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Formerly bile-farme...
Formerly bile-farmed bears as a model of accelerated ageing
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- Kalogeropoulu, Szilvia K. (författare)
- Department of Interdisciplinary Life Sciences, Research Institute of Wildlife Ecology, University of Veterinary Medicine, 1160, Vienna, Austria
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- Rauch-Schmücking, Hanna (författare)
- Department of Interdisciplinary Life Sciences, Research Institute of Wildlife Ecology, University of Veterinary Medicine, 1160, Vienna, Austria
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- Lloyd, Emily J. (författare)
- BEAR SANCTUARY Ninh Binh, FOUR PAWS Viet, Ninh Binh, 43000, Vietnam
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- Stenvinkel, Peter (författare)
- Karolinska Institutet
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- Shiels, Paul G. (författare)
- Davidson Bld, School of Molecular Biosciences, University of Glasgow, Glasgow, GB, UK
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- Johnson, Richard J. (författare)
- Division of Renal Diseases, University of Colorado Anschutz Medical Campus, Aurora, CO, USA
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- Fröbert, Ole, 1964- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Cardiology, Faculty of Health, Örebro University, Örebro, Sweden; Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark; Department of Clinical Medicine, Faculty of Health, Aarhus University, Aarhus, Denmark; Department of Clinical Pharmacology, Aarhus University Hospital, Aarhus, Denmark
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- Redtenbacher, Irene (författare)
- Four Paws International, Vienna, Austria
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- Burgener, Iwan A. (författare)
- Division of Small Animal Internal Medicine, Department for Companion Animals and Horses, University of Veterinary Medicine, 1210, Vienna, Austria
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- Painer-Gigler, Johanna (författare)
- Department of Interdisciplinary Life Sciences, Research Institute of Wildlife Ecology, University of Veterinary Medicine, 1160, Vienna, Austria
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(creator_code:org_t)
- Nature Publishing Group, 2023
- 2023
- Engelska.
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Ingår i: Scientific Reports. - : Nature Publishing Group. - 2045-2322. ; 13:1
- Relaterad länk:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Bear bile-farming is common in East and Southeast Asia and this farming practice often results in irreversible health outcomes for the animals. We studied long-term effects of chronic bacterial and sterile hepatobiliary inflammation in 42 Asiatic black bears (Ursus thibetanus) rescued from Vietnamese bile farms. The bears were examined under anesthesia at least twice as part of essential medical interventions. All bears were diagnosed with chronic low-grade sterile or bacterial hepatobiliary inflammation along with pathologies from other systems. Our main finding was that the chronic low-grade inflammatory environment associated with bile extraction in conjunction with the suboptimal living conditions on the farms promoted and accelerated the development of age-related pathologies such as chronic kidney disease, obese sarcopenia, cardiovascular remodeling, and degenerative joint disease. Through a biomimetic approach, we identified similarities with inflammation related to premature aging in humans and found significant deviations from the healthy ursid phenotype. The pathological parallels with inflammageing and immuno-senescence induced conditions in humans suggest that bile-farmed bears may serve as animal models to investigate pathophysiology and deleterious effects of lifestyle-related diseases.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
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Kalogeropoulu, S ...
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Rauch-Schmücking ...
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Lloyd, Emily J.
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Stenvinkel, Pete ...
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Shiels, Paul G.
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Johnson, Richard ...
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visa fler...
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Fröbert, Ole, 19 ...
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Redtenbacher, Ir ...
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Burgener, Iwan A ...
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Painer-Gigler, J ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Reumatologi och ...
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Scientific Repor ...
- Av lärosätet
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Örebro universitet
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Karolinska Institutet