Epidemiological overview of major depressive disorder in Scandinavia using nationwide registers

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Epidemiological overview of major depressive disorder in Scandinavia using nationwide registers

Pasman, Joëlle A. (författare): Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Sweden

Meijsen, Joeri J. (författare): Institute of Biological Psychiatry, Mental Health Center Sct. Hans, Mental Health Services Copenhagen, Roskilde, Denmark; The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Copenhagen, Denmark

Haram, Marit (författare): Department of Mental Disorders, Norwegian Institute of Public Health, Oslo, Norway; Division of Mental Health and Addiction, Oslo University Hospital, Norway

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Kowalec, Kaarina (författare): Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Sweden; College of Pharmacy, University of Manitoba, Canada

Harder, Arvid (författare): Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Sweden

Xiong, Ying (författare): Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Sweden

Nguyen, Thuy-Dung (författare): Karolinska Institutet

Jangmo, Andreas (författare): Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Sweden; Department of Mental Disorders, Norwegian Institute of Public Health, Oslo, Norway

Shorter, John R. (författare): Institute of Biological Psychiatry, Mental Health Center Sct. Hans, Mental Health Services Copenhagen, Roskilde, Denmark; The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Copenhagen, Denmark; Department of Science and Environment, Roskilde University, Denmark

Bergstedt, Jacob (författare): Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Sweden; Unit of Integrative Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden

Das, Urmi (författare): College of Pharmacy, University of Manitoba, Canada

Zetterberg, Richard (författare): Institute of Biological Psychiatry, Mental Health Center Sct. Hans, Mental Health Services Copenhagen, Roskilde, Denmark; The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Copenhagen, Denmark

Tate, Ashley (författare): Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Sweden

Lichtenstein, Paul (författare): Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Sweden

Larsson, Henrik, 1975- (författare): Örebro universitet,Institutionen för medicinska vetenskaper,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Sweden

Odsbu, Ingvild (författare): The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Copenhagen, Denmark

Werge, Thomas (författare): Institute of Biological Psychiatry, Mental Health Center Sct. Hans, Mental Health Services Copenhagen, Roskilde, Denmark; The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Copenhagen, Denmark; Lundbeck Foundation GeoGenetics Centre, GLOBE Institute, University of Copenhagen, Copenhagen, Denmark

Reichborn-Kjennerud, Ted (författare): Department of Mental Disorders, Norwegian Institute of Public Health, Oslo, Norway

Andreassen, Ole A. (författare): Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; NORMENT Centre, Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, Norway

Sullivan, Patrick F. (författare): Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Sweden; K.G. Jebsen Centre for Neurodevelopmental Disorders, University of Oslo and Oslo University Hospital, Oslo, Norway

Buil, Alfonso (författare): Institute of Biological Psychiatry, Mental Health Center Sct. Hans, Mental Health Services Copenhagen, Roskilde, Denmark; The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Copenhagen, Denmark

Tesli, Martin (författare): Department of Mental Disorders, Norwegian Institute of Public Health, Oslo, Norway; Departments of Genetics and Psychiatry, University of North Carolina at Chapel Hill, NC, USA; Centre of Research and Education in Forensic Psychiatry, Oslo University Hospital, Oslo, Norway

Lu, Yi (författare): Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Sweden

Lua, Y (författare)

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Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Sweden Institute of Biological Psychiatry, Mental Health Center Sct Hans, Mental Health Services Copenhagen, Roskilde, Denmark; The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Copenhagen, Denmark (creator_code:org_t)

Elsevier, 2023
2023
Engelska.
Ingår i: The Lancet Regional Health. - : Elsevier. - 2666-7762. ; 29

Relaterad länk:: https://doi.org/10.1...; visa fler...; https://urn.kb.se/re...; https://doi.org/10.1...; http://kipublication...; visa färre...

Tidskriftsartikel (refereegranskat)

Abstract Ämnesord

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BACKGROUND: Major depressive disorder (MDD) is a common psychiatric disorder associated with a high disease burden. This study gives a comprehensive overview of the prevalence, outcomes, treatment, and genetic epidemiology of MDD within and across the Scandinavian countries.METHODS: This study has aimed to assess and compare across Norway, Denmark, and Sweden 1) the prevalence and trajectories of MDD and comorbidity, 2) outcomes and treatment, and 3) heritability (Denmark and Sweden only). The analyses leveraged data on 272,944 MDD cases (and 6.2 million non-cases) from Norway, Sweden, and Denmark in specialist care in national longitudinal health registers covering 1975-2013. Relying on harmonized public data global comparisons of socioeconomic and health metrics were performed to assess to what extent findings are generalizable.FINDINGS: MDD ranked among the most prevalent psychiatric disorders. For many cases, the disorder trajectory was severe, with varying proportions experiencing recurrence, developing comorbid disorders, requiring inpatient treatment, or dying of suicide. Important country differences in specialist care prevalence and treatment were observed. Heritability estimates were moderate (35-48%). In terms of socioeconomic and health indices, the Scandinavian nations were comparable to one another and grouped with other Western nations.INTERPRETATION: The Scandinavian countries were similar with regards to MDD epidemiological measures, but we show that differences in health care organization need to be taken into consideration when comparing countries. This study demonstrates the utility of using comprehensive population-wide registry data, outlining possibilities for other applications. The findings will be of use to policy makers for developing better prevention and intervention strategies.

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Psykiatri

Artiklar i publikationen: The Lancet Regio ...

Av lärosätet: Örebro universitet; Karolinska Institutet

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Epidemiological overview of major depressive disorder in Scandinavia using nationwide registers

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