with a median age at diagnosis of 60 years. The small intestine was the most common primary (80%) with a prevalence of 4.2% PMs (21/506). Fourteen patients presented with synchronous PMs whereas 11 developed metachronous PMs after a median time of 28 months (range: 7-168 months). Grading was available in 24 patients; 16 patients had G1 tumours, four G2, two atypical lung carcinoid, one typical and one atypical thymic carcinoid. Most patients had other concomitant metastases (12 hepatic, 4 lung and 6 bone) while five patients exhibited peritoneal carcinomatosis. Median OS in the PMs group was not reached compared with 212 months in the control group (95% CI: 26-398). The univariate analysis identified no prognostic factors statistically significantly associated with the OS. In conclusion, PMs are encountered with a low prevalence among NEN patients mostly developing in patients with advanced metastatic disease. The presence of PMs does not seem to be associated with a negative prognostic impact in OS.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Daskalakis, Kosmas,1979-Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Surgery, Faculty of Medicine and Health, Örebro University, Örebro, Sweden; Second Department of Surgery, "Korgialenio-Benakio", Red Cross General Hospital, Athens, Greece(Swepub:oru)kds (author)
  • Wedin, MariaDepartment of Surgery, Faculty of Medicine and Health, Örebro University, Örebro, Sweden (author)
  • Angelousi, AnnaUnit of Endocrinology, First Department of Internal Medicine, Laiko Hospital, National and Kapodistrian University of Athens, Athens, Greece (author)
  • Povlsen, SebastianNeuroendocrine Tumour Unit, ENETS Centre of Excellence, King's College Hospital, London, UK (author)
  • Srirajaskanthan, RajNeuroendocrine Tumour Unit, ENETS Centre of Excellence, King's College Hospital, London, UK (author)
  • Giovos, GeorgeThe ARDEN NET Centre, ENETS Centre of Excellence, University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK (author)
  • Weickert, Martin O.The ARDEN NET Centre, ENETS Centre of Excellence, University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK (author)
  • Kogut, AngelikaDepartment of Endocrinology and Neuroendocrine Tumours, Department of Pathophysiology and Endocrinology, Medical University of Silesia, Katowice, Poland (author)
  • Kos-Kudla, BeataDepartment of Endocrinology and Neuroendocrine Tumours, Department of Pathophysiology and Endocrinology, Medical University of Silesia, Katowice, Poland (author)
  • Oleinikov, KiraNeuroendocrine Unit, ENETS Centre of Excellence, Department of Endocrinology and Metabolism, Hadassah Medical Centre and Faculty of Medicine, The Hebrew University, Jerusalem, Israel (author)
  • Grozinsky-Glasberg, SimonaNeuroendocrine Unit, ENETS Centre of Excellence, Department of Endocrinology and Metabolism, Hadassah Medical Centre and Faculty of Medicine, The Hebrew University, Jerusalem, Israel (author)
  • Kaltsas, GregoryNeuroendocrine Tumour Unit, ENETS Centre of Excellence, First Department of Propaedeutic and Internal Medicine, Laiko Hospital, National and Kapodistrian University of Athens, Athens, Greece (author)
  • Neuroendocrine Tumour Unit, ENETS Centre of Excellence, First Department of Propaedeutic and Internal Medicine, Laiko Hospital, National and Kapodistrian University of Athens, Athens, GreeceInstitutionen för medicinska vetenskaper (creator_code:org_t)

Related titles

  • In:Journal of neuroendocrinology: Blackwell Publishing35:40953-81941365-2826

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