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ARG1-expressing mic...
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Stratoulias, VassilisInstitute of Environmental Medicine, Toxicology Unit, Karolinska Institutet, Stockholm, Sweden; Neuroscience Center, HiLIFE, University of Helsinki, Helsinki, Finland
(författare)
ARG1-expressing microglia show a distinct molecular signature and modulate postnatal development and function of the mouse brain
- Artikel/kapitelEngelska2023
Förlag, utgivningsår, omfång ...
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Nature Publishing Group,2023
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:oru-105921
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-105921URI
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https://doi.org/10.1038/s41593-023-01326-3DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-209132URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:152585610URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Funding agencies:Strategic Research Area in Neuroscience (StratNeuro)Strategic Research Area in Stemc Cells and Regenerative Medicine (StratRegen) - Swedish governmentSigrid Juselius FoundationSvenska KulturfondenSwedish Cancer SocietyConsejo Nacional de Ciencia y Tecnologia (CONACyT)Fonds de la Recherche en Sante du QuebecSpanish Ministerio de Ciencia e Innovacion/FEDER/UE PID2021-124096OB-I00 PID 2019-109569GB-100 BFU2015-68655Spanish Junta de Andalucia/FEDER/EU P18-RT-1372Spanish FEDER I+D+i-USE US-1264806Swedish governmental grants for researchers working in healthcareCanada Research Chair (Tier 2) in Neurobiology of Aging and CognitionTracInflam grant from ERA-NET NEURON Neuroinflammation
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Molecular diversity of microglia, the resident immune cells in the CNS, is reported. Whether microglial subsets characterized by the expression of specific proteins constitute subtypes with distinct functions has not been fully elucidated. Here we describe a microglial subtype expressing the enzyme arginase-1 (ARG1; that is, ARG1+ microglia) that is found predominantly in the basal forebrain and ventral striatum during early postnatal mouse development. ARG1+ microglia are enriched in phagocytic inclusions and exhibit a distinct molecular signature, including upregulation of genes such as Apoe, Clec7a, Igf1, Lgals3 and Mgl2, compared to ARG1- microglia. Microglial-specific knockdown of Arg1 results in deficient cholinergic innervation and impaired dendritic spine maturation in the hippocampus where cholinergic neurons project, which in turn results in impaired long-term potentiation and cognitive behavioral deficiencies in female mice. Our results expand on microglia diversity and provide insights into microglia subtype-specific functions.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Ruiz, RocíoInstituto de Biomedicina de Sevilla, IBiS/Hospital Universitario Virgen del Rocío/CSIC, Universidad de Sevilla, Seville, Spain
(författare)
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Kanatani, ShigeakiKarolinska Institutet
(författare)
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Osman, Ahmed M.Karolinska Institutet
(författare)
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Keane, LilyInstitute of Environmental Medicine, Toxicology Unit, Karolinska Institutet, Stockholm, Sweden
(författare)
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Armengol, Jose A.Department of Physiology, Anatomy and Cellular Biology, University of Pablo de Olavide, Seville, Spain
(författare)
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Rodríguez-Moreno, AntonioDepartment of Physiology, Anatomy and Cellular Biology, University of Pablo de Olavide, Seville, Spain
(författare)
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Murgoci, Adriana-NataliaKarolinska Institutet
(författare)
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García-Domínguez, IreneInstituto de Biomedicina de Sevilla, IBiS/Hospital Universitario Virgen del Rocío/CSIC, Universidad de Sevilla, Seville, Spain
(författare)
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Alonso-Bellido, IsabelInstituto de Biomedicina de Sevilla, IBiS/Hospital Universitario Virgen del Rocío/CSIC, Universidad de Sevilla, Seville, Spain
(författare)
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González Ibáñez, FernandoDepartment of Molecular Medicine, Université Laval, and Axe Neurosciences, Centre de Recherche du CHU de Québec-Université Laval, Laval, Quebec, Canada; Division of Medical Sciences, University of Victoria, Victoria, British Columbia, Canada
(författare)
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Picard, KatherineDepartment of Molecular Medicine, Université Laval, and Axe Neurosciences, Centre de Recherche du CHU de Québec-Université Laval, Laval, Quebec, Canada; Division of Medical Sciences, University of Victoria, Victoria, British Columbia, Canada
(författare)
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Vázquez-Cabrera, GuillermoKarolinska Institutet
(författare)
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Posada-Pérez, MercedesInstitute of Environmental Medicine, Toxicology Unit, Karolinska Institutet, Stockholm, Sweden; Instituto de Biomedicina de Sevilla, IBiS/Hospital Universitario Virgen del Rocío/CSIC, Universidad de Sevilla, Seville, Spain
(författare)
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Vernoux, NathalieDepartment of Molecular Medicine, Université Laval, and Axe Neurosciences, Centre de Recherche du CHU de Québec-Université Laval, Laval, Quebec, Canada
(författare)
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Tejera, DarioDepartment of Neurodegenerative Diseases and Gerontopsychiatry, University of Bonn, Bonn, Germany
(författare)
