Mortality in small bowel cancers and adenomas: A nationwide, population-based matched cohort study

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Emilsson, Louise,1982-Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of General Practice, Institute of Health and Society, University of Oslo, Oslo, Norway; Vårdcentralen Värmlands Nysäter and Centre for Clinical Research, County Council of Värmland, Sweden; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Solna, Sweden (författare)

Mortality in small bowel cancers and adenomas : A nationwide, population-based matched cohort study

Artikel/kapitelEngelska2023

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Elsevier,2023
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LIBRIS-ID:oai:DiVA.org:oru-107216
https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-107216URI
https://doi.org/10.1016/j.canep.2023.102399DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:153192286URI

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Språk:engelska
Sammanfattning på:engelska

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Funding agencies:Janssen corporationMSD developing a paper reviewing national healthcare registers in China
Background: Small bowel adenocarcinoma (SBA), neuroendocrine tumors (NET) and gastrointestinal stromal tumors (GIST) are neoplastic lesions of the small bowel while small bowel adenomas are precursors of SBA.Aim: To examine mortality in patients diagnosed with SBA, small bowel adenomas, NET and GIST.Methods: We performed a population-based matched cohort study encompassing all individuals with SBA (n = 2289), adenomas (n = 3700), NET (n = 1884) and GIST (n = 509) in the small bowel diagnosed at any of Sweden's 28 pathology departments between 2000 and 2016 (the "ESPRESSO study"). Each case was matched by sex, age, calendar year and county of residence to up to 5 comparators from the general population. Through Cox regression we estimated hazard ratios (HRs) and 95% confidence intervals (95%CIs) for death and cause-specific death adjusting for education.Results: During follow-up until December 31, 2017, 1836 (80%) deaths occurred in SBA patients, 1615 (44%) in adenoma, 866 (46%) in NET and 162 (32%) in GIST patients. This corresponded to incidence rates of 295, 74, 80 and 62/1000 person-years respectively and adjusted HRs of 7.60 (95%CI=6.95-8.31), 2.21 (2.07-2.36), 2.74 (2.50-3.01) and 2.33 (1.90-2.87). Adjustment for education had a substantial impact on the HR for death in SBA but not for other neoplasias. The predominant cause of excess death was cancer in all groups.Conclusion: This study confirms earlier findings of increased death rates in patients with SBA and NET in a modern study population. We also demonstrate a more than 2-fold increased risk of death in both GIST and the SBA precursor adenoma.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Cancer och onkologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology hsv//eng
Prognosis
Small bowel neoplasia
Small bowel adenomas
Cohort study

Biuppslag (personer, institutioner, konferenser, titlar ...)

Maret-Ouda, JohnDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Solna, Sweden (författare)
Ludvigsson, Jonas F.,1969-Karolinska Institutet,Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Solna, Sweden; Department of Pediatrics, Örebro University Hospital, Sweden; Celiac Disease Center, Department of Medicine, Columbia University College of Physicians and Surgeons, New York NY, USA(Swepub:oru)jsln (författare)
Örebro universitetInstitutionen för medicinska vetenskaper (creator_code:org_t)

Sammanhörande titlar

Ingår i:Cancer Epidemiology: Elsevier851877-78211877-783X

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Av författaren/redakt...: Emilsson, Louise ...; Maret-Ouda, John; Ludvigsson, Jona ...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Cancer och onkol ...

Artiklar i publikationen: Cancer Epidemiol ...

Av lärosätet: Örebro universitet; Karolinska Institutet

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