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  • Visuri, Isabella,1991-Örebro universitet,Institutionen för medicinska vetenskaper,Department of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden,Orebro Univ, Sweden (författare)

Long-term outcomes of vedolizumab in inflammatory bowel disease : the Swedish prospective multicentre SVEAH extension study

  • Artikel/kapitelEngelska2023

Förlag, utgivningsår, omfång ...

  • Sage Publications,2023
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:oru-106367
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-106367URI
  • https://doi.org/10.1177/17562848231174953DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:153282379URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-196910URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding agencies:Takeda Pharmaceutical Company Ltd EUPAS22735Swedish government's agreement on medical training and research OLL-836791 OLL-934569 OLL-929900 OLL-960775 
  • Funding Agencies|Takeda [EUPAS22735]; Swedish governments agreement on medical training and research [OLL-836791, OLL-934569, OLL-929900, OLL-960775]
  • BACKGROUND: Real-world data on long-term outcomes of vedolizumab (VDZ) are scarce.OBJECTIVE: To assess long-term outcomes (up to 3 years) of VDZ in treating inflammatory bowel disease (IBD).DESIGN: A nationwide, prospective multicentre extension of a Swedish observational study on VDZ assessing Effectiveness And Healthcare resource utilization in patients with IBD (SVEAH).METHODS: After re-consent, data of patients with Crohn's disease (CD) (n = 68) and ulcerative colitis (UC) (n = 46) treated with VDZ were prospectively recorded using an electronic case report form integrated with the Swedish IBD Register (SWIBREG). The primary outcome was clinical remission (defined as Harvey-Bradshaw Index ⩽4 in CD and partial Mayo score ⩽2 in UC) at 104 and 156 weeks in patients with a response and/or remission 12 weeks after starting VDZ. Secondary outcomes included health-related quality of life (HRQoL) and biochemical outcomes.RESULTS: VDZ continuation rates were high at weeks 104 and 156, 88% and 84%, respectively, for CD and 87% and 78%, respectively, for UC. Of the 53 CD patients with a response/remission at 12 weeks, 40 (75%) patients were in remission at 104 weeks and 42 (79%) patients at 156 weeks. For UC, these numbers were 25/31 (81%) and 22/31 (71%), respectively. Improvements were seen in the Short Health Scale (p < 0.01 for each dimension; CD, n = 51; UC, n = 33) and the EuroQol 5-Dimensions, 5-levels index value (p < 0.01; CD, n = 39; UC, n = 30). Median plasma-C-reactive protein concentrations (mg/L) decreased from 5 at baseline to 4 in CD (p = 0.01, n = 53) and from 5 to 4 in UC (p = 0.03, n = 34) at 156 weeks. Correspondingly, median faecal-calprotectin (µg/g) decreased from 641 to 114 in CD patients (p < 0.01, n = 26) and from 387 to 37 in UC patients (p = 0.02, n = 17).CONCLUSION: VDZ demonstrated high continuation rates and was associated with improvements in clinical outcomes, HRQoL measures and inflammatory markers at 2 and 3 years after treatment initiation in this prospective national SVEAH extension study.REGISTRATION: ENCePP registration number: EUPAS22735.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Eriksson, Carl,1981-Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden; Clinical Epidemiology Division, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden,Orebro Univ, Sweden; Karolinska Inst, Sweden(Swepub:oru)clen (författare)
  • Karlqvist, Sara,1992-Örebro universitet,Institutionen för medicinska vetenskaper,Department of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden,Orebro Univ, Sweden(Swepub:oru)srt (författare)
  • Lykiardopoulos, ByronLinköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Mag- tarmmedicinska kliniken(Swepub:liu)byrly66 (författare)
  • Karlén, PerDepartment of Internal Medicine, Danderyd Hospital, Stockholm, Sweden,Danderyd Hosp, Sweden (författare)
  • Grip, OlofDepartment of Gastroenterology, Skåne University Hospital, Malmö/Lund, Sweden,Skane Univ Hosp, Sweden (författare)
  • Söderman, CharlotteKarolinska Institutet,St Goran Hosp, Sweden (författare)
  • Almer, SvenKarolinska Institutet,Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden (författare)
  • Hertervig, ErikDepartment of Gastroenterology, Skåne University Hospital, Malmö/Lund, Sweden,Skane Univ Hosp, Sweden (författare)
  • Marsal, JanDepartment of Gastroenterology, Skåne University Hospital, Malmö/Lund, Sweden,Skane Univ Hosp, Sweden (författare)
  • Malmgren, CarolinaTakeda Pharma AB, Stockholm, Sweden (författare)
  • Delin, JennyDepartment of Gastroenterology, Ersta Hospital, Stockholm, Sweden,Ersta Hosp, Sweden (författare)
  • Strid, HansDepartment of Internal Medicine, Södra Älvsborgs Hospital, Borås, Sweden,Sodra Alvsborgs Hosp, Sweden (författare)
  • Sjöberg, MatsDepartment of Internal Medicine, Skaraborgs Hospital, Lidköping, Sweden,Skaraborgs Hosp, Sweden (författare)
  • Bergemalm, DanielDepartment of Gastroenterology,Orebro Univ, Sweden (författare)
  • Hjortswang, HenrikLinköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Mag- tarmmedicinska kliniken(Swepub:liu)henhj44 (författare)
  • Halfvarson, Jonas,1970-Örebro universitet,Institutionen för medicinska vetenskaper,Department of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden,Orebro Univ, Sweden(Swepub:oru)jshn (författare)
  • Örebro universitetInstitutionen för medicinska vetenskaper (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Therapeutic Advances in Gastroenterology: Sage Publications161756-283X1756-2848

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