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Potential Modulatio...
Potential Modulation of Inflammation and Physical Function by Combined Probiotics, Omega-3 Supplementation and Vitamin D Supplementation in Overweight/Obese Patients with Chronic Low-Grade Inflammation : A Randomized, Placebo-Controlled Trial
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- Kopp, Lena (författare)
- Department of Nutritional Medicine and Prevention, University of Hohenheim, Stuttgart, Germany,Univ Hohenheim, Germany
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- Schweinlin, Anna (författare)
- Department of Nutritional Medicine and Prevention, University of Hohenheim, Stuttgart, Germany,Univ Hohenheim, Germany
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- Tingö, Lina, 1984- (författare)
- Linköpings universitet,Örebro universitet,Institutionen för medicinska vetenskaper,Nutrition-Gut-Brain Interactions Research Centre, School of Medical Sciences, Örebro University, Örebro, Sweden; Food and Health Programme, Örebro University, Örebro, Sweden, Division of Inflammation and Infection, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden,Avdelningen för inflammation och infektion,Medicinska fakulteten,Orebro Univ, Sweden
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- Hutchinson, Ashley N., 1984, 1984- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Nutrition-Gut-Brain Interactions Research Centre,Orebro Univ, Sweden
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- Feit, Viktoria (författare)
- Department of Nutritional Medicine and Prevention, University of Hohenheim, Stuttgart, Germany,Univ Hohenheim, Germany
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- Jähnichen, Tabea (författare)
- Department of Nutritional Medicine and Prevention, University of Hohenheim, Stuttgart, Germany,Univ Hohenheim, Germany
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- Lehnert, Katja (författare)
- Institute of Food Chemistry (170b), University of Hohenheim, Stuttgart, Germany,Univ Hohenheim, Germany
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- Vetter, Walter (författare)
- Institute of Food Chemistry (170b), University of Hohenheim, Stuttgart, Germany,Univ Hohenheim, Germany
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- Rings, Andreas (författare)
- Department of Nutritional Medicine and Prevention, University of Hohenheim, Stuttgart, Germany,Univ Hohenheim, Germany
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- Jensen, Morten G. (författare)
- Haleon, Vallensbæk Strand, Denmark
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- Brummer, Robert J., 1957- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Nutrition-Gut-Brain Interactions Research Centre,Orebro Univ, Sweden
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- Bischoff, Stephan C. (författare)
- Department of Nutritional Medicine and Prevention, University of Hohenheim, Stuttgart, Germany,Univ Hohenheim, Germany
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(creator_code:org_t)
- MDPI, 2023
- 2023
- Engelska.
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Ingår i: International Journal of Molecular Sciences. - : MDPI. - 1661-6596 .- 1422-0067. ; 24:10
- Relaterad länk:
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https://doi.org/10.3...
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https://liu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.3...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Obesity is characterized by low-grade inflammation and increased gut permeability. Here, we aim to evaluate the effect of a nutritional supplement on these parameters in subjects with overweight and obesity. A double-blinded, randomized clinical trial was conducted in 76 adults with overweight or obesity (BMI 28 to 40) and low-grade inflammation (high-sensitivity C-reactive protein (hs-CRP) between 2 and 10 mg/L). The intervention consisted of a daily intake of a multi-strain probiotic of Lactobacillus and Bifidobacterium, 640 mg of omega-3 fatty acids (n-3 FAs), and 200 IU of vitamin D (n = 37) or placebo (n = 39), administered for 8 weeks. hs-CRP levels did not change post-intervention, other than an unexpected slight increase observed in the treatment group. Interleukin (IL)-6 levels decreased in the treatment group (p = 0.018). The plasma fatty acid (FA) levels of the arachidonic acid (AA)/eicosapentaenoic acid (EPA) ratio and n-6/n-3 ratio (p < 0.001) decreased, and physical function and mobility improved in the treatment group (p = 0.006). The results suggest that hs-CRP may not be the most useful inflammatory marker, but probiotics, n-3 FAs, and vitamin D, as non-pharmaceutical supplements, may exert modest effects on inflammation, plasma FA levels, and physical function in patients with overweight and obesity and associated low-grade inflammation.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Odontologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dentistry (hsv//eng)
Nyckelord
- obesity
- overweight
- chronic low-grade inflammation
- probiotics
- omega-3 fatty acids
- hs-CRP
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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Kopp, Lena
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Schweinlin, Anna
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Tingö, Lina, 198 ...
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Hutchinson, Ashl ...
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Feit, Viktoria
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Jähnichen, Tabea
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visa fler...
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Lehnert, Katja
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Vetter, Walter
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Rings, Andreas
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Jensen, Morten G ...
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Brummer, Robert ...
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Bischoff, Stepha ...
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Örebro universitet
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Linköpings universitet