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Grabert, KathleenKarolinska Institutet
(författare)
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Cheray, MathildeKarolinska Institutet
(författare)
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González-Rodríguez, PatriciaInstitute of Environmental Medicine, Toxicology Unit, Karolinska Institutet, Stockholm, Sweden
(författare)
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Pérez-Villegas, Eva M.Department of Physiology, Anatomy and Cellular Biology, University of Pablo de Olavide, Seville, Spain
(författare)
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Martínez-Gallego, IreneDepartment of Physiology, Anatomy and Cellular Biology, University of Pablo de Olavide, Seville, Spain
(författare)
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Lastra-Romero, AlejandroDepartment of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden
(författare)
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Brodin, DavidKarolinska Institutet
(författare)
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Avila-Cariño, Javier,1957-Umeå universitet,Umeå Centre for Microbial Research (UCMR),Institutionen för molekylärbiologi (Medicinska fakulteten),Institutionen för molekylärbiologi (Teknisk-naturvetenskaplig fakultet)(Swepub:umu)jaav0002
(författare)
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Cao, Yang,Associate Professor,1972-Karolinska Institutet,Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Clinical Epidemiology and Biostatistics, School of Medical Sciences, Örebro University, Örebro, Sweden; Unit of Integrative Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden(Swepub:oru)yco
(författare)
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Airavaara, MikkoNeuroscience Center, HiLIFE, University of Helsinki, Helsinki, Finland; Faculty of Pharmacy, Drug Research Program, University of Helsinki, Helsinki, Finland
(författare)
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Uhlén, PerDepartment of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
(författare)
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Heneka, Michael T.Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Belvaux, Luxembourg; Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, MA, Worcester, United States
(författare)
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Tremblay, Marie-ÈveDepartment of Molecular Medicine, Université Laval, and Axe Neurosciences, Centre de Recherche du CHU de Québec-Université Laval, Laval, Quebec, Canada; Division of Medical Sciences, University of Victoria, Victoria, British Columbia, Canada
(författare)
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Blomgren, KlasKarolinska Institutet
(författare)
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Venero, Jose L.Instituto de Biomedicina de Sevilla, IBiS/Hospital Universitario Virgen del Rocío/CSIC, Universidad de Sevilla, Seville, Spain
(författare)
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Joseph, BertrandKarolinska Institutet
(författare)
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Institute of Environmental Medicine, Toxicology Unit, Karolinska Institutet, Stockholm, Sweden; Neuroscience Center, HiLIFE, University of Helsinki, Helsinki, FinlandInstituto de Biomedicina de Sevilla, IBiS/Hospital Universitario Virgen del Rocío/CSIC, Universidad de Sevilla, Seville, Spain
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Nature Neuroscience: Nature Publishing Group26:6, s. 1008-10201097-62561546-1726
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Stratoulias, Vas ...
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Ruiz, Rocío
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Kanatani, Shigea ...
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Osman, Ahmed M.
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Keane, Lily
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Armengol, Jose A ...
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Rodríguez-Moreno ...
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Murgoci, Adriana ...
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García-Domínguez ...
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Alonso-Bellido, ...
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González Ibáñez, ...
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Picard, Katherin ...
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Vázquez-Cabrera, ...
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Posada-Pérez, Me ...
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Vernoux, Nathali ...
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Tejera, Dario
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Grabert, Kathlee ...
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Cheray, Mathilde
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González-Rodrígu ...
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Pérez-Villegas, ...
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Martínez-Gallego ...
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Lastra-Romero, A ...
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Brodin, David
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Avila-Cariño, Ja ...
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Cao, Yang, Assoc ...
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Airavaara, Mikko
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Uhlén, Per
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Heneka, Michael ...
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Tremblay, Marie- ...
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Blomgren, Klas
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Venero, Jose L.
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Joseph, Bertrand
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